$198 Cheap flight deals from Myrtle Beach (MYR) to Middlesboro (TYS)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Myrtle Beach to Middlesboro

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 12 - Fri, Jul 18
MYR
Myrtle Beach Intl.
TYS
McGhee Tyson
$314 Roundtrip, found 2 days ago
$314
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jul 12 from Myrtle Beach Intl. to McGhee Tyson, returning Fri, Jul 18, priced at $314 found 2 days ago

Airfares from $198 One Way, $238 Round Trip from Myrtle Beach to Middlesboro

Prices starting at $238 for return flights and $198 for one-way flights to Middlesboro were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jul 22 - Tue, Jul 29
MYR
Myrtle Beach
TYS
Knoxville
$238 Roundtrip, found 1 day ago
$238
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 22 from Myrtle Beach to Knoxville, returning Tue, Jul 29, priced at $238 found 1 day ago
Thu, Jul 17 - Tue, Jul 29
MYR
Myrtle Beach
TYS
Knoxville
$255 Roundtrip, found 1 day ago
$255
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jul 17 from Myrtle Beach to Knoxville, returning Tue, Jul 29, priced at $255 found 1 day ago
Tue, Jul 22 - Sun, Jul 27
MYR
Myrtle Beach
TYS
Knoxville
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 22 from Myrtle Beach to Knoxville, returning Sun, Jul 27, priced at $258 found 1 day ago
Thu, Jul 17 - Mon, Jul 21
MYR
Myrtle Beach
TYS
Knoxville
$260 Roundtrip, found 1 day ago
$260
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jul 17 from Myrtle Beach to Knoxville, returning Mon, Jul 21, priced at $260 found 1 day ago
Wed, Jul 9 - Thu, Jul 17
MYR
Myrtle Beach
TYS
Knoxville
$268 Roundtrip, found 2 days ago
$268
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Jul 9 from Myrtle Beach to Knoxville, returning Thu, Jul 17, priced at $268 found 2 days ago

Middlesboro economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hilton Knoxville
3.5-star property

Hilton Knoxville

8.6/10 Excellent! (1,489 reviews)

Aug 15 - Aug 17

2 night stay

Myrtle Beach (MYR) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
per person
found 21 hours ago
The location and staff were excellent…we had issues with the air conditioning unit but it wasn’t bad , we would say overall excellent stay

Reviewed on Apr 17, 2025

The Oliver Hotel
3.5-star property

The Oliver Hotel

9.6/10 Exceptional! (567 reviews)

Aug 15 - Aug 17

2 night stay

Myrtle Beach (MYR) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
per person
found 21 hours ago
The Oliver Hotel in Knoxville is right on the square in downtown. It is advertised as a 'boutique' hotel and that is a perfect description of the hotel. I was allowed to check in early, and upon my request for an upgrade to my room booking at a nominal cost, I was upgraded at no charge. The hotel seems to be a renovated property, and the rooms are outfitted in a 70's motif, with brass dome lights and decor. The bed was very comfortable, and the bathroom classically stylish. The water pressure in the shower left something to be desired, and that is often a result of an older structure renovation. The rooms are not exactly soundproof, other guests can occasionally be heard. The only criticism of the room are the bath linens; an upgrade would put this hotel another notch up, There is no swimming pool nor fitness center, again indicative of a boutique hotel. The staff was accommodating, and stretched thin; the front desk staff seem to perform numerous functions such as typical front desk activities, to running the valet, to accommodating guest requests. Often there is a sign on the desk explaining this and a promise to 'be right back'. In all instances this was the case, the desk is not unmanned for long. There are bicycles guests can check out for free. The room attendants did a great job, my room was cleaned daily. Great stay, accommodating snd friendly staff, and hidden behind a slide door is the Peter Kern Library, a speakeasy bar where you will share booths.

Reviewed on Jun 17, 2025

THE TENNESSEAN Hotel
4.0-star property

THE TENNESSEAN Hotel

9.6/10 Exceptional! (1,001 reviews)

Aug 15 - Aug 17

2 night stay

Myrtle Beach (MYR) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
per person
found 21 hours ago
Great hotel! Everything was clean and the staff was very helpful. Would stay here again!

Reviewed on Jul 6, 2025

Don't see what you're looking for?
See all available trips from Myrtle Beach to Middlesboro
View all trips

More About Flying To Middlesboro from Myrtle Beach

Route Information for Flights from Myrtle Beach to Middlesboro

Origin Airport IATA Code
MYR
Destination Airport IATA Code
TYS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Myrtle Beach to Middlesboro

Planning a romantic getaway, traveling the world at last or flying out to see the kids and grandkids? Orbitz On-the-Go saves you both time and money. Our cutting edge mobile tools and guaranteed low prices leave plenty of room in your budget for the important things in life. Find same-day deals on domestic flights from Myrtle Beach to Middlesboro, and bargain sales on international Myrtle Beach to Middlesboro flights.

Family Matters, and So Do Cheap Tickets

Don’t miss another birthday, graduation or wedding, wherever they are. Take advantage of Orbitz On-the-Go’s discount travel planning features to save on flights from Myrtle Beach to Middlesboro and Myrtle Beach to Middlesboro flights. Tell them you’ll be there, every single time.

Escape to Romance

Treat yourself and the one you love to a romantic hideaway. Orbitz budget air flights from Myrtle Beach to Middlesboro and Myrtle Beach to Middlesboro flights can be bundled into packages for extravagant savings at spa resorts and hotels.

See the World

It’s finally your time. Go wherever the wind takes you. Orbitz On-the-Go makes dreams come true. Book low fare flights from Myrtle Beach to Middlesboro, the world is at your fingertips.

Flight or Gate Changes? No Problem

Once you’ve reserved your low cost air ticket on Myrtle Beach to Middlesboro flights or flights from Myrtle Beach to Middlesboro, stay informed with Orbitz On-the-Go free alerts. Choose from email, voice and text notification. You’ll always know your flight status and gate number, and where and how to pick up your bags.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.