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Featured Santee 2 Stars Hotels

Tru By Hilton Santee
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included

Baymont by Wyndham Santee
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$75 nightly
The price is $83 total per night
$83 total
Dec 28 - Dec 29
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly

Fairfield Inn & Suites by Marriott Santee
9074 Old Number Six Hwy Santee SC
0.62 mi from city center
$121 nightly
The price is $134 total per night
$134 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests staying at Fairfield Inn & Suites by Marriott Santee enjoy an outdoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included

Hampton Inn Santee-I-95
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.59 mi from city center
$133 nightly
The price is $148 total per night
$148 total
Jan 22 - Jan 23, 2026
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included

Comfort Inn & Suites Santee
221 Britain St Santee SC
Free Cancellation
Reserve now, pay when you stay
0.17 mi from city center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Free Cancellation
0.17 mi from city center
$104 nightly
The price is $115 total per night
$115 total
Dec 28 - Dec 29
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.
Pool
Pet friendly

Best Western Plus Santee Inn
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.56 mi from city center
$118 nightly
The price is $131 total per night
$131 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included

Quality Inn & Suites
8929 Old Number Six Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
0.14 mi from city center
$59 nightly
The price is $66 total per night
$66 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Quality Inn & Suites Santee I-95 features free WiFi in public areas, a seasonal outdoor pool, and microwave in a common area. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a refrigerator in a common area, a computer station, and laundry facilities.
Pool
Breakfast included

Travelodge by Wyndham Santee
9117 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.73 mi from city center
$61 nightly
The price is $68 total per night
$68 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Travelodge by Wyndham Santee features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and tours/tickets. Additional amenities include an ATM and a vending machine.
Breakfast included
Pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee hotels essential information
Accommodation | 305 hotels |
|---|---|
Lowest Price | $66 |
Highest Price | $148 |
Popular hotels | Tru By Hilton Santee, Baymont by Wyndham Santee, Fairfield Inn & Suites by Marriott Santee, Hampton Inn Santee-I-95, Comfort Inn & Suites Santee, Holiday Inn Santee by IHG, Best Western Plus Santee Inn, Quality Inn & Suites, Travelodge by Wyndham Santee |
Recent Reviews

Tru By Hilton Santee
5/5 Excellent
" the rooms are clean. The bed was comfortable. I liked the way they supply shampoo and conditioner and such in each room. Showers were nice and clean plenty of towels. Water pressure was good. Enjoyed our stay. We always try to stay at a true when traveling."
A verified traveler stayed at Tru By Hilton Santee
Posted 4 days ago


