Business Hotels in Muscatine, IA
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Featured Muscatine Business Hotels

Hampton Inn Muscatine
3303 N Port Drive Muscatine IA
Free Cancellation
Reserve now, pay when you stay
$93 nightly
The price is $105 total per night
$105 total
Dec 30 - Dec 31
Total with taxes and fees
Guests of Hampton Inn Muscatine enjoy a 24-hour gym, free WiFi in public areas, and a business center. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include coffee/tea in a common area, a meeting room, and express check-out.
Breakfast included
Pet friendly

AmericInn by Wyndham Muscatine
3115 Hwy 61 North Muscatine IA
Free Cancellation
Reserve now, pay when you stay
$81 nightly
The price is $90 total per night
$90 total
Dec 30 - Dec 31
Total with taxes and fees
At AmericInn by Wyndham Muscatine, guests have access to an indoor pool, free WiFi in public areas, and a hot tub. If you drive, take advantage of free parking. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. Additional amenities include conference space, a business center, and laundry facilities.
Pool
Hot Tub

Comfort Inn Muscatine near Hwy 61
115 Cleveland St Muscatine IA
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $78 total per night
$78 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
Comfort Inn Muscatine near Hwy 61 features an indoor pool, free WiFi in public areas, and coffee in a common area. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Pool
Breakfast included

Best Western Muscatine / Pearl City Hotel
305 Cleveland St Muscatine IA
Free Cancellation
Reserve now, pay when you stay
$86 nightly
The price is $96 total per night
$96 total
Dec 28 - Dec 29
Total with taxes and fees
At Best Western Muscatine / Pearl City Hotel, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a business center, a microwave in a common area, and express check-out.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Muscatine hotels essential information
Accommodation | 300 hotels |
|---|---|
Lowest Price | $78 |
Highest Price | $105 |
Popular hotels | Hampton Inn Muscatine, AmericInn by Wyndham Muscatine, Comfort Inn Muscatine near Hwy 61, Best Western Muscatine / Pearl City Hotel |
Recent Business Hotels Reviews

Best Western Muscatine / Pearl City Hotel
5/5 Excellent
"Staff was very friendly and helpful. Free soup at night was very good and warming when temps got below 10. Nice touch."
A verified traveler stayed at Best Western Muscatine / Pearl City Hotel
Posted 10 days ago


