Cheap flights from MYR to SOU (Myrtle Beach Intl. to Southampton)

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Cheap Flights from MYR to SOU starting at One Way, $1,304 Round Trip

Prices starting at $1,304 for return flights and for one-way flights to Southampton were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$1,304 Roundtrip, found 6 days ago
$1,304
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $1,304 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$1,331 Roundtrip, found 6 days ago
$1,331
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $1,331 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$1,598 Roundtrip, found 6 days ago
$1,598
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $1,598 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$1,732 Roundtrip, found 6 days ago
$1,732
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $1,732 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$1,870 Roundtrip, found 6 days ago
$1,870
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $1,870 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$2,087 Roundtrip, found 6 days ago
$2,087
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $2,087 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$2,094 Roundtrip, found 6 days ago
$2,094
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $2,094 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$2,114 Roundtrip, found 6 days ago
$2,114
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $2,114 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$2,121 Roundtrip, found 6 days ago
$2,121
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $2,121 found 6 days ago
Thu, May 21 - Sun, May 24
MYR
Myrtle Beach
SOU
Southampton
$2,347 Roundtrip, found 6 days ago
$2,347
Roundtrip
found 6 days ago
Select Virgin Atlantic flight, departing Thu, May 21 from Myrtle Beach to Southampton, returning Sun, May 24, priced at $2,347 found 6 days ago

Hotel Ideas near Southampton

Airport Hotels near Southampton

Village Hotel Southampton Eastleigh

Village Hotel Southampton Eastleigh

4 out of 5
Bournemouth Road Eastleigh England
$74 nightly
The price is $89 total per night from Apr 19 to Apr 20
$89 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Eastleigh. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff and ...
8.4/10 Very Good! (885 reviews)
Room was clean and tidy, staff were very friendly and the breakfast was great. Only downside was having a glass bathroom door which we didn’t like

Reviewed on Apr 5, 2026

Village Hotel Southampton Eastleigh
Premier Inn Southampton Airport

Premier Inn Southampton Airport

3 out of 5
Mitchell Way Southampton England
$57 nightly
The price is $69 total per night from Apr 12 to Apr 13
$69 total
Apr 12 - Apr 13
Total with taxes and fees
Stay at this hotel in Southampton. Enjoy breakfast (surcharge), parking (surcharge), and a 24-hour front desk. Popular attractions Southampton Cruise Terminal ...
7.8/10 Good! (16 reviews)
Place is basic and ok. Shower is fine (not great) and bathroom generally is plastic and very basic. This is a very basic airport hotel, overpriced for what it is.

Reviewed on Apr 3, 2026

Premier Inn Southampton Airport
Leonardo Hotel Southampton

Leonardo Hotel Southampton

4 out of 5
1 Charlotte Place Southampton England
$61 nightly
The price is $74 total per night from Apr 12 to Apr 13
$74 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,275 reviews)
Perfect

Reviewed on Apr 3, 2026

Leonardo Hotel Southampton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Southampton

Leonardo Hotel Southampton

Leonardo Hotel Southampton

4 out of 5
1 Charlotte Place Southampton England
$61 nightly
The price is $74 total per night from Apr 12 to Apr 13
$74 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,275 reviews)
Perfect

Reviewed on Apr 3, 2026

Leonardo Hotel Southampton
Leonardo Royal Southampton Grand Harbour

Leonardo Royal Southampton Grand Harbour

4 out of 5
West Quay Road Southampton England
$84 nightly
The price is $101 total per night from Apr 26 to Apr 27
$101 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this spa hotel in Southampton. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.6/10 Excellent! (1,778 reviews)
Overall good experience. Room interior was good. But it was a king superior which while the room was a good space when you opened the window we looked directly at a restaurant vent (assume) and the other window beside it was a bird crap covered structure that had about t years of dirt on it. I'm ...

Reviewed on Apr 5, 2026

Leonardo Royal Southampton Grand Harbour
Moxy Southampton

Moxy Southampton

3 out of 5
Harbour Parade Southampton England
$67 nightly
The price is $81 total per night from Apr 12 to Apr 13
$81 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
9/10 Wonderful! (1,002 reviews)
Friendly staff in this hotel is in a great location. No disappointments here.

Reviewed on Mar 30, 2026

Moxy Southampton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Southampton Hotels

ibis budget Southampton Centre

ibis budget Southampton Centre

2.5 out of 5
West Quay Road Southampton England
$43 nightly
The price is $52 total per night from May 4 to May 5
$52 total
May 4 - May 5
Total with taxes and fees
Stay at this hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff and the clean rooms in ...
7.6/10 Good! (1,033 reviews)
On arrival we were allocated a room and the tv didn’t work. The guy on reception moved us to room 103 and we had no pillows and the bed stunk. There was a hole in the back of the door and the decor through out the hotel was poor. My wife slept in her clothing as it felt like there were bugs in the ...

Reviewed on Apr 5, 2026

ibis budget Southampton Centre
The Star Hotel

The Star Hotel

3 out of 5
26 High Street Southampton England
$50 nightly
The price is $60 total per night from May 4 to May 5
$60 total
May 4 - May 5
Total with taxes and fees
Stay at this hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the breakfast and the helpful staff in ...
7.8/10 Good! (1,000 reviews)
We came back to The Star as we stayed here 18 months ago. You simply can’t beat their location. Pubs, restaurants, shopping, old Southampton and its heritage building. And the history of the Titanic.

Reviewed on Mar 31, 2026

The Star Hotel
Days Inn by Wyndham Southampton Rownhams

Days Inn by Wyndham Southampton Rownhams

3 out of 5
Rownhams Motorway Service Area Southampton England
$45 nightly
The price is $53 total per night from May 4 to May 5
$53 total
May 4 - May 5
Total with taxes and fees
Stay at this hotel in Southampton. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (999 reviews)
Clean room and friendly staff ..services nearby but not many open till late

Reviewed on Mar 31, 2026

Days Inn by Wyndham Southampton Rownhams
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southampton

Holiday Inn Express Southampton M27 Jct7 by IHG

Holiday Inn Express Southampton M27 Jct7 by IHG

3 out of 5
Botley Road Southampton England
$66 nightly
The price is $79 total per night from Apr 26 to Apr 27
$79 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the ...
8.6/10 Excellent! (1,366 reviews)
A pretty average stay sadly made below standard by a rude check in

Reviewed on Apr 4, 2026

Holiday Inn Express Southampton M27 Jct7 by IHG
Novotel Southampton

Novotel Southampton

4 out of 5
1 West Quay Road Southampton England
$58 nightly
The price is $70 total per night from Apr 12 to Apr 13
$70 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,000 reviews)
Our room was clean and well prepared. The full english breakfast was excellent with plenty of choice, and the bar was well attended in a very pleasant ambience. All the staff were very pleasant helpful and professional, you couldn't ask for better.

Reviewed on Apr 1, 2026

Novotel Southampton
DoubleTree by Hilton Southampton

DoubleTree by Hilton Southampton

4 out of 5
Bracken Place, Chilworth Southampton England
$65 nightly
The price is $79 total per night from Apr 12 to Apr 13
$79 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Southampton. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (534 reviews)
Great hotel

Reviewed on Mar 30, 2026

DoubleTree by Hilton Southampton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MYR to SOU Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MYR Address & GPS
Address:
1100 Jetport Road
Myrtle Beach SC, 29577
United States
IATA Code:
MYR
Longitude:
-78.922944
Latitude:
33.682676
Time Zone:
America/New_York
SOU Address & GPS
Address:
Southampton EN,
United Kingdom
IATA Code:
SOU
Longitude:
-1.361318
Latitude:
50.950725
Time Zone:
Europe/London

Frequently asked questions

What airlines have the most flights from Myrtle Beach Intl. Airport (MYR) to SOU?
Unfortunately, you can't fly nonstop from MYR to SOU. However, you will be able to lock in a flight with one or more stops. Look on the bright side — use the time to get the blood moving again or do a little souvenir shopping!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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