Business Hotels in Opelousas, LA
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Opelousas Business Hotels

Holiday Inn Express & Suites Opelousas by IHG
5696 I-49 N Service Rd, Opelousas, LA
Free Cancellation
$125 nightly
The price is $147 total per night
$147 total
Nov 16 - Nov 17
Total with taxes and fees
Guests of Holiday Inn Express & Suites Opelousas by IHG have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included

Spark by Hilton Opelousas
5454 I-49 North Service Rd., Opelousas, LA
Free Cancellation
Reserve now, pay when you stay
$66 nightly
The price is $78 total per night
$78 total
Nov 30 - Dec 1
Total with taxes and fees
Renovated in 2025, Spark by Hilton Opelousas offers free WiFi in public areas, coffee in a common area, and express check-out. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Pool
Breakfast included

Days Inn & Suites by Wyndham Opelousas
5761 I-49 S Service Rd, Opelousas, LA
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $79 total per night
$79 total
Nov 11 - Nov 12
Total with taxes and fees
Days Inn & Suites by Wyndham Opelousas features an outdoor pool, free WiFi in public areas, and conference space. You can take advantage of free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include laundry facilities, a vending machine, and a banquet hall.
Pool
Breakfast included

Evangeline Downs Hotel, an Ascend Collection Hotel
2235 Creswell Ln Ext, Lot B, Opelousas, LA
Free Cancellation
$95 nightly
The price is $112 total per night
$112 total
Nov 30 - Dec 1
Total with taxes and fees
Guests of Evangeline Downs Hotel, an Ascend Collection Hotel enjoy a casino, a nightclub, and an indoor pool. You can put free parking to good use if you drive. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a gym, free WiFi in public areas, and a conference center.
Pool
Breakfast included

Studio 6 Opelousas, LA
5791 I-49 S Service Road, Opelousas, LA
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $77 total per night
$77 total
Nov 10 - Nov 11
Total with taxes and fees
At Studio 6 Opelousas, LA, guests have access to a vending machine. Free parking is included with your stay. The 24-hour front desk has staff always at the ready.
Pet friendly
Parking included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Opelousas hotels essential information
Accommodation | 416 hotels |
|---|---|
Lowest Price | $77 |
Highest Price | $147 |
Popular hotels | Holiday Inn Express & Suites Opelousas by IHG, Spark by Hilton Opelousas, Days Inn & Suites by Wyndham Opelousas, Evangeline Downs Hotel, an Ascend Collection Hotel, Studio 6 Opelousas, LA |
Recent Business Hotels Reviews

Motel 6 Opelousas, LA
5/5 Excellent
"The lady at the front desk Jasmine is absolutely phenomenal!! Always so sweet and nice !!!"
A verified traveler stayed at Motel 6 Opelousas, LA
Posted 3 days ago


