Book 5 Star Hotels in Southeast Missouri

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Nov 25 - Nov 26
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Check prices in Southeast Missouri for tonight, Nov 25 - Nov 26
Nov 26 - Nov 27
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Featured Southeast Missouri 5 Stars Hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$90 nightly
The price is $102 total per night
$102 total
Dec 1 - Dec 2
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$52 nightly
The price is $59 total per night
$59 total
Dec 1 - Dec 2
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
$106 nightly
The price is $120 total per night
$120 total
Nov 26 - Nov 27
Total with taxes and fees
Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and wedding services.
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
$76 nightly
The price is $80 total per night
$80 total
Nov 30 - Dec 1
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.79 mi from city center
$70 nightly
The price is $79 total per night
$79 total
Nov 30 - Dec 1
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy free WiFi in public areas, a 24-hour business center, and a TV in a common area. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations.
Breakfast included
Pet friendly
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
$84 nightly
The price is $91 total per night
$91 total
Nov 26 - Nov 27
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a banquet hall.
Pool
Breakfast included
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
Free Cancellation
30.18 mi from city center
$99 nightly
The price is $112 total per night
$112 total
Dec 1 - Dec 2
Total with taxes and fees
At Holiday Inn Poplar Bluff by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and concierge services. Additional amenities include meeting rooms, conference space, and a business center.
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
Free Cancellation
Reserve now, pay when you stay
83.3 mi from city center
$86 nightly
The price is $97 total per night
$97 total
Nov 26 - Nov 27
Total with taxes and fees
Guests of The Farmstead Hotel enjoy features like a casino, free WiFi in public areas, and microwave in a common area. A stay here includes free parking. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include an ATM and a TV in a common area.
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
54.5 mi from city center
$63 nightly
The price is $72 total per night
$72 total
Nov 30 - Dec 1
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in Southeast Missouri

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Southeast Missouri. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Southeast Missouri hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Southeast Missouri 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Southeast Missouri with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $59 to $120
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 612 5 star hotels in Southeast Missouri!

Southeast Missouri hotels essential information

Accommodation
612 hotels
Lowest Price
$59
Highest Price
$120
Popular hotels
Drury Plaza Hotel Cape Girardeau Conference Center, Baymont Inn and Suites by Wyndham Farmington, MO, The Riverview, Motel 6 Poplar Bluff, MO, Pear Tree Inn Cape Girardeau West, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Holiday Inn Poplar Bluff by IHG, The Farmstead Hotel, Days Inn and Suites by Wyndham Sikeston

Recent Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

5/5 Excellent
"It was fine "
A verified traveler stayed at Pear Tree Inn Cape Girardeau West
Posted 2 days ago
Pear Tree Inn Cape Girardeau West

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