Medical Center District Vacation Packages
Book a Stay + Flight or Car to save on your trip
Top Medical Center District vacation package deals
Price found within the past 48 hours. Click for updated prices.
4.5-star property
The St. Anthony, A Luxury Collection Hotel, San Antonio
Downtown San Antonio
8.8/10 Excellent! (1,005 reviews)
Dec 23 - Dec 26
3 night stay
Dallas (DFW) to San Antonio (SAT)
Southwest Airlines • Roundtrip • Coach
Price was $1,056, price is now $803 per person
$803
per person
found 18 hours ago
The St. Anthony is within walking distance of the river walk, Alamo and many other downtown tourist area. Great location, staff and rooms.
Reviewed on Sep 25, 2026
4.0-star property
Hotel Contessa
Downtown San Antonio
9/10 Wonderful! (3,885 reviews)
Nov 15 - Nov 19
4 night stay
Cleveland (CLE) to San Antonio (SAT)
Southwest Airlines • Non-stop • Coach
San Antonio (SAT) to Cleveland (CLE)
American Airlines • Non-stop • Coach
Price was $851, price is now $667 per person
$667
per person
found 1 day ago
3.5-star property
Club Wyndham Riverside Suites
Downtown San Antonio
7.6/10 Good! (94 reviews)
Nov 7 - Nov 10
3 night stay
Newark Liberty Intl. Airport (EWR) to San Antonio (SAT)
United • Roundtrip • Coach
Price was $951, price is now $749 per person
$749
per person
found 9 hours ago
There were shops and food nearby on the riverwalk and elsewhere. Have no idea if the place was pet friendly as I am not a pet owner.
Reviewed on May 7, 2026
Top rated hotels for your Medical Center District vacation package
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Free Cancellation
Reserve now, pay when you stay
1.43 mi from Medical Center District
$89 nightly
The price is $105 total per night
$105 total
Sep 28 - Sep 29
Total with taxes and fees
Guests staying at La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW enjoy an outdoor pool, a gym, and free WiFi in public areas. Self parking is offered for USD 10.00 per stay. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
Free Cancellation
Reserve now, pay when you stay
1.93 mi from Medical Center District
$90 nightly
The price is $106 total per night
$106 total
Oct 1 - Oct 2
Total with taxes and fees
Guests of Drury Inn & Suites San Antonio Northwest Medical Center have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a hot tub, a business center, and coffee/tea in a common area.
Pool
Hot Tub
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
Free Cancellation
Reserve now, pay when you stay
0.92 mi from Medical Center District
$89 nightly
The price is $105 total per night
$105 total
Oct 3 - Oct 4
Total with taxes and fees
At Courtyard by Marriott Medical Center San Antonio, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Pet friendly
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
