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Top Rated Cairo Hotels

Estimated price for 1 night/2 adults

Quality Inn Cairo I-57
Quality Inn Cairo I-57
2.5 out of 5.0 13201 Kessler Road, Cairo, IL
Free Cancellation
$57
4.3/5 (3 reviews)

super nice staff, went an extra mile to make us feel confortable, since we arrived very late

Reviewed on Sep 24, 2018
Quality Inn Cairo I-57 features free WiFi in public areas, coffee in a common area, and free newspapers. You'll find RV, bus, and truck parking. Front-desk staff ...
Quality Inn Charleston
Quality Inn Charleston
2.5 out of 5.0 102 Drake St, I-57 Exit 10, Charleston, MO
Free Cancellation
$61
4.2/5 (6 reviews)

Overall for one night not bad. Didn't expect rat traps outside the doors. As well as a plunger outside a room 3 doors down from me. The staff was very friendly. The room was clean. The bathroom looked dirty. Not sure if it was the shower walls were dirty or that's just the way they were.

Reviewed on Jun 12, 2018
Guests of Quality Inn Charleston enjoy access to free WiFi in public areas, a business center, and coffee in a common area. If you plan to drive, free parking ...
Super 8 by Wyndham Charleston MO
Super 8 by Wyndham Charleston MO
2.0 out of 5.0 310 S Story St, Charleston, MO
Free Cancellation
$54
3.6/5 (12 reviews)

Its a nice place to stay. I stay here about 2-3 times a year and I have never had a problem here. Friendly staff and right off the interstate.

Reviewed on Nov 19, 2018
Super 8 by Wyndham Charleston MO features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. ...
Eagle Inn Charleston
Eagle Inn Charleston
2.0 out of 5.0 2811 East Marshall Street, Charleston, MO
Free Cancellation
$50
2.5/5 (2 reviews)

Needs some serious improvement , very outdated everything was just really old and worn out. A good deep cleaning was really needed.

Reviewed on Sep 20, 2018
A health club and free WiFi in public areas are features at Eagle Inn Charleston. A stay here includes free parking. Front-desk staff are standing by 24/7 to ...
Americas Best Value Inn Ullin Mounds
Americas Best Value Inn Ullin Mounds
2.0 out of 5.0 128 Cheekwood Lane, Ullin, IL
Free Cancellation
$69
At Americas Best Value Inn Ullin Mounds, guests have access to an indoor pool, free WiFi in public areas, and a business center. Free parking is included with ...
Beautiful Cabin Retreat
Beautiful Cabin Retreat
Tamms, Illinois
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This lodge is a smoke-free lodge.
Quiet Country Cottage on Family Farm, 30 min From Paducah
Quiet Country Cottage on Family Farm, 30 min From Paducah
Bardwell, Kentucky
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Situated in a rural location, this cottage is within 25 mi (40 km) of Columbus-Belmont State Park, Ice House Gallery, and Fort Defiance. Kess Creek Park and ...
2017 Eclipse Rooms For Rent!
2017 Eclipse Rooms For Rent!
East Prairie, Missouri
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This vacation home is a smoke-free vacation home.
Beautiful & Secluded 2,400 Sqft Lodge With 4 BR & 2 BA + all the Amenities!
Beautiful & Secluded 2,400 Sqft Lodge With 4 BR & 2 BA + all the Amenities!
Bardwell, Kentucky
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At this lodge, guests have access to a garden.

Pet Friendly Cairo Hotels

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Estimated price for 1 night/2 adults

Finding a Hotel in Cairo


So you're considering a holiday to Cairo? If you want a place to lay your head that's located close to Cairo attractions, use Orbitz to pick your travel dates, and then presto! Review the list of hotels and other accommodations to identify those that are close to what you want to see.


There are 8 accommodations to pick from within the larger area if you can't find a place you want to stay in Cairo. Search by filters such as price, neighborhood, guest rating, or popular locations, depending on what's most important to you.


We make it easy to find a convenient flight to Cairo, IL (CIR-Cairo Regional), which is 1.8 mi (2.9 km) from the city center. Find the ideal flight in a flash by using the filters on our site to narrow down your search.


Accommodations in Cairo


There might be just a few hotels and accommodations to choose from in Cairo, but here are more options located close by to give you some choices.

  • 8 hotels in Miner
  • 10 hotels in Sikeston
  • 18 hotels in Cape Girardeau

What's the Weather Like in Cairo?


Debating whether you're going to need a lightweight jacket or a down coat while you're visiting? Cairo is typically warmest in July and June, while it’s usually the chilliest in January and December. The rainiest months are May and April, while the driest months are normally August and September. Here's a summary of rain and seasonal temperatures so you're completely prepared for all that Mother Nature can deliver:


  • January to March: average temp during the day is 64°F and 25°F at night
  • April to June: average temp during the day is 89°F and 41°F at night
  • July to September: average temp during the day is 89°F and 53°F at night
  • October to December: average temp during the day is 75°F and 26°F at night
  • Annual rainfall average: 48.66 inches

Things to See and Do in Cairo


You may want to experience the local activities when you are visiting Cairo. Explore these well-known attractions during your visit:

  • Fort Defiance
  • Ullin City Hall
  • Columbus-Belmont State Park

Recent Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.