Cheap flights from MFE to SAN (Miller Intl. to San Diego Intl.)

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Cheap Flights from MFE to SAN starting at $224 One Way, $346 Round Trip

Prices starting at $346 for return flights and $224 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Nov 18 - Sat, Nov 21
MFE
McAllen
SAN
San Diego
$346 Roundtrip, found 19 hours ago
$346
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Nov 18 from McAllen to San Diego, returning Sat, Nov 21, priced at $346 found 19 hours ago
Sun, Dec 20 - Wed, Jan 6
MFE
McAllen
SAN
San Diego
$350 Roundtrip, found 1 day ago
$350
Roundtrip
found 1 day ago
Select United flight, departing Sun, Dec 20 from McAllen to San Diego, returning Wed, Jan 6, priced at $350 found 1 day ago
Wed, Nov 18 - Sat, Nov 21
MFE
McAllen
SAN
San Diego
$355 Roundtrip, found 19 hours ago
$355
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Nov 18 from McAllen to San Diego, returning Sat, Nov 21, priced at $355 found 19 hours ago
Sun, Dec 20 - Wed, Jan 6
MFE
McAllen
SAN
San Diego
$355 Roundtrip, found 1 day ago
$355
Roundtrip
found 1 day ago
Select United flight, departing Sun, Dec 20 from McAllen to San Diego, returning Wed, Jan 6, priced at $355 found 1 day ago
Sun, Dec 20 - Thu, Jan 7
MFE
McAllen
SAN
San Diego
$359 Roundtrip, found 11 hours ago
$359
Roundtrip
found 11 hours ago
Select United flight, departing Sun, Dec 20 from McAllen to San Diego, returning Thu, Jan 7, priced at $359 found 11 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$183 nightly
The price is $210 total per night from Oct 25 to Oct 26
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (3,721 reviews)
"Staff from check-in to breakfast service were friendly and efficient. Dining area was clean as well as the property. I will definitely come back and recommend to others."

Reviewed on Sep 29, 2026

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Oct 25 to Oct 26
$211 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,316 reviews)
"It was okay, parking could’ve been better"

Reviewed on Sep 29, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$103 nightly
The price is $119 total per night from Sep 30 to Oct 1
$119 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
$85 nightly
The price is $97 total per night from Sep 30 to Oct 1
$97 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Best Western Seven Seas
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$236 nightly
The price is $271 total per night from Oct 30 to Oct 31
$271 total
Oct 30 - Oct 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,906 reviews)
"We stayed for the PIFA event across the street, so it was very convenient. Check in went smooth and Roberto was very helpful in getting our room very close by other family members. One of the staff members gave us a ride to the event, which was a blessing since we walked with our uncle who was elderly ..."

Reviewed on Sep 28, 2026

Paradise Point Resort & Spa
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$103 nightly
The price is $119 total per night from Sep 30 to Oct 1
$119 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Oct 25 to Oct 26
$211 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,316 reviews)
"It was okay, parking could’ve been better"

Reviewed on Sep 29, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$183 nightly
The price is $210 total per night from Oct 25 to Oct 26
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (3,721 reviews)
"Staff from check-in to breakfast service were friendly and efficient. Dining area was clean as well as the property. I will definitely come back and recommend to others."

Reviewed on Sep 29, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$148 nightly
The price is $170 total per night from Oct 27 to Oct 28
$170 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,094 reviews)
"Accueil à l’hôtel peu sympathique en soirée mais le chauffeur de la navette était sympa ainsi que le personnel le lendemain matin au check out. Chambre correctes sans plus. Tout près de l’autoroute donc un peu bruyant."

Reviewed on Sep 25, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$75 nightly
The price is $86 total per night from Oct 4 to Oct 5
$86 total
Oct 4 - Oct 5
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,583 reviews)
"The room was very clean. Location is good, close to freeway and shop, restaurant. Outside look of the hotel is old and not pretty at all. However, the room is big enough and clean. Plenty of Free parking is also a plus. Good value for a stay. Staff is not very friendly, but ok to deal with."

Reviewed on Sep 29, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$71 nightly
The price is $81 total per night from Sep 30 to Oct 1
$81 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$107 nightly
The price is $122 total per night from Oct 29 to Oct 30
$122 total
Oct 29 - Oct 30
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,786 reviews)
"They’re clean every day very good service"

Reviewed on Sep 29, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$227 nightly
The price is $261 total per night from Sep 30 to Oct 1
$261 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly resort in San Diego. Enjoy free parking, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and ...
Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$194 nightly
The price is $223 total per night from Sep 30 to Oct 1
$223 total
Sep 30 - Oct 1
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,442 reviews)
"home away from home"

Reviewed on Sep 29, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$245 nightly
The price is $282 total per night from Oct 28 to Oct 29
$282 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MFE to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Miller Intl. Airport (MFE) to San Diego Airport?
Jetting from MFE to SAN takes at least 4 hours and 54 minutes. Treat yourself to a wine and watch a movie or two — here's your chance to kick back and unwind.
How many hours flight from Miller Intl. Airport (MFE) to San Diego Intl. Airport (SAN)?
Usually, flying from McAllen Miller Intl. Airport to SAN takes 5 hours. If you would like to be as comfortable as you can, consider upgrading your seat using air miles or cash.
What airlines have the most flights from MFE to San Diego Airport?
You'll have to make at least one stopover if you're traveling from MFE to SAN. Right now, there are no airlines that have direct flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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