$27 Cheap flights to Madre de Dios Region

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap flights to Madre de Dios Region from $27 One Way, $53 Round Trip

$53 return flights and $27 one-way flights to Madre de Dios Region were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
CUZTambopataNovember 22 to December 2$61
LIMTambopataNovember 21 to November 24$184
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Our Top Madre de Dios Region Apartment Hotels

CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr., La Pradera Puerto Maldonado, Tambopata, Madre de Dios
Stay at this 3.5-star business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

Opens in a new windowCHIMICUAS HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Madre de Dios Region Accommodation Deals

Libelula Hotel

Libelula Hotel

2 out of 5
Jr Puno No. 429, Tambopata, Madre de Dios
Stay at this hostal in Tambopata. Enjoy free WiFi, daily housekeeping, and cable TV channels. Popular attractions Puerto Maldonado Plaza de Armas and Maldonado ...
8.8/10 Excellent! (19 reviews)
Great stay, friendly owners and staff.

Reviewed on Jun 22, 2025

Opens in a new windowLibelula Hotel
IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo, Tambopata, Madre de Dios
$218 nightly
The price is $218 total per night from Nov 21 to Nov 22
$218 total
Nov 21 - Nov 22
Stay at this 3-star all-inclusive hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado ...
9/10 Wonderful! (6 reviews)
Half an hour a at from Puerto Maldonado by boat , the place is lovely, with river view and a feel of the jungle without venturing too far. We felt like we got a good insight into the area, with included excursions on the river and into the jungle. Our guide Yuri, who was with us throughout, was very ...

Reviewed on Sep 23, 2025

Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Inkaterra Reserva Amazonica

Inkaterra Reserva Amazonica

4 out of 5
Madre De Dios River Km. 15, Las Piedras, Madre de Dios
Stay at this 4-star spa hotel in Las Piedras. Enjoy free breakfast, a full-service spa, and a free airport shuttle. Popular attractions Island of Monkeys and ...
9.2/10 Wonderful! (43 reviews)
World class!

Reviewed on Oct 19, 2025

Opens in a new windowInkaterra Reserva Amazonica
Save an average of 15% on thousands of hotels when you're signed in
Posada Amazonas

Posada Amazonas

3 out of 5
Infierno Native Community, Tambopata, Madre De Dios
$978 nightly
The price is $978 total per night from Nov 21 to Nov 22
$978 total
Nov 21 - Nov 22
Stay at this 3-star spa inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Collpa Hermosa and ...
9.6/10 Exceptional! (13 reviews)
Jungle Adventure
Posadas was a lovely jungle lodge. The staff were friendly and helpful with amazing service. Beautiful setting and Rainforest Expeditions made our transportation and excursions smooth and flawless. Food was fresh and delicious satisfying to the taste buds. The jungle sounds were wonderful to wake ...

Reviewed on Oct 8, 2025

Opens in a new windowPosada Amazonas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Madre de Dios Region

Refugio Amazonas
Great for families

Refugio Amazonas

3 out of 5
Rio Tambopata, Tambopata, Madre de Dios
$918 nightly
The price is $918 total per night from Nov 16 to Nov 17
$918 total
Nov 16 - Nov 17
Stay at this 3-star family-friendly inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Condemned ...

Families like: Kids club, playground, babysitting, bicycle rentals

Travelers say...
Our experience was amazing! This was an experience that I have always dreamed about. The guides for the excursions were the best. They were so knowledgeable and friendly. I will never forget all the beautiful sounds that you wake up to in the rainforest. The lodge was very eco friendly and the rooms ...

Reviewed on Apr 4, 2022

Opens in a new windowRefugio Amazonas
 Andean Wings Sotupa Eco Lodge
Great for families

Andean Wings Sotupa Eco Lodge

2 out of 5
Carretera Tambopata Km 11,5, Bajo Tambopata, Tambopata, Madre de Dios
Book a stay at this beach guesthouse in Tambopata. Enjoy free breakfast, free parking, and a free beach shuttle. Popular attractions Puerto Capitanía and Puerto ...
8/10 Very Good! (4 reviews)

Families like: Outdoor pool, game room, close to beach, bicycle rentals

Travelers say...
The property itself is very well built we were surprised we had no issues with bugs inside the room! The view from our room was great also. This was our first time in PM so we didn’t know what to expect, but thought there would be more things to do there for what we paid. We also thought there would ...

Reviewed on Apr 26, 2025

Opens in a new window Andean Wings Sotupa Eco Lodge
CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr., La Pradera Puerto Maldonado, Tambopata, Madre de Dios
Stay at this 3.5-star business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

Opens in a new windowCHIMICUAS HOUSE
Save an average of 15% on thousands of hotels when you're signed in
Ecolucerna Lodge Tambopata
Great for families

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata, Puerto Maldonado, Tambopata, Madre de Dios
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
10/10 Exceptional! (4 reviews)

Families like: Playground, game room, close to beach, free breakfast for the whole family

Travelers say...
we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing!

Reviewed on Oct 29, 2025

Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Madre de Dios Region

Start your search for cheap flights to Madre de Dios Region on Orbitz. Orbitz is where you will discover guaranteed low prices on Madre de Dios Region flights, as well as all of the following conveniences:

Travel Updates on Your Mobile Device

Orbitz offers cutting-edge mobile tools for your smartphone. Whether you own an iPhone or an Android phone, you can benefit from Orbitz’s flight status updates and even book your future Madre de Dios Region flights. You can also review and reserve hotel rooms for when your Madre de Dios Region flights land and see other special offers.

Low Prices Guaranteed on Flights to Madre de Dios Region

Orbitz offers large discounts on a wide range of Madre de Dios Region flights. Through our easy-to-use site, you can find, plan, and reserve your desired flights to Madre de Dios Region while taking advantage of the lowest fares around.

Customer Care When You Need It

Orbitz is dedicated to making your flight booking experience as stress-free as possible. If you need to cancel your reservation, you can do so at your own convenience by going to the Orbitz website. If you need to change your flights to Madre de Dios Region to another time or date, you can contact our customer service representatives by phone, and they help you make the flight adjustments you need.

Loyalty Program Participation Opportunities

Orbitz lets you add your loyalty or frequent flyer account numbers when you book qualifying flights to Madre de Dios Region. So don’t worry about missing out on earning miles or points simply because you aren’t booking with the airline directly. You can save on your flights, and rack up miles too.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.