$23 Cheap flights to Madre de Dios Region

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap flights to Madre de Dios Region from $23 One Way, $45 Round Trip

$45 return flights and $23 one-way flights to Madre de Dios Region were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Mar 7 - Wed, Mar 11
CUZ
Cusco
PEM
Puerto Maldonado
$45 Roundtrip, found 8 hours ago
$45
Roundtrip
found 8 hours ago
Select SKY AIRLINE flight, departing Sat, Mar 7 from Cusco to Puerto Maldonado, returning Wed, Mar 11, priced at $45 found 8 hours ago
Wed, Apr 15 - Thu, Apr 16
CUZ
Cusco
PEM
Puerto Maldonado
$52 Roundtrip, found 13 hours ago
$52
Roundtrip
found 13 hours ago
Select SKY AIRLINE flight, departing Wed, Apr 15 from Cusco to Puerto Maldonado, returning Thu, Apr 16, priced at $52 found 13 hours ago
Sat, Jan 24 - Mon, Jan 26
CUZ
Cusco
PEM
Puerto Maldonado
$53 Roundtrip, found 3 days ago
$53
Roundtrip
found 3 days ago
Select SKY AIRLINE flight, departing Sat, Jan 24 from Cusco to Puerto Maldonado, returning Mon, Jan 26, priced at $53 found 3 days ago
Sun, Jul 26 - Tue, Jul 28
CUZ
Cusco
PEM
Puerto Maldonado
$64 Roundtrip, found 5 days ago
$64
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Sun, Jul 26 from Cusco to Puerto Maldonado, returning Tue, Jul 28, priced at $64 found 5 days ago
Thu, May 21 - Wed, May 27
LIM
Lima
PEM
Puerto Maldonado
$114 Roundtrip, found 3 days ago
$114
Roundtrip
found 3 days ago
Select SKY AIRLINE flight, departing Thu, May 21 from Lima to Puerto Maldonado, returning Wed, May 27, priced at $114 found 3 days ago
Sat, Jan 24 - Mon, Feb 2
AYP
Ayacucho
PEM
Puerto Maldonado
$215 Roundtrip, found 12 hours ago
$215
Roundtrip
found 12 hours ago
Select SKY AIRLINE flight, departing Sat, Jan 24 from Ayacucho to Puerto Maldonado, returning Mon, Feb 2, priced at $215 found 12 hours ago
Sat, Feb 7 - Mon, Feb 16
MIA
Miami
PEM
Puerto Maldonado
$552 Roundtrip, found 11 hours ago
$552
Roundtrip
found 11 hours ago
Select Sky Airline Peru flight, departing Sat, Feb 7 from Miami to Puerto Maldonado, returning Mon, Feb 16, priced at $552 found 11 hours ago
Tue, Nov 3 - Tue, Nov 3
MIA
Miami
PEM
Puerto Maldonado
$709 Roundtrip, found 17 hours ago
$709
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Tue, Nov 3 from Miami to Puerto Maldonado, returning Tue, Nov 3, priced at $709 found 17 hours ago
Mon, Sep 7 - Mon, Sep 7
MIA
Miami
PEM
Puerto Maldonado
$711 Roundtrip, found 17 hours ago
$711
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Mon, Sep 7 from Miami to Puerto Maldonado, returning Mon, Sep 7, priced at $711 found 17 hours ago
Wed, May 13 - Wed, May 13
MIA
Miami
PEM
Puerto Maldonado
$716 Roundtrip, found 17 hours ago
$716
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Wed, May 13 from Miami to Puerto Maldonado, returning Wed, May 13, priced at $716 found 17 hours ago
Tue, Nov 3 - Tue, Nov 3
MIA
Miami
PEM
Puerto Maldonado
$727 Roundtrip, found 17 hours ago
$727
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Tue, Nov 3 from Miami to Puerto Maldonado, returning Tue, Nov 3, priced at $727 found 17 hours ago
Wed, Jun 17 - Wed, Jun 17
MIA
Miami
PEM
Puerto Maldonado
$731 Roundtrip, found 17 hours ago
$731
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Wed, Jun 17 from Miami to Puerto Maldonado, returning Wed, Jun 17, priced at $731 found 17 hours ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
CUZTambopataDecember 21 to December 24$149
LIMTambopataDecember 19 to December 31$271
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Our Top Madre de Dios Region Apartment Hotels

CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

Get rates
Opens in a new windowCHIMICUAS HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Madre de Dios Region Accommodation Deals

Plaza Jungle Hostel

Plaza Jungle Hostel

1 out of 5
229 Arequipa Puerto Maldonado Madre de Dios
Fully refundableReserve now, pay when you stay
$29 nightly
The price is $29 total per night from Dec 16 to Dec 17
$29 total
Dec 16 - Dec 17
Stay at this hostel in Tambopata. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Maldonado Casino and Puerto Maldonado Plaza ...
8/10 Very Good! (1 review)
Atendimento

Reviewed on Nov 28, 2025

Opens in a new windowPlaza Jungle Hostel
IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo Tambopata Madre de Dios
$232 nightly
The price is $232 total per night from Dec 16 to Dec 17
$232 total
Dec 16 - Dec 17
Book a stay at this all-inclusive hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado ...
9.2/10 Wonderful! (8 reviews)
Half an hour a at from Puerto Maldonado by boat , the place is lovely, with river view and a feel of the jungle without venturing too far. We felt like we got a good insight into the area, with included excursions on the river and into the jungle. Our guide Yuri, who was with us throughout, was very ...

Reviewed on Sep 23, 2025

Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Libelula Hotel

Libelula Hotel

2 out of 5
Jr Puno No. 429 Tambopata Madre de Dios
Fully refundableReserve now, pay when you stay
Stay at this hostal in Tambopata. Enjoy free WiFi, daily housekeeping, and cable TV channels. Popular attractions Puerto Maldonado Plaza de Armas and Maldonado ...
9/10 Wonderful! (21 reviews)
Great stay, friendly owners and staff.

Reviewed on Jun 22, 2025

Get rates
Opens in a new windowLibelula Hotel
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Villa Hermosa de Tambopata

Villa Hermosa de Tambopata

2.5 out of 5
Km 0.25 Carretera a Tambopata Tambopata Madre de Dios
Fully refundableReserve now, pay when you stay
$45 nightly
The price is $45 total per night from Dec 16 to Dec 17
$45 total
Dec 16 - Dec 17
Stay at this guesthouse in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado Obelisk are ...
The hotel was very charming, and the staff was great even got to swim in the pool after we finish our Amazon tour

Reviewed on Jun 15, 2024

Opens in a new windowVilla Hermosa de Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Madre de Dios Region

Refugio Amazonas
Great for families

Refugio Amazonas

3 out of 5
Rio Tambopata Tambopata Madre de Dios
$1,669 nightly
The price is $1,669 total per night from Dec 29 to Dec 30
$1,669 total
Dec 29 - Dec 30
Book a stay at this family-friendly inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Condemned ...

Families like: Kids club, playground, babysitting, bicycle rentals

Travelers say...
Our experience was amazing! This was an experience that I have always dreamed about. The guides for the excursions were the best. They were so knowledgeable and friendly. I will never forget all the beautiful sounds that you wake up to in the rainforest. The lodge was very eco friendly and the rooms ...

Reviewed on Apr 4, 2022

Opens in a new windowRefugio Amazonas
Andean Wings Sotupa Eco Lodge
Great for families

Andean Wings Sotupa Eco Lodge

2 out of 5
Carretera Tambopata Km 11,5 Tambopata Madre de Dios
Book a stay at this beach guesthouse in Tambopata. Enjoy free breakfast, free parking, and a free beach shuttle. Popular attractions Puerto Capitanía and Puerto ...
8/10 Very Good! (4 reviews)

Families like: Outdoor pool, game room, close to beach, bicycle rentals

Travelers say...
The property itself is very well built we were surprised we had no issues with bugs inside the room! The view from our room was great also. This was our first time in PM so we didn’t know what to expect, but thought there would be more things to do there for what we paid. We also thought there would ...

Reviewed on Apr 26, 2025

Get rates
Opens in a new window Andean Wings Sotupa Eco Lodge
CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

Get rates
Opens in a new windowCHIMICUAS HOUSE
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Ecolucerna Lodge Tambopata
Great for families

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
10/10 Exceptional! (4 reviews)

Families like: Playground, game room, close to beach, free breakfast for the whole family

Travelers say...
we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing!

Reviewed on Oct 29, 2025

Get rates
Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark or similar
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus or similar
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla or similar
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass or similar
  • 5 people
Jeep Compass
SUV Jeep Compass

Madre de Dios Region

Save money on your flights to Madre de Dios Region as well as on hotel and car packages.

 

Free Fees

Snap up cheap Madre de Dios Region flights at Orbitz, and pay no booking fees. We also don’t charge fees when your plans change or are cancelled. While you’re there, check out our low fare deals on flights to other locations besides flights to Madre de Dios Region.

Everyday Is a Great Day to Save Even More

Get bonus points from Orbitz, the best discount travel planner in the business. Use your Orbitz Visa to take advantage of sales on Madre de Dios Region flights, or pile on points by using it for gas, groceries, and other everyday goods and services. Pack your wallet with even more savings using our cutting-edge suite of mobile tools.

Mix and Match

At Orbitz, we turned a great idea from the world of fashion into another way for you to save money. When you shop our low cost tickets on flights to any destination, don’t be afraid to mix and match different airlines for maximum savings on your Madre de Dios Region flights air ticket. Save more on air travel every day in every way at Orbitz.

Frequently asked questions

How much is a flight to Madre de Dios Region?
Round-trip flights to Madre de Dios Region this last week ranged between $45 and $731. If you were traveling one-way out of Cusco (CUZ), you could have snapped up ticket prices from just $23.
How to book the cheapest flight to Madre de Dios Region?
Scoring cheap flights to Madre de Dios Region is as simple as booking with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips to keep your wallet happy:

  • Depending on where you're departing from, click on the 'Nearby airports' function (located under the departure and arrival form fields). At times, other departure points offer better value for money.
  • Similarly, click on the 'Show flexible dates' option and you'll see the airfares on days around your chosen departure. You may be able to find cheaper flight deals if you're flexible with your dates.
  • You can also select the 'Show options' function to filter results for your preferred airline, seating class, and nonstop and refundable flights. Under 'Sort & Filter' to the left, you can even pick the time of day you'd prefer to fly.
  • The early bird catches the best deals, so book as soon as you've worked out your travel dates. The most affordable fares get snapped up first and prices normally increase as the departure date nears.
  • Make serious savings on your vacation by bundling your hotel, flights and car rentals into an Orbitz package. Your travel budget will thank you.
  • Flying during the busy season can mean higher airfares. Try to avoid traveling over popular periods, such as Easter, Thanksgiving and school breaks.

What is the best time to book a flight to Madre de Dios Region?
Generally speaking, the cheapest time to purchase your airfare is in January. This is closely followed by February and August. When seeking a cheap flight to Madre de Dios Region, it's worth being ready to book. Cheap deals pop up suddenly and don't stick around!
What day of the week is the cheapest to book a flight to Madre de Dios Region?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days to book a flight to Madre de Dios Region. If you want the most competitive airfares, search across those days and you're likely to catch an excellent flight deal.
What is the cheapest day of the week to fly to Madre de Dios Region?
If you're searching for cheap flights to Madre de Dios Region, leave early in the week. Orbitz data from 2020 shows Monday is the cheapest day to travel, followed by Tuesday. Saturday has the most expensive fares, so avoid flying on this day and do your budget a favor.
What is the cheapest month to fly to Madre de Dios Region?
Travel during August if you're on a budget. Orbitz data shows that this is generally the best month for cheap flights to Madre de Dios Region. June is when prices are at their most expensive.
Which airlines allow free cancellation?
When searching for flights on Orbitz, select "Filter by flexible change policies." This filter will show you all the airlines offering free cancellation within 24 hours of booking and no change fees. That means you can relax knowing that if things change, your flight can too.
What do I need for the flight to Madre de Dios Region?
The trick to having a smooth-sailing flight is to be prepared. Here are some tips to take note of before departure:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When booking your flight tickets, we suggest to type in the same name, birth date and gender as written on your government-issued ID.
  • If you're flying directly to Madre de Dios Region, chances are you'll be in the air for quite a while. Pack lots of snacks and things to keep you occupied. Now is the perfect time to get stuck into that novel you've been eyeing off!
  • Cabin temperatures are often cold enough to give you goose pimples. Carry a sweater even if you're traveling during the height of summer.

How do I get cheap first-class/business deals to Madre de Dios Region?
Smart travelers have mastered the art of finding business or first-class airfares to Madre de Dios Region that don't cost a packet. Follow their example with these helpful tips:

  • Flexibility is essential. By being open to a variety of travel dates, you'll have more chances of picking up a deal on business or first-class airfares.
  • A lot of low-cost airlines have terrific business or premium-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's flight rewards program and use points to upgrade your seat. You can also bid for an upgrade in an online auction.

What is the best time to go to Madre de Dios Region?
April, May and August is the most popular time to visit Madre de Dios Region. If you'd like to come when the weather's warmer, purchase your seats for summer. Temperatures typically average around 65 ºF in the evening and 75 ºF during the day at this time of year. Like many places in the Southern Hemisphere, the summer season in Madre de Dios Region begins December 1.
Travel tips for Madre de Dios Region

  • Aguas Calientes Hot Springs is just one of many must-see's while you're visiting Madre de Dios Region. Secure a car rental and enjoy the convenience of exploring this fabulous attraction — and many others — at your convenience.
  • One of Madre de Dios Region's most popular cities, Tambopata is the perfect place to start an epic road trip around this region. Eat, sleep, adventure and repeat — that's what getaways are for!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.