$54 Cheap flights to Madre de Dios Region

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Cheap flights to Madre de Dios Region from $54 One Way, $107 Round Trip

$107 return flights and $54 one-way flights to Madre de Dios Region were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Nov 23 - Fri, Nov 27
CUZ
Cusco
PEM
Puerto Maldonado
$107 Roundtrip, found 14 hours ago
$107
Roundtrip
found 14 hours ago
Select SKY AIRLINE flight, departing Mon, Nov 23 from Cusco to Puerto Maldonado, returning Fri, Nov 27, priced at $107 found 14 hours ago
Sun, Dec 20 - Thu, Dec 24
LIM
Lima
PEM
Puerto Maldonado
$140 Roundtrip, found 4 days ago
$140
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Sun, Dec 20 from Lima to Puerto Maldonado, returning Thu, Dec 24, priced at $140 found 4 days ago
Sun, Jan 24 - Fri, Jan 29
DCA
Washington
PEM
Puerto Maldonado
$582 Roundtrip, found 17 hours ago
$582
Roundtrip
found 17 hours ago
Select LATAM Airlines Group flight, departing Sun, Jan 24 from Washington to Puerto Maldonado, returning Fri, Jan 29, priced at $582 found 17 hours ago
Sat, Apr 10 - Sat, Apr 17
BWI
Baltimore
PEM
Puerto Maldonado
$586 Roundtrip, found 16 hours ago
$586
Roundtrip
found 16 hours ago
Select LATAM Airlines Group flight, departing Sat, Apr 10 from Baltimore to Puerto Maldonado, returning Sat, Apr 17, priced at $586 found 16 hours ago
Thu, Apr 1 - Thu, Apr 8
AUS
Austin
PEM
Puerto Maldonado
$606 Roundtrip, found 8 hours ago
$606
Roundtrip
found 8 hours ago
Select LATAM Airlines Group flight, departing Thu, Apr 1 from Austin to Puerto Maldonado, returning Thu, Apr 8, priced at $606 found 8 hours ago
Thu, Sep 10 - Tue, Sep 15
TPA
Tampa
PEM
Puerto Maldonado
$653 Roundtrip, found 1 day ago
$653
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Thu, Sep 10 from Tampa to Puerto Maldonado, returning Tue, Sep 15, priced at $653 found 1 day ago
Tue, Feb 23 - Sun, Mar 7
MCO
Orlando
PEM
Puerto Maldonado
$661 Roundtrip, found 16 hours ago
$661
Roundtrip
found 16 hours ago
Select LATAM Airlines Group flight, departing Tue, Feb 23 from Orlando to Puerto Maldonado, returning Sun, Mar 7, priced at $661 found 16 hours ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
CUZTambopataAugust 1 to August 7$150
LIMTambopataAugust 2 to August 4$255
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Our Top Madre de Dios Region Apartment Hotels

CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
7.8/10 Good! (7 reviews)
"Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle"

Reviewed on Oct 14, 2016

Get rates
Opens in a new windowCHIMICUAS HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Madre de Dios Region Accommodation Deals

IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo Tambopata Madre de Dios
$213 nightly
The price is $213 total per night from Aug 14 to Aug 15
$213 total
Aug 14 - Aug 15
Stay at this hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado Plaza de Armas ...
9/10 Wonderful! (17 reviews)
"Pros: the grounds were beautiful, comfy bed, AC. Cons: no services nearby, must take a taxi into town to get anywhere. Pricing of meals and activities not inclusive so you pay a lot at check out. There is nowhere else to eat so you have to eat there. The dinners were great, free breakfast was not ..."

Reviewed on Jun 9, 2026

Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Libelula Hotel

Libelula Hotel

2 out of 5
Jr Puno No. 429 Tambopata Madre de Dios
Fully refundableReserve now, pay when you stay
$41 nightly
The price is $41 total per night from Jul 27 to Jul 28
$41 total
Jul 27 - Jul 28
Stay at this hostal in Tambopata. Enjoy free WiFi, daily housekeeping, and cable TV channels. Popular attractions Puerto Maldonado Plaza de Armas and Maldonado ...
8.8/10 Excellent! (31 reviews)
"Good hotel! Recommend to book"

Reviewed on May 14, 2026

Opens in a new windowLibelula Hotel
Posada Amazonas

Posada Amazonas

3 out of 5
Infierno Native Community Tambopata Madre De Dios
$1,087 nightly
The price is $1,087 total per night from Jul 25 to Jul 26
$1,087 total
Jul 25 - Jul 26
Book a stay at this spa inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Collpa Hermosa and ...
9.6/10 Exceptional! (14 reviews)
"Very nice place with excellent guides."

Reviewed on Mar 29, 2026

Opens in a new windowPosada Amazonas
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Ecolucerna Lodge Tambopata

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
$111 nightly
The price is $111 total per night from Jul 30 to Jul 31
$111 total
Jul 30 - Jul 31
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
10/10 Exceptional! (4 reviews)
"we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing!"

Reviewed on Oct 29, 2025

Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Madre de Dios Region

Refugio Amazonas
Great for families

Refugio Amazonas

3 out of 5
Rio Tambopata Tambopata Madre de Dios
$922 nightly
The price is $922 total per night from Aug 14 to Aug 15
$922 total
Aug 14 - Aug 15
Book a stay at this family-friendly inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Condemned ...
8.6/10 Excellent! (25 reviews)

Families like: Kids club, playground, babysitting, bicycle rentals

Travelers say...
"We had an allergy problem. My son is allergic to tree nuts and peanuts. We made the staff and gm aware if it right away. They have all good labeled but had a chicken dish that said chicken and fruit. Come to find out it had Brazil nuts in it. As my son was taking his first bite of chicken ( it was ..."

Reviewed on Jun 3, 2026

Opens in a new windowRefugio Amazonas
Andean Wings Sotupa Eco Lodge
Great for families

Andean Wings Sotupa Eco Lodge

2 out of 5
Carretera Tambopata Km 11,5 Tambopata Madre de Dios
$255 nightly
The price is $255 total per night from Aug 7 to Aug 8
$255 total
Aug 7 - Aug 8
Book a stay at this beach guesthouse in Tambopata. Enjoy free breakfast, free parking, and a free beach shuttle. Popular attractions Puerto Capitanía and Puerto ...
Opens in a new window Andean Wings Sotupa Eco Lodge
CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
7.8/10 Good! (7 reviews)
"Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle"

Reviewed on Oct 14, 2016

Get rates
Opens in a new windowCHIMICUAS HOUSE
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Ecolucerna Lodge Tambopata
Great for families

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
$111 nightly
The price is $111 total per night from Jul 30 to Jul 31
$111 total
Jul 30 - Jul 31
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
10/10 Exceptional! (4 reviews)

Families like: Playground, game room, close to beach, free breakfast for the whole family

Travelers say...
"we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing!"

Reviewed on Oct 29, 2025

Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Madre de Dios Region

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Find Cheap Madre de Dios Region Flights And Hotel Rooms Using Our Mobile App

Orbitz not only guarantees low prices for flights to Madre de Dios Region, we also offer Mobile Steals on our Orbitz on the Go mobile app where you can find great mobile-only deals on hotel rooms in the area.

Use the Orbitz Flight Matrix To Save Big On Car Rental

Discount flights to Madre de Dios Region can be combined with car rental to get you additional savings. Just use our Flight Matrix to see how your budget air ticket can be combined with a car rental to make your trip not only inexpensive but also more convenient.

Use Multiple Airlines To Ensure You Get The Best Deal

Orbitz allows you to use multiple airlines for flights to Madre de Dios Region. By using a combination of airlines for discount flights you are guaranteed to get the lowest fares each way and get the schedule that is most convenient for you.

Store Your Frequent Flyer Information on Orbitz For Easy Access

Booking with Orbitz will still allow you to apply miles for flights to Madre de Dios Region to your frequent flyer program. Not only that, but your frequent flyer information will be safely stored on our website, so it will be easy to access the next time you book a discount air ticket with Orbitz.

Frequently asked questions

How much is a flight to Madre de Dios Region?
Round-trip flights to Madre de Dios Region this last week ranged between $107 and $661. If you were traveling one-way out of Cusco (CUZ), you could have snapped up ticket prices from just $54.
How to book the cheapest flight to Madre de Dios Region?
Scoring cheap flights to Madre de Dios Region is as simple as booking with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips to keep your wallet happy:

  • Depending on where you're departing from, click on the 'Nearby airports' function (located under the departure and arrival form fields). At times, other departure points offer better value for money.
  • Similarly, click on the 'Show flexible dates' option and you'll see the airfares on days around your chosen departure. You may be able to find cheaper flight deals if you're flexible with your dates.
  • You can also select the 'Show options' function to filter results for your preferred airline, seating class, and nonstop and refundable flights. Under 'Sort & Filter' to the left, you can even pick the time of day you'd prefer to fly.
  • The early bird catches the best deals, so book as soon as you've worked out your travel dates. The most affordable fares get snapped up first and prices normally increase as the departure date nears.
  • Make serious savings on your vacation by bundling your hotel, flights and car rentals into an Orbitz package. Your travel budget will thank you.
  • Flying during the busy season can mean higher airfares. Try to avoid traveling over popular periods, such as Easter, Thanksgiving and school breaks.

What is the best time to book a flight to Madre de Dios Region?
Generally speaking, the cheapest time to purchase your airfare is in January. This is closely followed by February and August. When seeking a cheap flight to Madre de Dios Region, it's worth being ready to book. Cheap deals pop up suddenly and don't stick around!
What day of the week is the cheapest to book a flight to Madre de Dios Region?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days to book a flight to Madre de Dios Region. If you want the most competitive airfares, search across those days and you're likely to catch an excellent flight deal.
What is the cheapest day of the week to fly to Madre de Dios Region?
If you're searching for cheap flights to Madre de Dios Region, leave early in the week. Orbitz data from 2020 shows Monday is the cheapest day to travel, followed by Tuesday. Saturday has the most expensive fares, so avoid flying on this day and do your budget a favor.
What is the cheapest month to fly to Madre de Dios Region?
Travel during August if you're on a budget. Orbitz data shows that this is generally the best month for cheap flights to Madre de Dios Region. June is when prices are at their most expensive.
Which airlines allow free cancellation?
When searching for flights on Orbitz, select "Filter by flexible change policies." This filter will show you all the airlines offering free cancellation within 24 hours of booking and no change fees. That means you can relax knowing that if things change, your flight can too.
What do I need for the flight to Madre de Dios Region?
The trick to having a smooth-sailing flight is to be prepared. Here are some tips to take note of before departure:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When booking your flight tickets, we suggest to type in the same name, birth date and gender as written on your government-issued ID.
  • If you're flying directly to Madre de Dios Region, chances are you'll be in the air for quite a while. Pack lots of snacks and things to keep you occupied. Now is the perfect time to get stuck into that novel you've been eyeing off!
  • Cabin temperatures are often cold enough to give you goose pimples. Carry a sweater even if you're traveling during the height of summer.

How do I get cheap first-class/business deals to Madre de Dios Region?
Smart travelers have mastered the art of finding business or first-class airfares to Madre de Dios Region that don't cost a packet. Follow their example with these helpful tips:

  • Flexibility is essential. By being open to a variety of travel dates, you'll have more chances of picking up a deal on business or first-class airfares.
  • A lot of low-cost airlines have terrific business or premium-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's flight rewards program and use points to upgrade your seat. You can also bid for an upgrade in an online auction.

What is the best time to go to Madre de Dios Region?
April, May and August is the most popular time to visit Madre de Dios Region. If you'd like to come when the weather's warmer, purchase your seats for summer. Temperatures typically average around 65 ºF in the evening and 75 ºF during the day at this time of year. Like many places in the Southern Hemisphere, the summer season in Madre de Dios Region begins December 1.
Travel tips for Madre de Dios Region

  • Aguas Calientes Hot Springs is just one of many must-see's while you're visiting Madre de Dios Region. Secure a car rental and enjoy the convenience of exploring this fabulous attraction — and many others — at your convenience.
  • One of Madre de Dios Region's most popular cities, Tambopata is the perfect place to start an epic road trip around this region. Eat, sleep, adventure and repeat — that's what getaways are for!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.