COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

Car Rentals in Key Largo from $19

I have a discount code

Reserve your car fast and hassle-free on the free Orbitz app

Free cancellation on most cars, plus option to book now and pay later

Read verified reviews from travelers like you!

Top Car Deals in Key Largo

Standard Commercial Van/Truck

  • 2 people
  • Unlimited mileage
TAVERNIER, USA

$19

per day
found 14 hours ago

Special

  • 5 people
  • Unlimited mileage
KEY LARGO, USA

$23

per day
found 14 hours ago

Compact

  • 5 people
  • Unlimited mileage
KEY LARGO, USA

$23

per day
found 14 hours ago

Economy

  • 4 people
  • Unlimited mileage
Key Largo, Florida, USA

$23

per day
found 14 hours ago

Midsize

  • 5 people
  • Unlimited mileage
KEY LARGO, USA

$24

per day
found 14 hours ago

Fullsize

  • 5 people
  • Unlimited mileage
Key Largo, Florida, USA

$25

per day
found 14 hours ago

Premium

  • 5 people
  • Unlimited mileage
Key Largo, Florida, USA

$26

per day
found 14 hours ago

Luxury

  • 5 people
  • Unlimited mileage
Key Largo, Florida, USA

$30

per day
found 14 hours ago

Compact Elite Crossover

  • 5 people
  • Unlimited mileage
Miami, Florida, USA

$43

per day
found 6 hours ago

Don't see what you're looking for?

See all car rentals in Key Largo
View all cars
Lowest prices found within the past 14 hours. Prices and availability subject to change. Additional terms may apply.

Find the best car rental deals in Key Largo, Florida

Key Largo is an island paradise that’s just a short drive from the mainland. With the freedom of your own wheels, you can go from shopping downtown to snorkeling or diving in the John Pennekamp Coral Reef State Park in a single day. Also, visit the Dagny Johnson Key Largo Hammock Botanical State Park and the Florida Keys Wild Bird Center.

There are car rental firms located near the center of town on the Overseas Highway, including Budget, Enterprise and Avis. Orbitz can help you choose your best option. If you’re arriving at Miami International Airport, book a flexible package and drive straight from your flight to the sparkling beach.

Key Largo and beyond: Three destinations by car

Key Largo is a great starting point for some of the most scenic drives in America. Here are three spots to discover by car.

Islamorada

For a short road trip, head to relaxing Islamorada. It’s home to the 11-acre Indian Key Historic State Park, with mangrove hammocks, shipwrecks and nature trails to explore. Swim with dolphins at Theatre of the Sea and hand-feed massive tarpon at Robbie’s Marina. For shopping, stop by the Morada Way Arts and Cultural District.

Journey time: Around 20 minutes

Distance: Approximately 17 miles

Everglades National Park

Hit the road early to spend a day exploring more than 607,000 hectares of wilderness in the Everglades National Park. The World Heritage Site features diverse landscapes including marshes, swamps and mangroves. They’re home to rare species, such as the manatee and alligator, so stop to join a ranger-led tour and make the most of wildlife spotting.

Journey time: Around 50 minutes

Distance: Approximately 40 miles

Key West

Jump in the car to travel the length of the spectacular Overseas Highway, to Key West. The southernmost point of the United States is famous for its pastel architecture, as well as cool nightlife and dining on Duval Street. Park the car to visit the Ernest Hemingway Home and Museum and the quirky Key West Cemetery.

Journey time: Around 2 hours

Distance: Approximately 100 miles