De Soto Vacation Homes

Start date: Check-in selected.
To Date
End date: Check-out

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in De Soto

Don't see what you're looking for?
See all available properties in De Soto
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in De Soto

    82 Acre Hobby Farm with Lincoln Log Cabin

    82 Acre Hobby Farm with Lincoln Log Cabin

    De Soto MO
    $257 nightly
    The price is $266 total per night from Jan 3 to Jan 4
    $266 total
    Jan 3 - Jan 4
    Total with taxes and fees
    10/10 Exceptional! (40 reviews)
    Secluded cabin on private property

    Secluded cabin on private property

    De Soto MO
    10/10 Exceptional! (62 reviews)
    Pear Tree Inn St. Louis Arnold

    Pear Tree Inn St. Louis Arnold

    1201 Drury Ln Arnold MO
    $90 nightly
    The price is $104 total per night from Jan 6 to Jan 7
    $104 total
    Jan 6 - Jan 7
    Total with taxes and fees
    9.2/10 Wonderful! (1,004 reviews)

De Soto Vacation Homes

Book vacation homes in De Soto
Next time you take a group getaway top De Soto, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of De Soto vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every De Soto vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in De Soto; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a De Soto rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to De Soto is sure to be a winner.

De Soto Vacation Homes essential information

Accommodation
64 Vacation Homes
Lowest Price
$104
Highest Price
$300
Popular accommodation
In the Country a Beautiful 2-bedroom house with its own private lake, Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten., The Shack- 3 bedroom finished house, Cute town house with fenced backyard, Peter Ray House, Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill, Adorable small house - quiet & safe - 2 BR 1 Bath, Cozy Barn Loft in Farmington, Missouri, Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis

More to Explore