$379 Cheap flight deals from Panama City (PTY) to Santiago (SCL)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Panama City to Santiago

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 21 - Sun, Aug 23
PTY
Tocumen Intl.
SCL
Arturo Merino Benitez
$679 Roundtrip, found 4 days ago
$679
Roundtrip
found 4 days ago
Select avianca flight, departing Fri, Aug 21 from Tocumen Intl. to Arturo Merino Benitez, returning Sun, Aug 23, priced at $679 found 4 days ago

Airfares from $379 One Way, $629 Round Trip from Panama City to Santiago

Prices starting at $629 for return flights and $379 for one-way flights to Santiago were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Oct 20 - Sat, Oct 31
PTY
Panama City
SCL
Santiago
$629 Roundtrip, found 2 hours ago
$629
Roundtrip
found 2 hours ago
Select avianca flight, departing Tue, Oct 20 from Panama City to Santiago, returning Sat, Oct 31, priced at $629 found 2 hours ago
Sat, Oct 24 - Sat, Nov 28
PTY
Panama City
SCL
Santiago
$679 Roundtrip, found 6 days ago
$679
Roundtrip
found 6 days ago
Select Copa flight, departing Sat, Oct 24 from Panama City to Santiago, returning Sat, Nov 28, priced at $679 found 6 days ago
Mon, Aug 24 - Tue, Aug 25
PTY
Panama City
SCL
Santiago
$694 Roundtrip, found 4 days ago
$694
Roundtrip
found 4 days ago
Select Copa flight, departing Mon, Aug 24 from Panama City to Santiago, returning Tue, Aug 25, priced at $694 found 4 days ago
Wed, Dec 9 - Sun, Dec 27
PTY
Panama City
SCL
Santiago
$695 Roundtrip, found 3 hours ago
$695
Roundtrip
found 3 hours ago
Select Copa flight, departing Wed, Dec 9 from Panama City to Santiago, returning Sun, Dec 27, priced at $695 found 3 hours ago
Fri, Oct 23 - Fri, Nov 27
PTY
Panama City
SCL
Santiago
$699 Roundtrip, found 6 days ago
$699
Roundtrip
found 6 days ago
Select Copa flight, departing Fri, Oct 23 from Panama City to Santiago, returning Fri, Nov 27, priced at $699 found 6 days ago

Santiago economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Panamericano
3.0-star property

Hotel Panamericano

8.6/10 Excellent! (233 reviews)

Sep 23 - Sep 28

5 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $982, price is now $837 per person
$837
per person
found 10 hours ago
Excelente hotel

Reviewed on Jul 24, 2026

Aubrey Hotel Boutique
4.0-star property

Aubrey Hotel Boutique

9.4/10 Exceptional! (151 reviews)

Sep 23 - Sep 28

5 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $1,291, price is now $1,003 per person
$1,003
per person
found 10 hours ago
Room was excellent. Had a problem at checkout. Major language barrier

Reviewed on Feb 18, 2026

Hotel Sommelier Agustinas
3.0-star property

Hotel Sommelier Agustinas

8.6/10 Excellent! (256 reviews)

Sep 23 - Sep 28

5 night stay

Panama City (PTY) to Santiago (SCL)

Copa • Roundtrip • Coach
Price was $1,052, price is now $871 per person
$871
per person
found 10 hours ago
Good location for visiting the sights of the central city. The room was very spacious, with a small kitchen and living space separate from the bedroom. The breakfast had a good range and was well stocked. The rooftop bar was a good spot for a refreshment after a day exploring the sights. The only negative was that our we could hear the noise from the bar in our 5th floor room.

Reviewed on May 12, 2026

Don't see what you're looking for?
See all available trips from Panama City to Santiago
View all trips

More About Flying To Santiago from Panama City

Route Information for Flights from Panama City to Santiago

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SCL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santiago

Those who want guaranteed low prices for Panama City to Santiago flights only need to visit Orbitz. We take advantage of the latest mobile technologies to make sure you get the best bargain on your trip and that everything goes smoothly and according to your plans.

Take Advantage of Orbitz’s Amazing Customer Service on Panama City to Santiago Flights

We will help you from booking to boarding on flights from Panama City to Santiago. Whether you have questions about baggage limits, seat assignments or anything else, we will be there to answer them for you.

Get Great Recommendations For Travel Ideas On Orbitz.com

We do not only get the best bargains on flights from Panama City to Santiago, but we can tell you what to do once you get there. Whether it is a music festival, hotel recommendation or list of local attractions, Orbitz can help make your travel plan more exciting.

Combine Car Rental With Your Discount Flight For Even More Savings

Not only can we get bargain deals on flights from Panama City to Santiago but we can book your transport as well. By combining car rental with Panama City to Santiago flights, you can be sure to save money and start moving as soon as you hit the ground.

Use Orbitz On The Go To Stay Informed Using Your Smartphone

This convenient app works with most smartphones and allows you to see the status of flights from Panama City to Santiago. You don’t have to worry, if something goes wrong, we’ll let you know.

Frequently asked questions

Are there non-stop flights from Panama City to Santiago?
Yep, Copa Airlines flies directly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL), so you'll be touching down and starting your unforgettable adventure in no time.
What is the shortest flight from Panama City to Santiago?
The fastest flight time from Panama City to Santiago is 7 hours and 20 minutes, which gives you more than enough time to enjoy a wine or get carried away with a good book.
What airlines fly from Panama City to Santiago most frequently?
If you're on the hunt for the carrier with the most flights from PTY to Nuevo Pudahuel Airport, book your ticket with Copa Airlines. This carrier offers 91 flights each month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.