Medical Center District Vacation Packages
Book a Stay + Flight or Car to save on your trip
Top Medical Center District vacation package deals
Price found within the past 48 hours. Click for updated prices.
3.5-star property
The O'Brien Riverwalk Hotel, Trademark Collection by Wyndham
Downtown San Antonio
8/10 Very Good! (1,039 reviews)
Dec 16 - Dec 20
4 night stay
Tucson (TUS) to San Antonio (SAT)
United • Non-stop roundtrip • Coach
Price was $788, price is now $621 per person
$621
per person
found 5 hours ago
Clean, peaceful, close to everything
Reviewed on Sep 28, 2026
Top rated hotels for your Medical Center District vacation package
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Free Cancellation
Reserve now, pay when you stay
1.43 mi from Medical Center District
$89 nightly
The price is $105 total per night
$105 total
Sep 30 - Oct 1
Total with taxes and fees
Guests staying at La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW enjoy an outdoor pool, a gym, and free WiFi in public areas. Self parking is offered for USD 10.00 per stay. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
Free Cancellation
Reserve now, pay when you stay
1.93 mi from Medical Center District
$90 nightly
The price is $106 total per night
$106 total
Oct 19 - Oct 20
Total with taxes and fees
Guests of Drury Inn & Suites San Antonio Northwest Medical Center have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a hot tub, a business center, and coffee/tea in a common area.
Pool
Hot Tub
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
Free Cancellation
Reserve now, pay when you stay
0.92 mi from Medical Center District
$98 nightly
The price is $116 total per night
$116 total
Oct 6 - Oct 7
Total with taxes and fees
At Courtyard by Marriott Medical Center San Antonio, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Pet friendly
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
