$309 Cheap flight deals from Panama City (PTY) to Santiago (SCL)

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This Weekend's Flight Deals from Panama City to Santiago

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 30 - Wed, Nov 4
PTY
Tocumen Intl.
SCL
Arturo Merino Benitez
$677 Roundtrip, found 10 hours ago
$677
Roundtrip
found 10 hours ago
Select avianca flight, departing Fri, Oct 30 from Tocumen Intl. to Arturo Merino Benitez, returning Wed, Nov 4, priced at $677 found 10 hours ago

Airfares from $309 One Way, $677 Round Trip from Panama City to Santiago

Prices starting at $677 for return flights and $309 for one-way flights to Santiago were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 9 - Sat, Apr 24
PTY
Panama City
SCL
Santiago
$677 Roundtrip, found 1 hour ago
$677
Roundtrip
found 1 hour ago
Select avianca flight, departing Fri, Apr 9 from Panama City to Santiago, returning Sat, Apr 24, priced at $677 found 1 hour ago
Fri, Apr 9 - Sat, Apr 24
PTY
Panama City
SCL
Santiago
$679 Roundtrip, found 1 hour ago
$679
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Apr 9 from Panama City to Santiago, returning Sat, Apr 24, priced at $679 found 1 hour ago
Wed, Dec 9 - Sat, Dec 12
PTY
Panama City
SCL
Santiago
$698 Roundtrip, found 6 hours ago
$698
Roundtrip
found 6 hours ago
Select avianca flight, departing Wed, Dec 9 from Panama City to Santiago, returning Sat, Dec 12, priced at $698 found 6 hours ago
Wed, Dec 9 - Sat, Dec 12
PTY
Panama City
SCL
Santiago
$720 Roundtrip, found 6 hours ago
$720
Roundtrip
found 6 hours ago
Select avianca flight, departing Wed, Dec 9 from Panama City to Santiago, returning Sat, Dec 12, priced at $720 found 6 hours ago
Sat, Jan 23 - Sat, Jan 30
PTY
Panama City
SCL
Santiago
$731 Roundtrip, found 4 days ago
$731
Roundtrip
found 4 days ago
Select Copa flight, departing Sat, Jan 23 from Panama City to Santiago, returning Sat, Jan 30, priced at $731 found 4 days ago

Santiago economy flight packages

Price found within the past 48 hours. Click for updated prices.
Park Plaza Apart Hotel
3.0-star property

Park Plaza Apart Hotel

8.6/10 Excellent! (704 reviews)

Nov 30 - Dec 7

7 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $1,005, price is now $839 per person
$839
per person
found 1 day ago

45 by Director
3.5-star property

45 by Director

9/10 Wonderful! (511 reviews)

Nov 30 - Dec 7

7 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $1,200, price is now $937 per person
$937
per person
found 1 day ago

Hyatt Place Santiago/Vitacura
3.5-star property

Hyatt Place Santiago/Vitacura

9/10 Wonderful! (1,006 reviews)

Nov 30 - Dec 7

7 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $1,186, price is now $998 per person
$998
per person
found 1 day ago
Todo muy limpio

Reviewed on Oct 21, 2026

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More About Flying To Santiago from Panama City

Route Information for Flights from Panama City to Santiago

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SCL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santiago

Panama City to Santiago flights are offered at fantastic discount by Orbitz. Book air tickets now and cut those extra costs out of your travel budget to ensure a rewarding travel experience. With guaranteed low prices like these, can you afford to miss this discount?

Book cheap flights from Panama City to Santiago

Cheap airfares are available on flights from Panama City to Santiago. Use Orbitz to find the best flights that suit both your budget and the travel times that you need. Travelers who are looking for discounted rates on domestic or international flights need to look no further than Orbitz.

Orbitz goes mobile

As the world of technology rapidly expands around us, we are continuously finding new ways to improve our services, communications, and accessibility. With our cutting-edge mobile tools now available on Android, iPhone, and tablets, you can access detailed information on your bookings for flights from Panama City to Santiago at any time or anywhere. See your itinerary for your Panama City to Santiago flights, baggage and gate claim details, as well as hotel deals with our easy-to-use apps.

Get a great package with your Panama City to Santiago flights

With frequent updates on your flight status, including delays and changes in bookings, traveling becomes more hassle-free than ever. Not only do we offer huge discounted deals on flights from Panama City to Santiago, we also have fantastic savings on vacation packages, hotel room, cruises, activities, and car rentals so you can pick and choose and create the best travel package for you.

Frequently asked questions

Are there non-stop flights from Panama City to Santiago?
Yep, Copa Airlines flies directly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL), so you'll be touching down and starting your unforgettable adventure in no time.
What is the shortest flight from Panama City to Santiago?
The fastest flight time from Panama City to Santiago is 7 hours and 20 minutes, which gives you more than enough time to enjoy a wine or get carried away with a good book.
What airlines fly from Panama City to Santiago most frequently?
If you're on the hunt for the carrier with the most flights from PTY to Nuevo Pudahuel Airport, book your ticket with Copa Airlines. This carrier offers 91 flights each month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.