Cheap flights To Serena (VYS) from $51

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Cheap Flights to Serena from $51 One Way, $100 Round Trip

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Thu, Dec 4 - Sun, Dec 7
BWI
Baltimore Washington Intl. Thurgood Marshall
MDW
Midway Intl.
$100 Roundtrip, found 1 day ago
$100
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Dec 4 from Baltimore Washington Intl. Thurgood Marshall to Midway Intl., returning Sun, Dec 7, priced at $100 found 1 day ago
Thu, Dec 4 - Thu, Dec 11
BWI
Baltimore Washington Intl. Thurgood Marshall
ORD
O'Hare Intl.
$100 Roundtrip, just found
$100
Roundtrip
just found
Select Spirit Airlines flight, departing Thu, Dec 4 from Baltimore Washington Intl. Thurgood Marshall to O'Hare Intl., returning Thu, Dec 11, priced at $100 just found
Fri, Nov 14 - Mon, Nov 17
BWI
Baltimore Washington Intl. Thurgood Marshall
MDW
Midway Intl.
$102 Roundtrip, found 16 hours ago
$102
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Fri, Nov 14 from Baltimore Washington Intl. Thurgood Marshall to Midway Intl., returning Mon, Nov 17, priced at $102 found 16 hours ago
Thu, Oct 30 - Mon, Nov 10
BWI
Baltimore Washington Intl. Thurgood Marshall
ORD
O'Hare Intl.
$103 Roundtrip, found 1 day ago
$103
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 30 from Baltimore Washington Intl. Thurgood Marshall to O'Hare Intl., returning Mon, Nov 10, priced at $103 found 1 day ago
Sat, Oct 25 - Fri, Oct 31
BWI
Baltimore Washington Intl. Thurgood Marshall
MDW
Midway Intl.
$105 Roundtrip, found 1 day ago
$105
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Oct 25 from Baltimore Washington Intl. Thurgood Marshall to Midway Intl., returning Fri, Oct 31, priced at $105 found 1 day ago
Sat, Oct 25 - Mon, Oct 27
BWI
Baltimore Washington Intl. Thurgood Marshall
MDW
Midway Intl.
$105 Roundtrip, found 17 hours ago
$105
Roundtrip
found 17 hours ago
Select Frontier Airlines flight, departing Sat, Oct 25 from Baltimore Washington Intl. Thurgood Marshall to Midway Intl., returning Mon, Oct 27, priced at $105 found 17 hours ago
Wed, Oct 15 - Sat, Oct 25
LAX
Los Angeles Intl.
ORD
O'Hare Intl.
$106 Roundtrip, found 1 day ago
$106
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, Oct 15 from Los Angeles Intl. to O'Hare Intl., returning Sat, Oct 25, priced at $106 found 1 day ago
Sat, Feb 7 - Sat, Feb 7
BWI
Baltimore Washington Intl. Thurgood Marshall
ORD
O'Hare Intl.
$134 Roundtrip, found 22 hours ago
$134
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Feb 7 from Baltimore Washington Intl. Thurgood Marshall to O'Hare Intl., returning Sat, Feb 7, priced at $134 found 22 hours ago
Sat, Nov 1 - Tue, Nov 4
BWI
Baltimore Washington Intl. Thurgood Marshall
MDW
Midway Intl.
$139 Roundtrip, found 4 days ago
$139
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Sat, Nov 1 from Baltimore Washington Intl. Thurgood Marshall to Midway Intl., returning Tue, Nov 4, priced at $139 found 4 days ago
Sat, Nov 1 - Sun, Nov 9
BWI
Baltimore Washington Intl. Thurgood Marshall
ORD
O'Hare Intl.
$161 Roundtrip, found 1 hour ago
$161
Roundtrip
found 1 hour ago
Select United flight, departing Sat, Nov 1 from Baltimore Washington Intl. Thurgood Marshall to O'Hare Intl., returning Sun, Nov 9, priced at $161 found 1 hour ago

Serena Flight Information

Traveling To
Serena
Destination Airport IATA Code
VYS
Number of Airlines Serving
Airlines
Spirit Airlines, Frontier Airlines, Southwest Airlines, American Airlines, United
Flight Price
$100
Earliest Departing Flight
Latest Departing Flight

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Serena economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Allegro Royal Sonesta Hotel Chicago Loop
4.0-star property

The Allegro Royal Sonesta Hotel Chicago Loop

Oct 31 - Nov 5

5 night stay

Atlanta (ATL) to Chicago (ORD)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $902, price is now $504 per person
$504
per person
found 1 day ago
Level Chicago - River North
4.0-star property

Level Chicago - River North

Oct 31 - Nov 5

5 night stay

Atlanta (ATL) to Chicago (ORD)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $1,215, price is now $676 per person
$676
per person
found 1 day ago
Level Chicago Fulton Market
4.0-star property

Level Chicago Fulton Market

Oct 31 - Nov 5

5 night stay

Atlanta (ATL) to Chicago (ORD)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $1,045, price is now $594 per person
$594
per person
found 1 day ago
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Serena premium economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Chicago
4.0-star property

Hotel Riu Plaza Chicago

9.4/10 Exceptional! (2,427 reviews)

Nov 7 - Nov 11

4 night stay

Miami (MIA) to Chicago (ORD)

Delta • Non-stop roundtrip • PremiumEconomy
Price was $1,110, price is now $766 per person
$766
per person
found 1 day ago
One day didn’t receive room service

Reviewed on Sep 2, 2025

Trump International Hotel & Tower Chicago
5.0-star property

Trump International Hotel & Tower Chicago

9.4/10 Exceptional! (1,716 reviews)

Nov 7 - Nov 11

4 night stay

Miami (MIA) to Chicago (ORD)

Delta • Non-stop roundtrip • PremiumEconomy
Save 100% on your flight
Price was $1,803, price is now $1,273 per person
$1,273
per person
found 1 day ago
Every employee makes every guest feel like a rockstar. Commitment to quality and guest experience is evident.

Reviewed on Sep 14, 2025

Swissotel - Chicago
4.5-star property

Swissotel - Chicago

9/10 Wonderful! (2,765 reviews)

Nov 7 - Nov 11

4 night stay

Miami (MIA) to Chicago (ORD)

Delta • Non-stop roundtrip • PremiumEconomy
Price was $1,069, price is now $772 per person
$772
per person
found 1 day ago
All around a great location with incredible views. We stayed in a king suite on the 30th floor with views of both the city and lake thanks to architect that designed the building as a triangle that overlooks the Chicago river.

Reviewed on Sep 3, 2025

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Serena first class flight packages

Price found within the past 48 hours. Click for updated prices.
Claridge House
4.0-star property

Claridge House

9/10 Wonderful! (1,367 reviews)

Oct 31 - Nov 3

3 night stay

San Francisco (SFO) to Chicago (ORD)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,415, price is now $1,289 per person
$1,289
per person
found 4 hours ago
Nice property and large, clean, comfortable room. A bit loud one of the nights but not the hotel’s issue. Staff was super helpful. I’d stay again.

Reviewed on Sep 4, 2025

21c Museum Hotel Chicago
4.0-star property

21c Museum Hotel Chicago

8.8/10 Excellent! (1,626 reviews)

Oct 31 - Nov 3

3 night stay

San Francisco (SFO) to Chicago (ORD)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,637, price is now $1,478 per person
$1,478
per person
found 4 hours ago
Front desk staff were very welcoming and kind. Cleaning staff was amazing!

Reviewed on Aug 4, 2025

Silversmith Hotel Chicago Downtown
4.0-star property

Silversmith Hotel Chicago Downtown

9.4/10 Exceptional! (1,980 reviews)

Oct 31 - Nov 3

3 night stay

San Francisco (SFO) to Chicago (ORD)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,548, price is now $1,416 per person
$1,416
per person
found 4 hours ago
This was my second time staying at Silversmith. Love the location of the hotel. I wish I remember the name of the woman who checked us in but the whole staff is fantastic. I have had nothing but good experiences when staying here. Will be my go to hotel for Chicago.

Reviewed on Sep 9, 2025

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.