Hotels on the Lake in Santee
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Featured Santee Hotels on the Lake

Red Roof Inn Santee
9091 Old Hwy 6, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $72 total per night
$72 total
Aug 6 - Aug 7
Total includes taxes and fees
Red Roof Inn Santee features free WiFi in public areas, coffee in a common area, and express check-out. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. This smoke-free hotel also has a vending machine.
Breakfast included
Pet friendly

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$115 nightly
The price is $127 total per night
$127 total
Aug 12 - Aug 13
Total includes taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included

Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$132 nightly
The price is $147 total per night
$147 total
Aug 17 - Aug 18
Total includes taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included

Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$101 nightly
The price is $112 total per night
$112 total
Aug 12 - Aug 13
Total includes taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee hotels essential information
Accommodation | 231 hotels |
---|---|
Lowest Price | $72 |
Highest Price | $147 |
Popular hotels | Red Roof Inn Santee, Best Western Plus Santee Inn, Hampton Inn Santee-I-95, Comfort Inn & Suites Santee |
Recent Hotels on the Lake Reviews

Hampton Inn Santee-I-95
5/5 Excellent
surprise in Santee
"Loved this hotel. The staff could not be friendlier and helpful. The room was immaculate, and the layout was unique and spacious. The water pressure was very good (I love a good shower) and the beds were quite comfortable. I did have an issue with the thermostat - it seemed to go on auto pilot in the middle of the night. But that may have been user error. Front desk recommendation for dinner was perfect."
A verified traveler stayed at Hampton Inn Santee-I-95
Posted 1 day ago
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