Hotels with Restaurants in Southeast Missouri
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Southeast Missouri Hotels with Restaurants

Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84 Hayti MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $107 total per night
$107 total
Jan 9 - Jan 10
Total with taxes and fees
At Drury Inn & Suites Hayti Caruthersville, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Free Cancellation
Reserve now, pay when you stay
$83 nightly
The price is $88 total per night
$88 total
Jan 4 - Jan 5
Total with taxes and fees
Guests of Drury Inn & Suites Jackson MO have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $103 total per night
$103 total
Jan 6 - Jan 7
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $119 total per night
$119 total
Jan 8 - Jan 9
Total with taxes and fees
At Hampton Inn Cape Girardeau I 55 East, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$105 nightly
The price is $119 total per night
$119 total
Jan 10 - Jan 11
Total with taxes and fees
Drury Inn & Suites Poplar Bluff features an indoor pool, an outdoor pool, and a gym. A stay here includes free parking. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include free WiFi in public areas, a hot tub, and meeting rooms.
Pool
Hot Tub

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
$54 nightly
The price is $61 total per night
$61 total
Jan 9 - Jan 10
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Free Cancellation
$110 nightly
The price is $124 total per night
$124 total
Jan 8 - Jan 9
Total with taxes and fees
At Holiday Inn Poplar Bluff by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Pet friendly

Best Western Plus Sikeston
120 S Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$77 nightly
The price is $88 total per night
$88 total
Jan 6 - Jan 7
Total with taxes and fees
Guests of Best Western Plus Sikeston have access to an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a computer station, and express check-out.
Pool
Breakfast included

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Jan 6 - Jan 7
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy free WiFi in public areas, a 24-hour business center, and a TV in a common area. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations.
Breakfast included
Pet friendly

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Jan 6 - Jan 7
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$112 nightly
The price is $125 total per night
$125 total
Feb 1 - Feb 2
Total with taxes and fees
Guests of Hampton Inn Poplar Bluff have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Guests of this apartment enjoy access to a water park, laundry facilities, and barbecue grills.
Kitchen
Washer

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Jan 6 - Jan 7
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Jan 6 - Jan 7
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau Near the Medical Center enjoy free WiFi in public areas, coffee in a common area, and express check-out. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free hotel also has a TV in a common area.
Pet friendly
Free WiFi

Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $86 total per night
$86 total
Jan 4 - Jan 5
Total with taxes and fees
At Comfort Suites Jackson-Cape Girardeau, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 622 hotels |
|---|---|
Lowest Price | $61 |
Highest Price | $125 |
Popular hotels | Drury Inn & Suites Hayti Caruthersville, Drury Inn & Suites Jackson MO, Drury Inn & Suites Sikeston, MO, Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Poplar Bluff, Baymont Inn and Suites by Wyndham Farmington, MO, Holiday Inn Poplar Bluff by IHG, Best Western Plus Sikeston, Pear Tree Inn Cape Girardeau West, Drury Plaza Hotel Cape Girardeau Conference Center, Hampton Inn Poplar Bluff, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Drury Inn & Suites Cape Girardeau, Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Suites Jackson-Cape Girardeau |
Recent Hotels with Restaurants Reviews

Drury Plaza Hotel Cape Girardeau Conference Center
5/5 Excellent
"Always a pleasant stay. Friendly staff, clean rooms, accessible pool and great food."
A verified traveler stayed at Drury Plaza Hotel Cape Girardeau Conference Center
Posted 6 days ago
More to Explore
- B&B in Annapolis
- Cabin Rentals in Annapolis
- Vacation Homes in Annapolis
- 3 Star Hotels in Arcadia
- 4 Star Hotels in Arcadia
- Cabin Rentals in Arcadia
- Cottages in Arcadia
- Hotels with Pool in Arcadia
- Motels in Arcadia
- 4 Star Hotels in Lesterville
- Apartments in Lesterville
- Cabin Rentals in Lesterville
- Cottages in Lesterville
- Kid Friendly Hotels in Lesterville
- Hotels with Pool in Lesterville
- Pet Friendly Hotels in Lesterville
- Lodges in Lesterville
- Vacation Homes in Lesterville
- Mill Spring Hotels
- Motels in Mill Spring
- Cottages in Middle Brook
- Cobalt Hotels
- All Inclusive Resorts & in Downtown St. Louis
- Hotels with a Gym in Downtown St. Louis
- Hotels with Room Service in Downtown St. Louis
- Luxury Hotels in Downtown St. Louis
- Hotels on the River in Downtown St. Louis
- Hotels with Shopping in Downtown St. Louis
- Hotels with Airport Transfers in St. Louis
- Beach Resorts & in Park Hills
- Hotels with Pool in Park Hills
- Hotels near Fort Davidson State Historic Site
- Cabin Rentals in Marble Hill
- Casino Resorts & in Farmington
- Cheap Hotels in Farmington
- Kid Friendly Hotels in Farmington
- Golf Resorts & in Farmington
- Historic Hotels in Farmington
- Hotels with Pool in Farmington
- Hotels with Hot Tubs in Farmington
- Hotels with an Indoor Pool in Farmington
- Luxury Hotels in Farmington
- Pet Friendly Hotels in Farmington
- Romantic Getaways & Hotels in Farmington
- Spa Resorts & in Farmington
- Hotels with a Wedding Venue in Farmington
- Winery Hotels in Farmington
- 3 Star Hotels in Ironton
- B&B in Ironton
- Cottages in Ironton
- Cheap Hotels in Ironton
- Historic Hotels in Ironton
- Hotels with Bar in Ironton
- Ironton Hotels
- Motels in Ironton
- Vacation Homes in Ironton
- Hotels near Taum Sauk Mountain State Park
- B&B in Pilot Knob
- Kid Friendly Hotels in Pilot Knob
- Hotels with Pool in Pilot Knob
- Hotels with Air Conditioning in Pilot Knob
- Pilot Knob Hotels
- Hotels near Millstream Gardens Conservation Area
- Hotels with Pool in Ellington
- Des Arc Hotels
- Hotels near K Bridge Recreation Area
- Hotels near Elephant Rocks State Park
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Pet Friendly Hotels in Piedmont
- Piedmont Hotels
- Lodges in Piedmont
- Motels in Piedmont
- Lodges in Greenville
- Rv Parks in Greenville
- Resorts in Greenville
- 2 Star Hotels in Central Fredericktown
- Historic Hotels in Caledonia
- 3 Star Hotels in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Cabin Rentals in Fredericktown
- Condo Rentals in Fredericktown
- Cottages in Fredericktown
- Pet Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- Apartments in Arcadia Valley Station
- Cabin Rentals in Arcadia Valley Station


