$21 Cheap flights to Madre de Dios Region

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Cheap flights to Madre de Dios Region from $21 One Way, $43 Round Trip

$43 return flights and $21 one-way flights to Madre de Dios Region were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Mar 5 - Wed, Mar 11
CUZ
Cusco
PEM
Puerto Maldonado
$43 Roundtrip, found 5 days ago
$43
Roundtrip
found 5 days ago
Select SKY AIRLINE flight, departing Thu, Mar 5 from Cusco to Puerto Maldonado, returning Wed, Mar 11, priced at $43 found 5 days ago
Wed, May 27 - Fri, May 29
LIM
Lima
PEM
Puerto Maldonado
$102 Roundtrip, found 5 days ago
$102
Roundtrip
found 5 days ago
Select SKY AIRLINE flight, departing Wed, May 27 from Lima to Puerto Maldonado, returning Fri, May 29, priced at $102 found 5 days ago
Fri, Feb 27 - Fri, Mar 6
MIA
Miami
PEM
Puerto Maldonado
$568 Roundtrip, found 3 days ago
$568
Roundtrip
found 3 days ago
Select Sky Airline Peru flight, departing Fri, Feb 27 from Miami to Puerto Maldonado, returning Fri, Mar 6, priced at $568 found 3 days ago
Wed, May 27 - Sun, May 31
AUS
Austin
PEM
Puerto Maldonado
$584 Roundtrip, found 1 day ago
$584
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Wed, May 27 from Austin to Puerto Maldonado, returning Sun, May 31, priced at $584 found 1 day ago
Fri, Nov 13 - Sat, Nov 21
MCO
Orlando
PEM
Puerto Maldonado
$634 Roundtrip, found 5 days ago
$634
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, Nov 13 from Orlando to Puerto Maldonado, returning Sat, Nov 21, priced at $634 found 5 days ago
Fri, Feb 20 - Thu, Mar 5
SFO
San Francisco
PEM
Puerto Maldonado
$694 Roundtrip, found 3 days ago
$694
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, Feb 20 from San Francisco to Puerto Maldonado, returning Thu, Mar 5, priced at $694 found 3 days ago
Sat, Nov 21 - Mon, Nov 30
FLL
Fort Lauderdale
PEM
Puerto Maldonado
$784 Roundtrip, found 1 day ago
$784
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Sat, Nov 21 from Fort Lauderdale to Puerto Maldonado, returning Mon, Nov 30, priced at $784 found 1 day ago
Sat, Feb 7 - Tue, Feb 17
PHL
Philadelphia
PEM
Puerto Maldonado
$936 Roundtrip, found 4 days ago
$936
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Feb 7 from Philadelphia to Puerto Maldonado, returning Tue, Feb 17, priced at $936 found 4 days ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
LIMTambopataJanuary 18 to February 2$199
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Our Top Madre de Dios Region Apartment Hotels

CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

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Opens in a new windowCHIMICUAS HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Madre de Dios Region Accommodation Deals

IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo Tambopata Madre de Dios
$233 nightly
The price is $233 total per night from Feb 9 to Feb 10
$233 total
Feb 9 - Feb 10
Book a stay at this all-inclusive hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado ...
9.2/10 Wonderful! (8 reviews)
Half an hour a at from Puerto Maldonado by boat , the place is lovely, with river view and a feel of the jungle without venturing too far. We felt like we got a good insight into the area, with included excursions on the river and into the jungle. Our guide Yuri, who was with us throughout, was very ...

Reviewed on Sep 23, 2025

Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Plaza Jungle Hostel

Plaza Jungle Hostel

1 out of 5
229 Arequipa Puerto Maldonado Madre de Dios
Fully refundableReserve now, pay when you stay
$29 nightly
The price is $29 total per night from Jan 15 to Jan 16
$29 total
Jan 15 - Jan 16
Stay at this hostel in Tambopata. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Maldonado Casino and Puerto Maldonado Plaza ...
8/10 Very Good! (1 review)
Atendimento

Reviewed on Nov 28, 2025

Opens in a new windowPlaza Jungle Hostel
Inkaterra Reserva Amazonica

Inkaterra Reserva Amazonica

4 out of 5
Madre De Dios River Km. 15 Las Piedras Madre de Dios
Book a stay at this spa hotel in Las Piedras. Enjoy free breakfast, a full-service spa, and a free airport shuttle. Popular attractions Island of Monkeys and ...
9.2/10 Wonderful! (45 reviews)
Rooms were great. Service fantastic and the guide Gus was awesome

Reviewed on Dec 6, 2025

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Opens in a new windowInkaterra Reserva Amazonica
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Villa Hermosa de Tambopata

Villa Hermosa de Tambopata

2.5 out of 5
Km 0.25 Carretera a Tambopata Tambopata Madre de Dios
Fully refundableReserve now, pay when you stay
$45 nightly
The price is $45 total per night from Jan 15 to Jan 16
$45 total
Jan 15 - Jan 16
Stay at this guesthouse in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado Obelisk are ...
9.2/10 Wonderful! (9 reviews)
Amenities. It’s very dirty & cluttered with broken and misc stuff. We ended up booking an alternate accommodation because we were just not comfortable.

Reviewed on Jan 5, 2026

Opens in a new windowVilla Hermosa de Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Madre de Dios Region

Refugio Amazonas
Great for families

Refugio Amazonas

3 out of 5
Rio Tambopata Tambopata Madre de Dios
Book a stay at this family-friendly inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Condemned ...
8.6/10 Excellent! (24 reviews)

Families like: Kids club, playground, babysitting, bicycle rentals

Travelers say...
Our experience was amazing! This was an experience that I have always dreamed about. The guides for the excursions were the best. They were so knowledgeable and friendly. I will never forget all the beautiful sounds that you wake up to in the rainforest. The lodge was very eco friendly and the rooms ...

Reviewed on Apr 4, 2022

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Opens in a new windowRefugio Amazonas
Andean Wings Sotupa Eco Lodge
Great for families

Andean Wings Sotupa Eco Lodge

2 out of 5
Carretera Tambopata Km 11,5 Tambopata Madre de Dios
Book a stay at this beach guesthouse in Tambopata. Enjoy free breakfast, free parking, and a free beach shuttle. Popular attractions Puerto Capitanía and Puerto ...
8/10 Very Good! (4 reviews)

Families like: Outdoor pool, game room, close to beach, bicycle rentals

Travelers say...
The property itself is very well built we were surprised we had no issues with bugs inside the room! The view from our room was great also. This was our first time in PM so we didn’t know what to expect, but thought there would be more things to do there for what we paid. We also thought there would ...

Reviewed on Apr 26, 2025

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Opens in a new window Andean Wings Sotupa Eco Lodge
CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle

Reviewed on Oct 14, 2016

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Opens in a new windowCHIMICUAS HOUSE
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Ecolucerna Lodge Tambopata
Great for families

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
10/10 Exceptional! (4 reviews)

Families like: Playground, game room, close to beach, free breakfast for the whole family

Travelers say...
we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing!

Reviewed on Oct 29, 2025

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Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark or similar
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus or similar
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla or similar
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass or similar
  • 5 people
Jeep Compass
SUV Jeep Compass

Madre de Dios Region

When you plan to buy tickets for flights to Madre de Dios Region, you don’t have to look any further than Orbitz! We offer bargain rates and low fares on thousands of flights.

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Along with our low prices, Orbitz is well known for exceptional customer care. We make it simple to find the best Madre de Dios Region flights for you. If you need to cancel your booking or change your flight plans, simply contact our Customer Service department to make any adjustments.

Bargain Tickets for Madre de Dios Region Flights

Orbitz offers deeply discounted flights to Madre de Dios Region, and we provide the resources to research your travel destination and plan your complete itinerary.

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Frequently asked questions

How much is a flight to Madre de Dios Region?
Round-trip flights to Madre de Dios Region this last week ranged between $43 and $936. If you were traveling one-way out of Cusco (CUZ), you could have snapped up ticket prices from just $21.
How to book the cheapest flight to Madre de Dios Region?
Scoring cheap flights to Madre de Dios Region is as simple as booking with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips to keep your wallet happy:

  • Depending on where you're departing from, click on the 'Nearby airports' function (located under the departure and arrival form fields). At times, other departure points offer better value for money.
  • Similarly, click on the 'Show flexible dates' option and you'll see the airfares on days around your chosen departure. You may be able to find cheaper flight deals if you're flexible with your dates.
  • You can also select the 'Show options' function to filter results for your preferred airline, seating class, and nonstop and refundable flights. Under 'Sort & Filter' to the left, you can even pick the time of day you'd prefer to fly.
  • The early bird catches the best deals, so book as soon as you've worked out your travel dates. The most affordable fares get snapped up first and prices normally increase as the departure date nears.
  • Make serious savings on your vacation by bundling your hotel, flights and car rentals into an Orbitz package. Your travel budget will thank you.
  • Flying during the busy season can mean higher airfares. Try to avoid traveling over popular periods, such as Easter, Thanksgiving and school breaks.

What is the best time to book a flight to Madre de Dios Region?
Generally speaking, the cheapest time to purchase your airfare is in January. This is closely followed by February and August. When seeking a cheap flight to Madre de Dios Region, it's worth being ready to book. Cheap deals pop up suddenly and don't stick around!
What day of the week is the cheapest to book a flight to Madre de Dios Region?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days to book a flight to Madre de Dios Region. If you want the most competitive airfares, search across those days and you're likely to catch an excellent flight deal.
What is the cheapest day of the week to fly to Madre de Dios Region?
If you're searching for cheap flights to Madre de Dios Region, leave early in the week. Orbitz data from 2020 shows Monday is the cheapest day to travel, followed by Tuesday. Saturday has the most expensive fares, so avoid flying on this day and do your budget a favor.
What is the cheapest month to fly to Madre de Dios Region?
Travel during August if you're on a budget. Orbitz data shows that this is generally the best month for cheap flights to Madre de Dios Region. June is when prices are at their most expensive.
Which airlines allow free cancellation?
When searching for flights on Orbitz, select "Filter by flexible change policies." This filter will show you all the airlines offering free cancellation within 24 hours of booking and no change fees. That means you can relax knowing that if things change, your flight can too.
What do I need for the flight to Madre de Dios Region?
The trick to having a smooth-sailing flight is to be prepared. Here are some tips to take note of before departure:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When booking your flight tickets, we suggest to type in the same name, birth date and gender as written on your government-issued ID.
  • If you're flying directly to Madre de Dios Region, chances are you'll be in the air for quite a while. Pack lots of snacks and things to keep you occupied. Now is the perfect time to get stuck into that novel you've been eyeing off!
  • Cabin temperatures are often cold enough to give you goose pimples. Carry a sweater even if you're traveling during the height of summer.

How do I get cheap first-class/business deals to Madre de Dios Region?
Smart travelers have mastered the art of finding business or first-class airfares to Madre de Dios Region that don't cost a packet. Follow their example with these helpful tips:

  • Flexibility is essential. By being open to a variety of travel dates, you'll have more chances of picking up a deal on business or first-class airfares.
  • A lot of low-cost airlines have terrific business or premium-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's flight rewards program and use points to upgrade your seat. You can also bid for an upgrade in an online auction.

What is the best time to go to Madre de Dios Region?
April, May and August is the most popular time to visit Madre de Dios Region. If you'd like to come when the weather's warmer, purchase your seats for summer. Temperatures typically average around 65 ºF in the evening and 75 ºF during the day at this time of year. Like many places in the Southern Hemisphere, the summer season in Madre de Dios Region begins December 1.
Travel tips for Madre de Dios Region

  • Aguas Calientes Hot Springs is just one of many must-see's while you're visiting Madre de Dios Region. Secure a car rental and enjoy the convenience of exploring this fabulous attraction — and many others — at your convenience.
  • One of Madre de Dios Region's most popular cities, Tambopata is the perfect place to start an epic road trip around this region. Eat, sleep, adventure and repeat — that's what getaways are for!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.