Hotels in Santee

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Dec 24 - Dec 25
Tonight
Check prices in Santee for tonight, Dec 24 - Dec 25
Dec 25 - Dec 26
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Check prices in Santee for tomorrow night, Dec 25 - Dec 26

Top Rated Santee Hotels

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$105 nightly
The price is $117 total per night
$117 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$75 nightly
The price is $83 total per night
$83 total
Dec 25 - Dec 26
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
0.62 mi from city center
$121 nightly
The price is $134 total per night
$134 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests staying at Fairfield Inn & Suites by Marriott Santee enjoy an outdoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.59 mi from city center
$134 nightly
The price is $149 total per night
$149 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Free Cancellation
Reserve now, pay when you stay
0.17 mi from city center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Free Cancellation
0.17 mi from city center
$104 nightly
The price is $115 total per night
$115 total
Dec 28 - Dec 29
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.
Pool
Pet friendly
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.56 mi from city center
$118 nightly
The price is $131 total per night
$131 total
Dec 30 - Dec 31
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
0.14 mi from city center
$59 nightly
The price is $66 total per night
$66 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Quality Inn & Suites Santee I-95 features free WiFi in public areas, a seasonal outdoor pool, and microwave in a common area. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a refrigerator in a common area, a computer station, and laundry facilities.
Pool
Breakfast included
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.73 mi from city center
$61 nightly
The price is $68 total per night
$68 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Travelodge by Wyndham Santee features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and tours/tickets. Additional amenities include an ATM and a vending machine.
Breakfast included
Pet friendly
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.17 mi from city center
$70 nightly
The price is $78 total per night
$78 total
Dec 25 - Dec 26
Total with taxes and fees
Red Roof Inn Santee features free WiFi in public areas, coffee in a common area, and express check-out. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. This smoke-free hotel also has a vending machine.
Breakfast included
Pet friendly
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
0.45 mi from city center
$80 nightly
The price is $88 total per night
$88 total
Dec 30 - Dec 31
Total with taxes and fees
Guests of Ramada by Wyndham Santee I-95 have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking, and an airport shuttle (available 24 hours) for USD 80 per room roundtrip. The 24-hour front desk has staff always at the ready. Other amenities at this golf hotel include meeting rooms, a conference center, and a 24-hour business center.
Pool
Breakfast included
Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

4 out of 5
401 Bass Drive Santee SC
0.16 mi from city center
Guests staying at Wyndham Vacation Resorts Lake Marion enjoy features like an outdoor pool. Free parking is included with your stay.
Pool
Kitchen
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Santee hotels options

    Baymont by Wyndham Santee

    Baymont by Wyndham Santee

    249 Britain Street Santee SC
    $75 nightly
    The price is $83 total per night from Dec 25 to Dec 26
    $83 total
    Dec 25 - Dec 26
    Total with taxes and fees
    7.8/10 Good! (1,421 reviews)
    Red Roof Inn Santee

    Red Roof Inn Santee

    9091 Old Hwy 6 Santee SC
    $70 nightly
    The price is $78 total per night from Dec 25 to Dec 26
    $78 total
    Dec 25 - Dec 26
    Total with taxes and fees
    6.4/10 (638 reviews)
    Travelodge by Wyndham Santee

    Travelodge by Wyndham Santee

    9117 Old Number Six Hwy Santee SC
    $61 nightly
    The price is $68 total per night from Jan 5 to Jan 6
    $68 total
    Jan 5 - Jan 6, 2026
    Total with taxes and fees
    7/10 Good! (678 reviews)
    Super 8 by Wyndham Santee

    Super 8 by Wyndham Santee

    9125 Old Highway 6 Santee SC
    $75 nightly
    The price is $83 total per night from Dec 25 to Dec 26
    $83 total
    Dec 25 - Dec 26
    Total with taxes and fees
    6.6/10 (441 reviews)
    Econo Lodge

    Econo Lodge

    9112 Old 6 Highway Santee SC
    $63 nightly
    The price is $70 total per night from Jan 7 to Jan 8
    $70 total
    Jan 7 - Jan 8, 2026
    Total with taxes and fees
    6.2/10 (308 reviews)
    Comfort Inn & Suites Santee

    Comfort Inn & Suites Santee

    221 Britain St Santee SC
    $103 nightly
    The price is $114 total per night from Jan 4 to Jan 5
    $114 total
    Jan 4 - Jan 5, 2026
    Total with taxes and fees
    8/10 Very Good! (1,002 reviews)

Where is a good place to stay in Santee?

What are the best family-friendly hotels in Santee?

Check out these hotels for your family's stay in Santee. Fairfield Inn & Suites by Marriott Santee is a hotel offering an outdoor pool, free parking, and free breakfast. You and your family can also consider Comfort Inn & Suites Santee, a hotel offering free parking, free buffet breakfast, and laundry facilities.

What are the best hotels in central Santee?

Here are some of the most popular hotels in the center of Santee:

While you're enjoying local activities like golfing, take some time to check out the restaurants in family-friendly Santee. Close to central Santee, you'll find interesting places to visit like Santee Cooper Country Club.

What are some of the best hotels near Santee State Park?

Get some fresh air at this natural setting, which is 2.7 mi from the heart of Santee. You'll find 20 hotels within 5 miles of Santee State Park, giving you plenty of options to choose from including:

Santee hotels essential information

Accommodation
305 hotels
Lowest Price
$66
Highest Price
$149
Popular hotels
Tru By Hilton Santee, Baymont by Wyndham Santee, Fairfield Inn & Suites by Marriott Santee, Hampton Inn Santee-I-95, Comfort Inn & Suites Santee, Holiday Inn Santee by IHG, Best Western Plus Santee Inn, Quality Inn & Suites, Travelodge by Wyndham Santee, Red Roof Inn Santee, Ramada by Wyndham Santee I-95, Wyndham Vacation Resorts Lake Marion

Recent Reviews

Tru By Hilton Santee

Tru By Hilton Santee

5/5 Excellent
" the rooms are clean. The bed was comfortable. I liked the way they supply shampoo and conditioner and such in each room. Showers were nice and clean plenty of towels. Water pressure was good. Enjoyed our stay. We always try to stay at a true when traveling."
A verified traveler stayed at Tru By Hilton Santee
Posted 3 days ago
Tru By Hilton Santee

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