St. Louis Vacation Homes

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in St. Louis

Don't see what you're looking for?
See all available properties in St. Louis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. Louis

    Hyatt Regency St. Louis at The Arch

    Hyatt Regency St. Louis at The Arch

    315 Chestnut St St. Louis MO
    $144 nightly
    The price is $169 total per night from Jun 28 to Jun 29
    $169 total
    Jun 28 - Jun 29
    Total with taxes and fees
    8.6/10 Excellent! (4,094 reviews)
    Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

    Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

    1088 South Highway Drive Fenton MO
    $99 nightly
    The price is $115 total per night from Jun 2 to Jun 3
    $115 total
    Jun 2 - Jun 3
    Total with taxes and fees
    7.8/10 Good! (1,320 reviews)
    Pear Tree Inn St. Louis Near Union Station

    Pear Tree Inn St. Louis Near Union Station

    2211 Market Street St. Louis MO
    $122 nightly
    The price is $143 total per night from Jun 7 to Jun 8
    $143 total
    Jun 7 - Jun 8
    Total with taxes and fees
    8.8/10 Excellent! (1,984 reviews)

St. Louis Vacation Homes

Book vacation homes in St. Louis
Next time you take a group getaway top St. Louis, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. Louis vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. Louis vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. Louis; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. Louis rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. Louis is sure to be a winner.

St. Louis Vacation Homes essential information

Accommodation
560 Vacation Homes
Lowest Price
$115
Highest Price
$434
Popular accommodation
Aurora Adobe in St. Louis Tremendous 3Bedroom House with AC, 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟, Centrally located in the Tower Grove East neighborhood!, Heart of The Hill Family & Pet Favorite!WashU, SLU, Barnes, Forest Park, Yard, Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi, Beautiful 4 bedroom Home by the Hill - Privacy Fenced Backyard and Fast Internet, Pet-Friendly Soulard Townhouse · 2BR/2BA · Parking + Rooftop Deck, Stunning 1890's Home - Sleeps 8! , Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

More to Explore