Book 2 Star Hotels in O Brien
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Featured O Brien 2 Stars Hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
9.11 mi from city center
At this vacation home, guests have access to an arcade/game room, laundry facilities, and a garden. This family-friendly vacation home also has barbecue grills.
Kitchen
Washer

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
9.17 mi from city center
This vacation home offers an arcade/game room, express check-in, and express check-out. Additional amenities include laundry facilities, barbecue grills, and a garden.
Kitchen
Washer

Comfort Suites Lake City
3690 W Us Highway 90, Lake City, FL
Free Cancellation
Reserve now, pay when you stay
17.73 mi from city center
Guests staying at Comfort Suites Lake City enjoy an outdoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a meeting room, and a computer station.
Pool
Breakfast included

Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
Free Cancellation
Reserve now, pay when you stay
17.89 mi from city center
At Best Western Plus Lake City, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a 24-hour business center, coffee/tea in a common area, and express check-out.
Pool
Breakfast included

Tru by Hilton Lake City
284 NW Centurion Court, Lake City, FL
Free Cancellation
Reserve now, pay when you stay
17.91 mi from city center
Guests of Tru by Hilton Lake City have access to an outdoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff standing by to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include a 24-hour business center, coffee/tea in a common area, and express check-in.
Pool
Breakfast included

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
Free Cancellation
Reserve now, pay when you stay
18.21 mi from city center
Guests of La Quinta Inn & Suite by Wyndham Lake City have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, laundry facilities, and a vending machine.
Pool
Breakfast included

Postcard Cabins Gilchrist Springs
1699 NE Co Rd 337, High Springs, FL
24.65 mi from city center
If you drive, take advantage of free parking. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls.
Kitchen
Pet friendly

Holiday Inn Express Hotel & Suites LIVE OAK by IHG
6694 Us Highway 129, Live Oak, FL
Free Cancellation
20.02 mi from city center
Guests staying at Holiday Inn Express Hotel & Suites LIVE OAK by IHG enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD, Alachua, FL
Free Cancellation
29.91 mi from city center
Guests of Holiday Inn Express & Suites Alachua - Gainesville Area by IHG have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. A stay here includes free parking. The front desk has multilingual staff on hand 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a hot tub, a business center, and coffee/tea in a common area.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
O Brien hotels essential information
Accommodation | 323 hotels |
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Lowest Price | |
Highest Price | |
Popular hotels | Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!, MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY, La Quinta Inn & Suite by Wyndham Lake City, Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, Best Western Plus Lake City, Tru by Hilton Lake City, Holiday Inn Express Hotel & Suites LIVE OAK by IHG, Postcard Cabins Gilchrist Springs, Comfort Suites Lake City |
Recent Reviews

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
5/5 Excellent
"Always stay here when visiting my daughter in High Springs. Hotel is new, clean, and comfortable. Check-in is always smooth and pleasant. Breakfast is delicious too. "
A verified traveler stayed at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Posted 9 hours ago