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Featured Vacation Homes in Frederick

Retreat on the Creek - Businees Travelor or Weekend Getaway. Historic District
Retreat on the Creek - Businees Travelor or Weekend Getaway. Historic District
Frederick, MD
$125
Guests staying at this vacation home enjoy features like a fitness center.
A Sweet Escape Just Moments From Downtown Fun
A Sweet Escape Just Moments From Downtown Fun
Frederick, MD
This vacation home is a smoke-free vacation home.
Charming "cream of the Crop" Cape ~of Middletown
Charming "cream of the Crop" Cape ~of Middletown
Middletown, MD
This vacation home is a smoke-free vacation home.
Quite Gem Near Downtown & DC
Quite Gem Near Downtown & DC
Frederick, MD
This vacation home is a smoke-free vacation home.
Gorgeous 1840 Log Cabin- Downtown
Gorgeous 1840 Log Cabin- Downtown
Frederick, MD
At this vacation home, guests have access to a garden.
Family Vacation on a Farm Near Washington DC, Baltimore, Gettysburg
Family Vacation on a Farm Near Washington DC, Baltimore, Gettysburg
Mount Airy, MD
At this vacation home, guests have access to a garden.
Walk to Potomac River and Downtown Harpers Ferry
Walk to Potomac River and Downtown Harpers Ferry
Knoxville, MD
Guests staying at this vacation home have access to a garden and barbecue grills.
Adorable 1940's Cottage Near Downtown, Hood College, Ft. Detrick
Adorable 1940's Cottage Near Downtown, Hood College, Ft. Detrick
Frederick, MD
This vacation home is a smoke-free vacation home.
Walk to the Canal and Downtown!!! Beautiful 1880 Fully Renovated Townhome
Walk to the Canal and Downtown!!! Beautiful 1880 Fully Renovated Townhome
Frederick, MD
This vacation home is a smoke-free vacation home.
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Frederick Vacation Homes

Book vacation homes in Frederick
Next time you take a group getaway top Frederick, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Frederick vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Frederick vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Frederick; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Frederick rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Frederick is sure to be a winner.

Hotel Options in Frederick

See all 100 Properties in Frederick
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.