$45 Cheap flights to Madre de Dios Region

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Cheap flights to Madre de Dios Region from $45 One Way, $90 Round Trip

$90 return flights and $45 one-way flights to Madre de Dios Region were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Nov 26 - Wed, Dec 2
CUZ
Cusco
PEM
Puerto Maldonado
$90 Roundtrip, found 16 hours ago
$90
Roundtrip
found 16 hours ago
Select SKY AIRLINE flight, departing Thu, Nov 26 from Cusco to Puerto Maldonado, returning Wed, Dec 2, priced at $90 found 16 hours ago
Thu, Dec 3 - Wed, Dec 9
CUZ
Cusco
PEM
Puerto Maldonado
$109 Roundtrip, found 3 days ago
$109
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 3 from Cusco to Puerto Maldonado, returning Wed, Dec 9, priced at $109 found 3 days ago
Fri, Sep 18 - Sat, Sep 26
CUZ
Cusco
PEM
Puerto Maldonado
$111 Roundtrip, found 4 hours ago
$111
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Fri, Sep 18 from Cusco to Puerto Maldonado, returning Sat, Sep 26, priced at $111 found 4 hours ago
Tue, Apr 6 - Thu, Apr 8
CUZ
Cusco
PEM
Puerto Maldonado
$114 Roundtrip, found 6 days ago
$114
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Tue, Apr 6 from Cusco to Puerto Maldonado, returning Thu, Apr 8, priced at $114 found 6 days ago
Mon, May 24 - Fri, May 28
CUZ
Cusco
PEM
Puerto Maldonado
$116 Roundtrip, found 6 hours ago
$116
Roundtrip
found 6 hours ago
Select SKY AIRLINE flight, departing Mon, May 24 from Cusco to Puerto Maldonado, returning Fri, May 28, priced at $116 found 6 hours ago
Mon, May 24 - Fri, May 28
CUZ
Cusco
PEM
Puerto Maldonado
$121 Roundtrip, found 6 hours ago
$121
Roundtrip
found 6 hours ago
Select SKY AIRLINE flight, departing Mon, May 24 from Cusco to Puerto Maldonado, returning Fri, May 28, priced at $121 found 6 hours ago
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Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
LIMTambopataSeptember 11 to September 20$197
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Our Top Madre de Dios Region Apartment Hotels

CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
7.8/10 Good! (7 reviews)
"Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle"

Reviewed on Oct 14, 2016

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Opens in a new windowCHIMICUAS HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Madre de Dios Region Accommodation Deals

Inkaterra Reserva Amazonica

Inkaterra Reserva Amazonica

4 out of 5
Madre De Dios River Km. 15 Las Piedras Madre de Dios
Book a stay at this spa hotel in Las Piedras. Enjoy free breakfast, a full-service spa, and a free airport shuttle. Popular attractions Island of Monkeys and ...
9.4/10 Exceptional! (54 reviews)
"Only remark is to enable electricity in the rooms during the day without interruption for fan and charging phones (solar panel with batteries for example). It was very hot and hard to rest in the room"

Reviewed on Jul 19, 2026

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Opens in a new windowInkaterra Reserva Amazonica
IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo Tambopata Madre de Dios
$188 nightly
The price is $188 total per night from Oct 5 to Oct 6
$188 total
Oct 5 - Oct 6
Stay at this hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado Plaza de Armas ...
Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Libelula Hotel

Libelula Hotel

2 out of 5
Jr Puno No. 429 Tambopata Madre de Dios
Fully refundableReserve now, pay when you stay
$41 nightly
The price is $41 total per night from Sep 5 to Sep 6
$41 total
Sep 5 - Sep 6
Stay at this hostal in Tambopata. Enjoy free WiFi, daily housekeeping, and cable TV channels. Popular attractions Puerto Maldonado Plaza de Armas and Maldonado ...
Opens in a new windowLibelula Hotel
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Ecolucerna Lodge Tambopata

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
$110 nightly
The price is $110 total per night from Sep 8 to Sep 9
$110 total
Sep 8 - Sep 9
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Madre de Dios Region

Refugio Amazonas
Great for families

Refugio Amazonas

3 out of 5
Rio Tambopata Tambopata Madre de Dios
$1,166 nightly
The price is $1,166 total per night from Sep 6 to Sep 7
$1,166 total
Sep 6 - Sep 7
Book a stay at this family-friendly inn in Tambopata. Enjoy a free airport shuttle, onsite spa services, and a 24-hour front desk. Popular attractions Condemned ...
8.6/10 Excellent! (25 reviews)

Families like: Kids club, playground, babysitting, bicycle rentals

Travelers say...
"We had an allergy problem. My son is allergic to tree nuts and peanuts. We made the staff and gm aware if it right away. They have all good labeled but had a chicken dish that said chicken and fruit. Come to find out it had Brazil nuts in it. As my son was taking his first bite of chicken ( it was ..."

Reviewed on Jun 3, 2026

Opens in a new windowRefugio Amazonas
Andean Wings Sotupa Eco Lodge
Great for families

Andean Wings Sotupa Eco Lodge

2 out of 5
Carretera Tambopata Km 11,5 Tambopata Madre de Dios
$182 nightly
The price is $182 total per night from Sep 26 to Sep 27
$182 total
Sep 26 - Sep 27
Book a stay at this beach guesthouse in Tambopata. Enjoy free breakfast, free parking, and a free beach shuttle. Popular attractions Puerto Capitanía and Puerto ...
Opens in a new window Andean Wings Sotupa Eco Lodge
CHIMICUAS HOUSE

CHIMICUAS HOUSE

3.5 out of 5
Jr. Atahuallpa cdra 8 Con Jr. Tambopata Madre de Dios
Book a stay at this business-friendly hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Maldonado Obelisk and ...
7.8/10 Good! (7 reviews)
"Very pleasant welcome to the city. Hospitable and very friendly.great place to come to after or before going to the jungle"

Reviewed on Oct 14, 2016

Get rates
Opens in a new windowCHIMICUAS HOUSE
Save an average of 15% on thousands of hotels when you're signed in
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Ecolucerna Lodge Tambopata
Great for families

Ecolucerna Lodge Tambopata

2.5 out of 5
Rio Madre de Dios, Tambopata Tambopata Madre de Dios
$110 nightly
The price is $110 total per night from Sep 8 to Sep 9
$110 total
Sep 8 - Sep 9
Book a stay at this beach lodge in Tambopata. Enjoy free breakfast, room service, and an airport shuttle (surcharge).
Opens in a new windowEcolucerna Lodge Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Madre de Dios Region

Why search for low cost fares on your flights to Madre de Dios Region when Orbitz offers the guaranteed lowest prices on foreign and domestic flights? When you travel with Orbitz you can benefit from:

Bargain Flights to Madre de Dios Region

Orbitz offers massive discounts and substantial last-minute savings on your Madre de Dios Region flights. Orbitz ensures that you can find, plan and reserve your flights any destination with ease, all while enjoying the guaranteed lowest prices available anywhere.

Cutting-Edge Mobile Tools to Keep You In The Know

Orbitz sends you free alerts and updates on your Madre de Dios Region flight wherever you are in the world. Once you have downloaded the free app for your iPhone, Android, or iPad, you can review or alter any travel plans that you have made or even book a future flight for business or pleasure. If you need to reserve a hotel room when booking your flight, you will find exclusive deals on our mobile site.

Frequent Flyer Program Enrolment

Orbitz finds you the lowest fares, but you can still add your miles to your frequent flyer program to earn miles or points on selected flights to Madre de Dios Region. When making your booking, reference your frequent flyer number to receive discounts in the future.

Outstanding Customer Service

Orbitz values your business and wants to ensure that all of your flights are as easy as possible to book. If you have booked a flight to Madre de Dios Region but need to cancel it, you may be able to do so online. If you have any questions or need help, the dedicated Orbitz customer service team is always standing by.

Frequently asked questions

How much is a flight to Madre de Dios Region?
Round-trip flights to Madre de Dios Region this last week ranged between $90 and $197. If you were traveling one-way out of Cusco (CUZ), you could have snapped up ticket prices from just $45.
How to book the cheapest flight to Madre de Dios Region?
Scoring cheap flights to Madre de Dios Region is as simple as booking with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips to keep your wallet happy:

  • Depending on where you're departing from, click on the 'Nearby airports' function (located under the departure and arrival form fields). At times, other departure points offer better value for money.
  • Similarly, click on the 'Show flexible dates' option and you'll see the airfares on days around your chosen departure. You may be able to find cheaper flight deals if you're flexible with your dates.
  • You can also select the 'Show options' function to filter results for your preferred airline, seating class, and nonstop and refundable flights. Under 'Sort & Filter' to the left, you can even pick the time of day you'd prefer to fly.
  • The early bird catches the best deals, so book as soon as you've worked out your travel dates. The most affordable fares get snapped up first and prices normally increase as the departure date nears.
  • Make serious savings on your vacation by bundling your hotel, flights and car rentals into an Orbitz package. Your travel budget will thank you.
  • Flying during the busy season can mean higher airfares. Try to avoid traveling over popular periods, such as Easter, Thanksgiving and school breaks.

What is the best time to book a flight to Madre de Dios Region?
Generally speaking, the cheapest time to purchase your airfare is in January. This is closely followed by February and August. When seeking a cheap flight to Madre de Dios Region, it's worth being ready to book. Cheap deals pop up suddenly and don't stick around!
What day of the week is the cheapest to book a flight to Madre de Dios Region?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days to book a flight to Madre de Dios Region. If you want the most competitive airfares, search across those days and you're likely to catch an excellent flight deal.
What is the cheapest day of the week to fly to Madre de Dios Region?
If you're searching for cheap flights to Madre de Dios Region, leave early in the week. Orbitz data from 2020 shows Monday is the cheapest day to travel, followed by Tuesday. Saturday has the most expensive fares, so avoid flying on this day and do your budget a favor.
What is the cheapest month to fly to Madre de Dios Region?
Travel during August if you're on a budget. Orbitz data shows that this is generally the best month for cheap flights to Madre de Dios Region. June is when prices are at their most expensive.
Which airlines allow free cancellation?
When searching for flights on Orbitz, select "Filter by flexible change policies." This filter will show you all the airlines offering free cancellation within 24 hours of booking and no change fees. That means you can relax knowing that if things change, your flight can too.
What do I need for the flight to Madre de Dios Region?
The trick to having a smooth-sailing flight is to be prepared. Here are some tips to take note of before departure:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When booking your flight tickets, we suggest to type in the same name, birth date and gender as written on your government-issued ID.
  • If you're flying directly to Madre de Dios Region, chances are you'll be in the air for quite a while. Pack lots of snacks and things to keep you occupied. Now is the perfect time to get stuck into that novel you've been eyeing off!
  • Cabin temperatures are often cold enough to give you goose pimples. Carry a sweater even if you're traveling during the height of summer.

How do I get cheap first-class/business deals to Madre de Dios Region?
Smart travelers have mastered the art of finding business or first-class airfares to Madre de Dios Region that don't cost a packet. Follow their example with these helpful tips:

  • Flexibility is essential. By being open to a variety of travel dates, you'll have more chances of picking up a deal on business or first-class airfares.
  • A lot of low-cost airlines have terrific business or premium-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's flight rewards program and use points to upgrade your seat. You can also bid for an upgrade in an online auction.

What is the best time to go to Madre de Dios Region?
April, May and August is the most popular time to visit Madre de Dios Region. If you'd like to come when the weather's warmer, purchase your seats for summer. Temperatures typically average around 65 ºF in the evening and 75 ºF during the day at this time of year. Like many places in the Southern Hemisphere, the summer season in Madre de Dios Region begins December 1.
Travel tips for Madre de Dios Region

  • Aguas Calientes Hot Springs is just one of many must-see's while you're visiting Madre de Dios Region. Secure a car rental and enjoy the convenience of exploring this fabulous attraction — and many others — at your convenience.
  • One of Madre de Dios Region's most popular cities, Tambopata is the perfect place to start an epic road trip around this region. Eat, sleep, adventure and repeat — that's what getaways are for!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.