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Fri, Apr 24 - Mon, Apr 27
AVL
Asheville Regional
SFO
San Francisco Intl.
$531 Roundtrip, found 14 hours ago
$531
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Apr 24 from Asheville Regional to San Francisco Intl., returning Mon, Apr 27, priced at $531 found 14 hours ago
Fri, Apr 24 - Sun, Apr 26
GSP
Greenville-Spartanburg Intl.
SJC
Norman Y. Mineta San Jose Intl.
$558 Roundtrip, found 2 days ago
$558
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Apr 24 from Greenville-Spartanburg Intl. to Norman Y. Mineta San Jose Intl., returning Sun, Apr 26, priced at $558 found 2 days ago
Sat, Jul 25 - Tue, Aug 4
AVL
Asheville
SFO
San Francisco
$349 Roundtrip, found 7 hours ago
$349
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Jul 25 from Asheville to San Francisco, returning Tue, Aug 4, priced at $349 found 7 hours ago
Thu, May 14 - Sat, May 16
AVL
Asheville
SFO
San Francisco
$367 Roundtrip, found 2 days ago
$367
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, May 14 from Asheville to San Francisco, returning Sat, May 16, priced at $367 found 2 days ago
Thu, Jun 11 - Tue, Jun 16
GSP
Greenville
SJC
San Jose
$372 Roundtrip, found 5 days ago
$372
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Thu, Jun 11 from Greenville to San Jose, returning Tue, Jun 16, priced at $372 found 5 days ago
Fri, May 8 - Wed, May 13
AVL
Asheville
SFO
San Francisco
$377 Roundtrip, found 3 days ago
$377
Roundtrip
found 3 days ago
Select United flight, departing Fri, May 8 from Asheville to San Francisco, returning Wed, May 13, priced at $377 found 3 days ago
Sat, May 9 - Sat, May 16
GSP
Greenville
SFO
San Francisco
$402 Roundtrip, found 3 days ago
$402
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, May 9 from Greenville to San Francisco, returning Sat, May 16, priced at $402 found 3 days ago
Price found within the past 48 hours. Click for updated prices.
DoubleTree by Hilton San Francisco South Airport Blvd
4.0-star property

DoubleTree by Hilton San Francisco South Airport Blvd

8.4/10 Very Good! (2,196 reviews)

May 20 - May 25

5 night stay

Greenville (GSP) to San Francisco (SFO)

Southwest Airlines • Coach

San Francisco (SFO) to Greenville (GSP)

American Airlines • Coach
Price was $1,048, price is now $778 per person
$778
per person
found 1 day ago
Amazing and clean and cookies are delicious

Reviewed on Jan 25, 2026

Hotel Zetta San Francisco
4.0-star property

Hotel Zetta San Francisco

8.8/10 Excellent! (1,000 reviews)

Jun 2 - Jun 7

5 night stay

Greenville (GSP) to San Francisco (SFO)

Delta • Non-stop • Coach

San Francisco (SFO) to Greenville (GSP)

Southwest Airlines • Non-stop • Coach
Save 100% on your flight
Price was $2,033, price is now $1,464 per person
$1,464
per person
found 11 hours ago
The staff was great, and my stay was much better than I expected.

Reviewed on Feb 24, 2022

The Donatello
3.5-star property

The Donatello

9.2/10 Wonderful! (1,000 reviews)

May 20 - May 25

5 night stay

Greenville (GSP) to San Francisco (SFO)

Southwest Airlines • Coach

San Francisco (SFO) to Greenville (GSP)

American Airlines • Coach
Price was $1,355, price is now $1,003 per person
$1,003
per person
found 1 day ago
Great room and amnenities.

Reviewed on Mar 4, 2026

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Frequently asked questions

What is the shortest flight from Greenville - Spartanburg to San Francisco?
From Greenville - Spartanburg, the exciting sights and sounds of San Francisco are at least 5 hours and 54 minutes away. Secure your favorite seat, or maybe even upgrade to one with extra legroom, and travel to your destination in comfort.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.