$311 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, May 1 - Wed, May 13
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$580 Roundtrip, found 1 day ago
$580
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, May 1 from Tocumen Intl. to Las Americas Intl., returning Wed, May 13, priced at $580 found 1 day ago

Airfares from $311 One Way, $474 Round Trip from Panama City to Santo Domingo

Prices starting at $474 for return flights and $311 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jun 14 - Mon, Jun 15
PTY
Panama City
SDQ
Santo Domingo
$474 Roundtrip, found 3 days ago
$474
Roundtrip
found 3 days ago
Select Copa flight, departing Sun, Jun 14 from Panama City to Santo Domingo, returning Mon, Jun 15, priced at $474 found 3 days ago
Sun, Jun 14 - Mon, Jun 15
PTY
Panama City
SDQ
Santo Domingo
$485 Roundtrip, found 3 days ago
$485
Roundtrip
found 3 days ago
Select Copa flight, departing Sun, Jun 14 from Panama City to Santo Domingo, returning Mon, Jun 15, priced at $485 found 3 days ago
Mon, Jun 1 - Fri, Jul 31
PTY
Panama City
SDQ
Santo Domingo
$501 Roundtrip, found 5 days ago
$501
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Jun 1 from Panama City to Santo Domingo, returning Fri, Jul 31, priced at $501 found 5 days ago
Mon, Jun 1 - Fri, Jul 31
PTY
Panama City
SDQ
Santo Domingo
$512 Roundtrip, found 5 days ago
$512
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Jun 1 from Panama City to Santo Domingo, returning Fri, Jul 31, priced at $512 found 5 days ago
Thu, May 14 - Thu, Oct 15
PTY
Panama City
SDQ
Santo Domingo
$529 Roundtrip, found 4 days ago
$529
Roundtrip
found 4 days ago
Select Copa flight, departing Thu, May 14 from Panama City to Santo Domingo, returning Thu, Oct 15, priced at $529 found 4 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Halibut Hotel
3.0-star property

Halibut Hotel

8.6/10 Excellent! (89 reviews)

Jun 2 - Jun 9

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $844, price is now $765 per person
$765
per person
found 22 hours ago
Bahia Principe Escape Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,713 reviews)

Jun 2 - Jun 9

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,017, price is now $1,176 per person
$1,176
per person
found 23 hours ago
Beautiful places with excellent people and great services.

Reviewed on Apr 4, 2026

Bahia Principe Escape Samaná - Adults Only
4.5-star property

Bahia Principe Escape Samaná - Adults Only

8.8/10 Excellent! (667 reviews)

Jun 2 - Jun 9

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,826, price is now $1,098 per person
$1,098
per person
found 23 hours ago
Beautiful hotel, friendly staff, Room had an amazing view of the ocean. The food was far better then expected and alcohol selection was also good. My overall stay was amazing, got the rest i needed. I would definitely recommend the resort to anyone.

Reviewed on Dec 18, 2018

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

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Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.