$128 Cheap flight deals from Des Moines (DSM) to San Ysidro (SAN)

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This Weekend's Flight Deals from Des Moines to San Ysidro

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 11 - Mon, Sep 14
DSM
Des Moines Intl.
SAN
San Diego Intl.
$365 Roundtrip, found 16 hours ago
$365
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Fri, Sep 11 from Des Moines Intl. to San Diego Intl., returning Mon, Sep 14, priced at $365 found 16 hours ago
Fri, Sep 11 - Sun, Sep 13
DSM
Des Moines Intl.
CLD
McClellan-Palomar
$545 Roundtrip, found 4 hours ago
$545
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Sep 11 from Des Moines Intl. to McClellan-Palomar, returning Sun, Sep 13, priced at $545 found 4 hours ago

Airfares from $128 One Way, $264 Round Trip from Des Moines to San Ysidro

Prices starting at $264 for return flights and $128 for one-way flights to San Ysidro were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Oct 5 - Mon, Oct 12
DSM
Des Moines
SAN
San Diego
$264 Roundtrip, found 4 days ago
$264
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Oct 5 from Des Moines to San Diego, returning Mon, Oct 12, priced at $264 found 4 days ago
Mon, Oct 12 - Fri, Oct 23
DSM
Des Moines
SAN
San Diego
$271 Roundtrip, found 1 hour ago
$271
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, Oct 12 from Des Moines to San Diego, returning Fri, Oct 23, priced at $271 found 1 hour ago
Fri, Oct 23 - Mon, Oct 26
DSM
Des Moines
SAN
San Diego
$275 Roundtrip, just found
$275
Roundtrip
just found
Select Frontier Airlines flight, departing Fri, Oct 23 from Des Moines to San Diego, returning Mon, Oct 26, priced at $275 just found
Mon, Oct 5 - Mon, Oct 12
DSM
Des Moines
SAN
San Diego
$279 Roundtrip, found 4 days ago
$279
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Oct 5 from Des Moines to San Diego, returning Mon, Oct 12, priced at $279 found 4 days ago
Fri, Nov 6 - Mon, Nov 9
DSM
Des Moines
SAN
San Diego
$280 Roundtrip, found 4 days ago
$280
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, Nov 6 from Des Moines to San Diego, returning Mon, Nov 9, priced at $280 found 4 days ago

San Ysidro economy flight packages

Price found within the past 48 hours. Click for updated prices.
Porto Vista Hotel Downtown
3.5-star property

Porto Vista Hotel Downtown

7.4/10 Good! (1,368 reviews)

Oct 14 - Oct 18

4 night stay

Des Moines (DSM) to San Diego (SAN)

American Airlines • Non-stop roundtrip • Coach
Price was $917, price is now $680 per person
$680
per person
found 1 day ago
The best part of the trip was the staff… They were amazing… Yet our room was actually super inconvenient… Shower door would not close at all… Air-conditioning was middle to low average… And there were stains all over the rental from the previous tenants

Reviewed on Sep 9, 2026

Shore House at The Del, LXR Hotels & Resorts
5.0-star property

Shore House at The Del, LXR Hotels & Resorts

9.2/10 Wonderful! (175 reviews)

Oct 14 - Oct 18

4 night stay

Des Moines (DSM) to San Diego (SAN)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $3,108, price is now $2,127 per person
$2,127
per person
found 1 day ago

Margaritaville Hotel San Diego Gaslamp Quarter
4.0-star property

Margaritaville Hotel San Diego Gaslamp Quarter

9/10 Wonderful! (1,523 reviews)

Oct 13 - Oct 16

3 night stay

Des Moines (DSM) to San Diego (SAN)

Southwest Airlines • Non-stop • Coach

San Diego (SAN) to Des Moines (DSM)

Frontier Airlines • Non-stop • Coach
Price was $1,103, price is now $809 per person
$809
per person
found 5 hours ago
The room was super clean and spacious, air conditioning worked very well & the staff were knowledgeable, the roof top bar was a great place for Happy Hour. The breakfast has a good selection and the food was amazing. Everything was within walking distance so that was a real bonus. We would have enjoyed our stay quite a bit more if we didn’t hear our neighbour snoring very loudly for 5 night in a row. Doesn’t appear that the walls are very well insulated at all noise from the hall way was also a factor, the hotel door to the hallway had a gap so not very sound proof. Overall nice hotel just a few things that possibly could use some attention.

Reviewed on Sep 9, 2026

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More About Flying To San Ysidro from Des Moines

Route Information for Flights from Des Moines to San Ysidro

Origin Airport IATA Code
DSM
Destination Airport IATA Code
SAN
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Des Moines to San Ysidro

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.