Charleston Vacation Homes

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Featured Vacation Homes in Charleston

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Charleston

    Super 8 by Wyndham Charleston/Sikeston East MO

    Super 8 by Wyndham Charleston/Sikeston East MO

    310 S Story St, Charleston, MO
    $64 nightly
    The price is $71 total per night from May 18 to May 19
    $71 total
    May 18 - May 19
    Total includes taxes and fees
    6.6/10 (552 reviews)
    Quality Inn Charleston - Sikeston

    Quality Inn Charleston - Sikeston

    102 Drake St, I-57 Exit 10, Charleston, MO
    $66 nightly
    The price is $73 total per night from Jun 1 to Jun 2
    $73 total
    Jun 1 - Jun 2
    Total includes taxes and fees
    Eagle Inn Charleston

    Eagle Inn Charleston

    2811 East Marshall Street, Charleston, MO
    $64 nightly
    The price is $71 total per night from May 12 to May 13
    $71 total
    May 12 - May 13
    Total includes taxes and fees

Charleston Vacation Homes

Book vacation homes in Charleston
Next time you take a group getaway top Charleston, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Charleston vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Charleston vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Charleston; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Charleston rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Charleston is sure to be a winner.

Charleston Vacation Homes essential information

Accommodation
28 Vacation Homes
Lowest Price
$71 total
Highest Price
$505 total
Popular accommodation
Serenity South -- Gardens, River-Views, and Refreshing Space, 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool, 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More, Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi, Quaint, Beautiful Home next to SEMO and Hospital, Welcome campers, hikers, fishermen, girls' weekend wine getaways!!, "Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau, Little Blue Cottage on Spanish, Urban 2-bedroom Escape in Downtown Cape Girardeau