
Southeast Missouri Vacation Packages
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3.5-star property
Holiday Inn St. Louis Arpt West-Earth City by IHG
7.6/10 Good! (1,001 reviews)
Jan 22 - Jan 25
3 night stay
San Antonio (SAT) to St. Louis (STL)
Southwest Airlines • Roundtrip • Coach
Price was $567, price is now $481 per person
$481
per person
found 1 day ago
Was nice stay. But not doors were secure at night
Reviewed on Nov 10, 2026


4.0-star property
The Cheshire
8.8/10 Excellent! (1,010 reviews)
Jan 22 - Jan 25
3 night stay
San Antonio (SAT) to St. Louis (STL)
Southwest Airlines • Roundtrip • Coach
Price was $786, price is now $654 per person
$654
per person
found 1 day ago
Our first impression when we walked into the room - drape wasn't hanging properly and needs to be fixed. Bottom dresser drawer wouldn't shut so needs repaired. Toliet seat needs fixed. Then toliet would not fill up when flushed. Couldn't get cold water from sink in bathroom. Light on the dresser switch was broken - could not turn light switch off.
Reviewed on Nov 13, 2026

2.5-star property
Country Inn & Suites by Radisson, St. Charles Historic District
St. Charles Historic District
9.4/10 Exceptional! (1,102 reviews)
Jan 22 - Jan 25
3 night stay
San Antonio (SAT) to St. Louis (STL)
Southwest Airlines • Roundtrip • Coach
Price was $660, price is now $571 per person
$571
per person
found 1 day ago
3 night stay in early Nov-2026. Location is very walkable to historic St. Charles and waterfront. Check in was great-there was a large group of people in front of me when I arrived and the desk clerk saw me and flagged me to the counter to help me around the group. She also suggested Salt & Smoke for dinner which I tried and it was good. Room and facilities were very clean, and the bed and pillows were very comfortable. It was very quiet, no street noise; this time of year may be less noisy than it would be in the summertime. Complimentary breakfast was good; when it was getting close to closing time the person managing the food actually asked me if I needed anything else before she shut down which was very considerate. Warm cookies in lobby were good. I recommend Napoli restarurant just a short drive away-very good!
Reviewed on Nov 12, 2026

3.5-star property
Hotel Indigo St Louis - Central West End by IHG
Central West End
8.8/10 Excellent! (1,006 reviews)
Jan 22 - Jan 25
3 night stay
San Antonio (SAT) to St. Louis (STL)
Southwest Airlines • Roundtrip • Coach
Price was $602, price is now $520 per person
$520
per person
found 1 day ago
Overall, our stay was okay. I would have liked a microwave in my room, an ice machine close by, and an explanation of the "energy" fee on my final invoice. Also, that location should not charge for parking. I felt "nickel and dimed" to death after this experience. Also, Housekeeping failed to put a flat sheet on one of our beds, so we requested a sheet and took care of it ourselves. Do better, IHG.
Reviewed on Nov 12, 2026
Top rated hotels for your Southeast Missouri vacation package

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$100 nightly
The price is $113 total per night
$113 total
Nov 15 - Nov 16
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
30.36 mi from city center
$89 nightly
The price is $100 total per night
$100 total
Dec 6 - Dec 7
Total with taxes and fees
Guests of Hampton Inn Poplar Bluff have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$54 nightly
The price is $62 total per night
$62 total
Nov 19 - Nov 20
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included
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See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do

Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
96% of travellers recommend

History Tour of Pythian Castle in Springfield Missouri
$13
per adult
90% of travellers recommend
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