Hotels with Air Conditioning in Southeast Missouri
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Southeast Missouri Hotels with Air Conditioning

OYO Hickory House Inn
1802 N Outer Rd, Dexter, MO
Free Cancellation
Reserve now, pay when you stay
$57 nightly
The price is $63 total per night
$63 total
Dec 12 - Dec 13
Total with taxes and fees
At OYO Hickory House Inn, guests have access to free WiFi in public areas and laundry facilities. You can put free parking to good use if you drive. Front-desk staff are standing by 24/7 to assist with any requests.
Pet friendly
Parking included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $72 total per night
$72 total
Nov 16 - Nov 17
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.
Breakfast included
Pet friendly

Super 8 by Wyndham Pevely
1711 Highway Z, Pevely, MO
At Super 8 by Wyndham Pevely, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $96 total per night
$96 total
Nov 16 - Nov 17
Total with taxes and fees
Guests of Best Western Plus Sikeston have access to an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a computer station, and express check-out.
Pool
Breakfast included

Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd, Cape Girardeau, MO
Free Cancellation
$77 nightly
The price is $92 total per night
$92 total
Nov 16 - Nov 17
Total with taxes and fees
At Candlewood Suites Cape Girardeau by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include meeting rooms, a business center, and free newspapers.
Pool
Pet friendly

Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
Free Cancellation
Reserve now, pay when you stay
$82 nightly
The price is $93 total per night
$93 total
Nov 16 - Nov 17
Total with taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and tours or tickets. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Breakfast included
Parking included

Quality Inn Perryville I-55
1517 S. Perryville Blvd., Perryville, MO
Free Cancellation
Reserve now, pay when you stay
$67 nightly
The price is $77 total per night
$77 total
Nov 20 - Nov 21
Total with taxes and fees
Guests of Quality Inn Perryville I-55 have access to an outdoor pool, a gym, and a hot tub. You can put free parking to good use if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Pool
Hot Tub

Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd, Jackson, MO
Free Cancellation
Reserve now, pay when you stay
$87 nightly
The price is $94 total per night
$94 total
Dec 7 - Dec 8
Total with taxes and fees
At Comfort Suites Jackson-Cape Girardeau, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Breakfast included

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
100 Matthews Lane, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$59 nightly
The price is $68 total per night
$68 total
Nov 13 - Nov 14
Total with taxes and fees
Guests of Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) enjoy free WiFi in public areas, coffee in a common area, and a vending machine. If you drive, take advantage of free parking. The 24-hour front desk has staff always at the ready.
Breakfast included
Pet friendly

Crown Pointe Lodge, BW Signature Collection
4245 Hunt Rd, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $113 total per night
$113 total
Nov 19 - Nov 20
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection features a golf course, an indoor pool, and a gym. There's free parking and an area shuttle. The 24-hour front desk has staff always at the ready. Other amenities at this golf hotel include free WiFi in public areas, a hot tub, and a business center.
Pool
Hot Tub

Econo Lodge
110 Independence Ave, Kennett, MO
Free Cancellation
Reserve now, pay when you stay
$49 nightly
The price is $56 total per night
$56 total
Dec 11 - Dec 12
Total with taxes and fees
Econo Lodge features free WiFi in public areas, a seasonal outdoor pool, and coffee in a common area. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. Other amenities at this golf hotel include free newspapers, laundry facilities, and a TV in a common area.
Pool
Breakfast included

Days Inn by Wyndham Perryville
1500 Liberty Street, Perryville, MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $80 total per night
$80 total
Nov 13 - Nov 14
Total with taxes and fees
Guests of Days Inn by Wyndham Perryville enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. You can put free parking to good use if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include coffee/tea in a common area, free newspapers, and laundry facilities.
Pool
Breakfast included

Dexter Inn
1807 W Business US Highway 60, Dexter, MO
Free Cancellation
$62 nightly
The price is $70 total per night
$70 total
Nov 13 - Nov 14
Total with taxes and fees
Guests of Dexter Inn enjoy access to free WiFi in public areas, meeting rooms, and a seasonal outdoor pool. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include coffee/tea in a common area, laundry facilities, and an ATM.
Pool
Pet friendly

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Nov 16 - Nov 17
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84, Hayti, MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $107 total per night
$107 total
Nov 23 - Nov 24
Total with taxes and fees
At Drury Inn & Suites Hayti Caruthersville, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 600 hotels |
|---|---|
Lowest Price | $56 |
Highest Price | $113 |
Popular hotels | OYO Hickory House Inn, Days Inn and Suites by Wyndham Sikeston, Super 8 by Wyndham Pevely, Best Western Plus Sikeston, Candlewood Suites Cape Girardeau by IHG, Comfort Inn Festus - St Louis South, Quality Inn Perryville I-55, Comfort Suites Jackson-Cape Girardeau, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Crown Pointe Lodge, BW Signature Collection, Econo Lodge, Days Inn by Wyndham Perryville, Dexter Inn, Drury Inn & Suites Cape Girardeau, Drury Inn & Suites Hayti Caruthersville |
Recent Hotels with Air Conditioning Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
5/5 Excellent
"Thanks "
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Posted 4 days ago
More to Explore
- 3 Star Hotels in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Cabin Rentals in Fredericktown
- Condo Rentals in Fredericktown
- Cottages in Fredericktown
- Pet Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- Hotels near Millstream Gardens Conservation Area
- B&B in Pilot Knob
- Kid Friendly Hotels in Pilot Knob
- Hotels with Pool in Pilot Knob
- Hotels with Air Conditioning in Pilot Knob
- Pilot Knob Hotels
- Cottages in Middle Brook
- Cobalt Hotels
- Mill Spring Hotels
- Motels in Mill Spring
- Hotels with Pool in Ellington
- Des Arc Hotels
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Pet Friendly Hotels in Piedmont
- Piedmont Hotels
- Lodges in Piedmont
- Motels in Piedmont
- Cabin Rentals in Marble Hill
- Hotels near Fort Davidson State Historic Site
- 3 Star Hotels in Ironton
- B&B in Ironton
- Cottages in Ironton
- Cheap Hotels in Ironton
- Historic Hotels in Ironton
- Hotels with Bar in Ironton
- Ironton Hotels
- Motels in Ironton
- Vacation Homes in Ironton
- Hotels near Taum Sauk Mountain State Park
- 2 Star Hotels in Central Fredericktown
- Historic Hotels in Caledonia
- B&B in Annapolis
- Cabin Rentals in Annapolis
- Vacation Homes in Annapolis
- Hotels with Airport Transfers in St. Louis
- Beach Resorts & in Park Hills
- Hotels with Pool in Park Hills
- Hotels near Elephant Rocks State Park
- 4 Star Hotels in Lesterville
- Apartments in Lesterville
- Cabin Rentals in Lesterville
- Cottages in Lesterville
- Kid Friendly Hotels in Lesterville
- Hotels with Pool in Lesterville
- Pet Friendly Hotels in Lesterville
- Lodges in Lesterville
- Vacation Homes in Lesterville
- 3 Star Hotels in Arcadia
- 4 Star Hotels in Arcadia
- Cabin Rentals in Arcadia
- Cottages in Arcadia
- Hotels with Pool in Arcadia
- Motels in Arcadia
- All Inclusive Resorts & in Downtown St. Louis
- Hotels with a Gym in Downtown St. Louis
- Hotels with Room Service in Downtown St. Louis
- Luxury Hotels in Downtown St. Louis
- Hotels on the River in Downtown St. Louis
- Hotels with Shopping in Downtown St. Louis
- Apartments in Arcadia Valley Station
- Cabin Rentals in Arcadia Valley Station
- Hotels near K Bridge Recreation Area
- Lodges in Greenville
- Rv Parks in Greenville
- Resorts in Greenville
- Casino Resorts & in Farmington
- Cheap Hotels in Farmington
- Kid Friendly Hotels in Farmington
- Golf Resorts & in Farmington
- Historic Hotels in Farmington
- Hotels with Pool in Farmington
- Hotels with Hot Tubs in Farmington
- Hotels with an Indoor Pool in Farmington
- Luxury Hotels in Farmington
- Pet Friendly Hotels in Farmington
- Romantic Getaways & Hotels in Farmington
- Spa Resorts & in Farmington
- Hotels with a Wedding Venue in Farmington
- Winery Hotels in Farmington


