$89 Cheap flights to Mississippi County

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Top places to visit in Mississippi County

Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.
FlightsFlights
FlightsFlights

Charleston

Charleston
The Mississippi River near Hannibal, Missouri, USA
FlightsFlights
FlightsFlights

East Prairie

East Prairie

Cheap flights to Mississippi County from $89 One Way, $178 Round Trip

$178 return flights and $89 one-way flights to Mississippi County were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 28 - Mon, Sep 7
ORD
Chicago
CGI
Cape Girardeau
$178 Roundtrip, found 1 day ago
$178
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Fri, Aug 28 from Chicago to Cape Girardeau, returning Mon, Sep 7, priced at $178 found 1 day ago
Thu, Aug 13 - Sun, Aug 16
ORD
Chicago
CGI
Cape Girardeau
$183 Roundtrip, found 15 hours ago
$183
Roundtrip
found 15 hours ago
Select Contour Airlines flight, departing Thu, Aug 13 from Chicago to Cape Girardeau, returning Sun, Aug 16, priced at $183 found 15 hours ago
Wed, Jul 8 - Tue, Jul 14
ORD
Chicago
PAH
Paducah
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jul 8 from Chicago to Paducah, returning Tue, Jul 14, priced at $199 found 1 day ago
Sun, Aug 30 - Sun, Sep 6
DFW
Dallas
CGI
Cape Girardeau
$218 Roundtrip, found 12 hours ago
$218
Roundtrip
found 12 hours ago
Select Contour Airlines flight, departing Sun, Aug 30 from Dallas to Cape Girardeau, returning Sun, Sep 6, priced at $218 found 12 hours ago
Sat, Jun 27 - Sun, Jun 28
EWR
New York
PAH
Paducah
$393 Roundtrip, found 14 hours ago
$393
Roundtrip
found 14 hours ago
Select United flight, departing Sat, Jun 27 from New York to Paducah, returning Sun, Jun 28, priced at $393 found 14 hours ago
Fri, Jul 3 - Tue, Jul 7
DEN
Denver
PAH
Paducah
$419 Roundtrip, found 6 days ago
$419
Roundtrip
found 6 days ago
Select United flight, departing Fri, Jul 3 from Denver to Paducah, returning Tue, Jul 7, priced at $419 found 6 days ago
Sat, Jun 27 - Sun, Jun 28
EWR
New York
PAH
Paducah
$440 Roundtrip, found 14 hours ago
$440
Roundtrip
found 14 hours ago
Select United flight, departing Sat, Jun 27 from New York to Paducah, returning Sun, Jun 28, priced at $440 found 14 hours ago
Fri, Jul 3 - Tue, Jul 7
DEN
Denver
PAH
Paducah
$465 Roundtrip, found 6 days ago
$465
Roundtrip
found 6 days ago
Select United flight, departing Fri, Jul 3 from Denver to Paducah, returning Tue, Jul 7, priced at $465 found 6 days ago
Fri, Jul 3 - Mon, Jul 6
DEN
Denver
PAH
Paducah
$471 Roundtrip, found 6 days ago
$471
Roundtrip
found 6 days ago
Select United flight, departing Fri, Jul 3 from Denver to Paducah, returning Mon, Jul 6, priced at $471 found 6 days ago
Sat, Jun 27 - Sun, Jun 28
EWR
New York
PAH
Paducah
$475 Roundtrip, found 14 hours ago
$475
Roundtrip
found 14 hours ago
Select United flight, departing Sat, Jun 27 from New York to Paducah, returning Sun, Jun 28, priced at $475 found 14 hours ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
ORDWest PaducahJune 20 to June 29$300
ORDWest PaducahJune 20 to June 29$300
ORDScott CityJune 20 to June 22$396
ORDScott CityJune 20 to June 22$396
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Mississippi County Accommodation Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $66 total per night from Jul 12 to Jul 13
$66 total
Jul 12 - Jul 13
Total with taxes and fees
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (641 reviews)
"The outside of the hotel needs some work The breakfast needed more than instant oatmeal for breakfast. Muffins wrapped separately would have been nice. Banana along with the apples. Cold cereals in little bowls. Just anything more than what they had."

Reviewed on Jun 11, 2026

Opens in a new windowSuper 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Jun 19 to Jun 20
$83 total
Jun 19 - Jun 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.8/10 (416 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."

Reviewed on Jun 7, 2026

Opens in a new windowThe Riverstone Hotel Charleston-Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $122 total per night from Jun 22 to Jun 23
$122 total
Jun 22 - Jun 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Jun 21 to Jun 22
$78 total
Jun 21 - Jun 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."

Reviewed on Jun 8, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Mississippi County

When you plan to buy tickets for flights to Mississippi County, you don’t have to look any further than Orbitz! We offer bargain rates and low fares on thousands of flights.

Reliable Customer Service

Along with our low prices, Orbitz is well known for exceptional customer care. We make it simple to find the best Mississippi County flights for you. If you need to cancel your booking or change your flight plans, simply contact our Customer Service department to make any adjustments.

Bargain Tickets for Mississippi County Flights

Orbitz offers deeply discounted flights to Mississippi County, and we provide the resources to research your travel destination and plan your complete itinerary.

Use Orbitz to Earn Points with Your Frequent Flyer Program

Saving your frequent flyer miles for your flights to Mississippi County? You can use Orbitz to make your budget ticket reservation for all your flights and still earn points or miles on your frequent flyer program! Just enter your program account number while you’re booking your ticket to have your points added automatically, every time you book with Orbitz.

Convenient Travel Planning Services

If you like the ease of making your travel plans on the move, you’ll love the free Orbitz apps for iPhones, iPads, and Android devices. You can use these apps to review your travel reservations or make a change to your itinerary. Orbitz also offers additional travel assistance such as free mobile alerts that keep you up-to-date about sudden changes to your upcoming flights. You can also browse Orbitz easily on your smartphone by using the mobile version of the website to find budget Mississippi County flights.

Frequently asked questions

Which airlines fly to Mississippi County?
Reserve a ticket with one of the 22 airlines that operate services to Nashville Intl. Airport (BNA) and come prepared for exciting new adventures. This popular airport is a major entrance point for Mississippi County. When you're ready to see this region, these reputable carriers will get you there:

  • Air Canada - 42 flights to Mississippi County per month
  • WestJet - 20 flights to Mississippi County per month
  • British Airways - 16 flights to Mississippi County per month

How much is a flight to Mississippi County?
Prices for return flights to Mississippi County this past week fluctuated from $178 to $475. If you were traveling one-way from Chicago (ORD), you could have snapped up tickets from as low as $89.
How to book the cheapest flight to Mississippi County?
Scoring cheap flights to Mississippi County is as easy as booking with Orbitz. But if you'd like to make sure you're walking away with the best flight deals around, here are some tips worth following:

  • Consider taking off from or landing at other airports to cut costs. Enter your preferred departure and arrival points in the form fields, then choose the 'Nearby airports' function below. It will list any available options.
  • If your travel plans aren't etched in stone, click on the 'Show flexible dates' link to see the flight deals across different departure dates. You may find a cheaper fare.
  • Hit 'Show options' to filter your search results. You can choose your preferred airline and seating class here. Under 'Sort & Filter' to the left, you can even select whether you want to fly in the morning, afternoon or evening.
  • Reserve your seat as soon as you've figured out your travel dates. While it does happen on occasion, tickets rarely fall in price as your departure date nears.
  • Save even more on your trip by bundling your hotel, flights and car rental into a package. Your wallet will thank you.
  • Don't fly during peak seasons if possible. By steering clear of school vacations and summer, you can save big on your airfare.

What is the best time to book a flight to Mississippi County?
Pick up a bargain and book your tickets to Mississippi County in January. If you've missed this month, don't stress. February and August often have affordable airfares too. Be careful not to sleep on a sale though — cheap flights emerge and disappear in a flash!
What day of the week is the cheapest to book a flight to Mississippi County?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book flights to Mississippi County. If you're looking for unbeatable airfares, search across those days and you're likely to pick up a fantastic flight deal.
What is the cheapest day of the week to fly to Mississippi County?
You can pick up cheap flights to Mississippi County by taking to the skies on a Monday, according to Orbitz data from 2020. Tuesday is also more affordable, while Saturday has the most costly ticket prices. Whether you prefer to save money or start your trip on any day that's convenient, you'll always find a rewarding deal with Orbitz.
What is the cheapest month to fly to Mississippi County?
To secure cheap flights to Mississippi County, you should take off in August. If getting a great deal on your ticket is your number one priority, Orbitz data shows that this is generally an excellent month to take a trip. June is when fares are at their peak.
Which airlines allow free cancellation?
If you're worried your travel plans may change, Orbitz will help you find a flexible fare. All you have to do is select "Filter by flexible change policies" when searching for your flights. We'll show you airlines that include free cancellation and no change fees — all on top of our awesome low prices.
What do I need for the flight to Mississippi County?
The secret to a comfortable and stress-free flight is being well prepared. Listed below are some handy tips to help you get ready for your trip:

  • Your travel documents are the most important things you'll need to have with you on your flight. To avoid any issues during check-in, make sure that the personal information on your ticket is correct and matches your government-issued ID.
  • Take some activities to pass the time on your journey to Mississippi County. Books and electronic devices like e-readers and laptops are perfect. Don't forget to take a bottle of water as well. Even on a short flight, it's important to keep hydrated.
  • No matter the weather outside, plane cabins can get cold. Take a sweater on board to keep yourself cozy.

How do I get cheap first-class/business deals to Mississippi County?
Experienced travelers are pros at finding first or business-class airfares to Mississippi County without the astronomical price tag. You can do the same with these useful hints:

  • Flexibility is essential. By being open to a variety of travel dates, you'll have better odds of spotting a sale on business or first-class airfares.
  • Many low-cost airlines these days have quality business or premium-class seating that doesn't cost an arm and a leg.
  • Make the most of your airline's loyalty program and upgrade your seat. Alternatively, you can try bidding for an upgrade in an online auction.

What is the best time to go to Mississippi County?
If you want to soak up the culture of Mississippi County in the tourist season, March, April and June are the prime months to visit. June 20 marks the beginning of summertime in the Northern Hemisphere and is a perfect time to go if you relish the open air. Around this time of year, average daily temperatures generally range from 70 ºF to 85 ºF.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.