$72 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Mayagüez to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 23 - Tue, May 26
SJU
Luis Munoz Marin Intl.
SDQ
Las Americas Intl.
$372 Roundtrip, found 1 hour ago
$372
Roundtrip
found 1 hour ago
Select Copa flight, departing Sat, May 23 from Luis Munoz Marin Intl. to Las Americas Intl., returning Tue, May 26, priced at $372 found 1 hour ago

Airfares from $72 One Way, $161 Round Trip from Mayagüez to Santo Domingo

Prices starting at $161 for return flights and $72 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Aug 10 - Sat, Aug 15
SJU
San Juan
SDQ
Santo Domingo
$161 Roundtrip, found 2 days ago
$161
Roundtrip
found 2 days ago
Select Arajet flight, departing Mon, Aug 10 from San Juan to Santo Domingo, returning Sat, Aug 15, priced at $161 found 2 days ago
Mon, Sep 7 - Mon, Sep 14
SJU
San Juan
SDQ
Santo Domingo
$167 Roundtrip, found 2 days ago
$167
Roundtrip
found 2 days ago
Select Arajet flight, departing Mon, Sep 7 from San Juan to Santo Domingo, returning Mon, Sep 14, priced at $167 found 2 days ago
Sat, Oct 31 - Sat, Nov 7
SJU
San Juan
SDQ
Santo Domingo
$169 Roundtrip, found 2 days ago
$169
Roundtrip
found 2 days ago
Select Arajet flight, departing Sat, Oct 31 from San Juan to Santo Domingo, returning Sat, Nov 7, priced at $169 found 2 days ago
Sat, Sep 12 - Mon, Sep 14
SJU
San Juan
SDQ
Santo Domingo
$171 Roundtrip, found 3 days ago
$171
Roundtrip
found 3 days ago
Select Arajet flight, departing Sat, Sep 12 from San Juan to Santo Domingo, returning Mon, Sep 14, priced at $171 found 3 days ago
Sat, Oct 17 - Sat, Oct 24
SJU
San Juan
SDQ
Santo Domingo
$211 Roundtrip, found 6 days ago
$211
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sat, Oct 17 from San Juan to Santo Domingo, returning Sat, Oct 24, priced at $211 found 6 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Xeliter Balcones del Atlantico
4.5-star property

Xeliter Balcones del Atlantico

8.2/10 Very Good! (186 reviews)

Jul 15 - Jul 18

3 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • Coach
Save 100% on your flight
Price was $953, price is now $582 per person
$582
per person
found 1 day ago
Close to the beach, beautiful vegetation and quiet location. Unfortunately I was not able to sleep. The air conditioning was set so cold and there were no blankets. Additionally there was no access to internet.

Reviewed on Feb 24, 2025

Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

7.8/10 Good! (2,572 reviews)

Jun 28 - Jul 2

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • Coach
Save 100% on your flight
Price was $1,309, price is now $609 per person
$609
per person
found 1 day ago
Place and staff was awesome would def be bk Food was great

Reviewed on Oct 14, 2025

Bahia Principe Explore El Portillo - All Inclusive
4.0-star property

Bahia Principe Explore El Portillo - All Inclusive

8.4/10 Very Good! (1,000 reviews)

Jun 30 - Jul 3

3 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • Coach
Save 100% on your flight
Price was $1,059, price is now $661 per person
$661
per person
found 22 hours ago
The food options were not great at the restaurants. Entertainment staff worked hard and did a good job for all the guests Bartenders at the pool bar were great. Chef at Boho were great

Reviewed on Jan 31, 2024

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Santo Domingo packages with premium economy flights

Price found within the past 48 hours. Click for updated prices.
Eurostars Grand Cayacoa
4.5-star property

Eurostars Grand Cayacoa

8.2/10 Very Good! (622 reviews)

Jul 12 - Jul 16

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Price was $1,330, price is now $937 per person
$937
per person
found 17 hours ago
Beautiful people, awesome place and service! Very much pleased 😀

Reviewed on Jan 29, 2024

Bahia Principe Explore La Romana - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - All Inclusive

8.4/10 Very Good! (2,636 reviews)

Jul 4 - Jul 11

7 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Save 100% on your flight
Price was $1,895, price is now $1,145 per person
$1,145
per person
found 11 hours ago
The best part about our stay at the property was the staff everyone was very nice and attentive to our toddlers. The staff from the kids club went out of their way to make them feel included in the activities. Such a family friendly experience. The water pressure in the shower wasn’t great and the water wasn’t too warm although my husband thought it was fine. The food was really good they had a lot of options.

Reviewed on Apr 26, 2026

Bahia Principe Escape Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,730 reviews)

Jul 4 - Jul 11

7 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Price was $1,307, price is now $1,300 per person
$1,300
per person
found 11 hours ago
The room was large and beautiful. The property is easy to walk and navigate and beautiful. The staff are helpful, kind and friendly. We were impressed by them. Love that the hotel has its own song and dance! The pools were great, food was great! The entertainment was great and got visitors participating. Highly recommend!

Reviewed on May 19, 2026

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More About Flying To Santo Domingo from Mayagüez

Route Information for Flights from Mayagüez to Santo Domingo

Origin Airport IATA Code
SJU
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mayagüez to Santo Domingo

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Frequently asked questions

Are there non-stop flights from Mayaguez to Santo Domingo?
Yes, JetBlue flies straight from Mayaguez to Santo Domingo, so you'll be embarking on your unforgettable adventure before you know it.
What is the shortest flight from Mayaguez to Santo Domingo?
If conditions are good and there are no delays, you could be coming in to land at Santo Domingo (SDQ-Las Americas Intl.) from Luis Munoz Marin Intl. Airport (SJU) in only 2 hours and 10 minutes. With such a fast flight time, contemplate traveling with just carry-on luggage.
What airlines fly from Mayaguez to Santo Domingo most frequently?
If you're looking for the carrier with the most frequent flights from Isla Verde Intl. Airport to Santo Domingo (SDQ-Las Americas Intl.), buckle up and take off with JetBlue. This airline offers 91 flights every month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.