Hotels with Casino in Sikeston, MO
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Featured Sikeston Casino Resorts & Hotels

Town House Inn Cape Giradreau
505 North Kingshighway Street Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$57 nightly
The price is $64 total per night
$64 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Town House Inn Cape Giradreau features free WiFi in public areas and a vending machine. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready.
Pet friendly
Parking included

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Free Cancellation
$95 nightly
The price is $107 total per night
$107 total
Dec 22 - Dec 23
Total with taxes and fees
At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and luggage storage. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
Pool
Breakfast included

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Dec 21 - Dec 22
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau Near the Medical Center enjoy free WiFi in public areas, coffee in a common area, and express check-out. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free hotel also has a TV in a common area.
Pet friendly
Free WiFi

Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd Cape Girardeau MO
Free Cancellation
$70 nightly
The price is $84 total per night
$84 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At Candlewood Suites Cape Girardeau by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include meeting rooms, a business center, and free newspapers.
Pool
Pet friendly

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Dec 21 - Dec 22
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy free WiFi in public areas, a 24-hour business center, and a TV in a common area. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations.
Breakfast included
Pet friendly

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Dec 21 - Dec 22
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Quality Inn
2011 North Kingshighway Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $67 total per night
$67 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests of Quality Inn Cape Girardeau North enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a vending machine, and a TV in a common area.
Pool
Breakfast included

Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $86 total per night
$86 total
Dec 28 - Dec 29
Total with taxes and fees
At Comfort Suites Jackson-Cape Girardeau, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Sikeston hotels essential information
Accommodation | 285 hotels |
|---|---|
Lowest Price | $64 |
Highest Price | $107 |
Popular hotels | Town House Inn Cape Giradreau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, Pear Tree Inn Cape Girardeau Near the Medical Center, Candlewood Suites Cape Girardeau by IHG, Pear Tree Inn Cape Girardeau West, Drury Inn & Suites Cape Girardeau, Quality Inn, Comfort Suites Jackson-Cape Girardeau |
Recent Casino Resorts & Hotels Reviews

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
5/5 Excellent
"Very clean environment. Staff is very nice and friendly. Will not mind staying here again in future. "
A verified traveler stayed at Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Posted 1 day ago
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