Book 5 Star Hotels in Southeast Missouri

Name: The Farmstead Hotel
Price range: $108 total

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Dec 22 - Dec 23

Tonight

Dec 23 - Dec 24

Tomorrow night

Featured Southeast Missouri 5 Stars Hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Free Cancellation

Reserve now, pay when you stay

37.99 mi from city center

$53 nightly

$60 total

Dec 28 - Dec 29

Total with taxes and fees

Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.

Pool

Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center

Free Cancellation

Reserve now, pay when you stay

46.88 mi from city center

$90 nightly

$102 total

Dec 28 - Dec 29

Total with taxes and fees

At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.

Pool

Hot Tub

Free Cancellation

Reserve now, pay when you stay

29.15 mi from city center

$76 nightly

$80 total

Dec 23 - Dec 24

Total with taxes and fees

Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with luggage storage and tours/tickets.

Pet friendly

Parking included

Free Cancellation

Reserve now, pay when you stay

50.35 mi from city center

$107 nightly

$121 total

Dec 23 - Dec 24

Total with taxes and fees

Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and wedding services.

Parking included

Free WiFi

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Free Cancellation

Reserve now, pay when you stay

45.7 mi from city center

$84 nightly

$91 total

Jan 7 - Jan 8, 2026

Total with taxes and fees

At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a vending machine.

Pool

Breakfast included

Free Cancellation

Reserve now, pay when you stay

53.02 mi from city center

$98 nightly

$110 total

Dec 28 - Dec 29

Total with taxes and fees

At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.

Pool

Breakfast included

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Free Cancellation

Reserve now, pay when you stay

68.37 mi from city center

$93 nightly

$106 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

Guests of La Quinta Inn & Suites by Wyndham Festus - St. Louis South enjoy a gym, free WiFi in public areas, and a business center. Free parking is available if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. This smoke-free hotel also has a convenience store.

Breakfast included

Pet friendly

Free Cancellation

Reserve now, pay when you stay

54.11 mi from city center

$90 nightly

$103 total

Dec 26 - Dec 27

Total with taxes and fees

Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.

Pool

Breakfast included

Free Cancellation

Reserve now, pay when you stay

83.3 mi from city center

$95 nightly

$108 total

Dec 23 - Dec 24

Total with taxes and fees

Guests of The Farmstead Hotel enjoy features like a casino, free WiFi in public areas, and microwave in a common area. A stay here includes free parking. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include an ATM and a TV in a common area.

Parking included

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in Southeast Missouri

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Southeast Missouri. After all, treating yourself to the finer things is what vacations are about.

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Southeast Missouri hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Southeast Missouri 5 star hotels and resorts typically offer luxury amenities such as:

Gourmet restaurant
Full-service fitness center with pool
Luxury spa
Welcome gifts upon arrival
Top-of-the-line beds and linens
Designer personal care products
Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Southeast Missouri with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place:

Search hotels by price, ranging from $60 to $121
Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
Choose from 620 5 star hotels in Southeast Missouri!

Southeast Missouri hotels essential information

Accommodation	620 hotels
Lowest Price	$60
Highest Price	$121
Popular hotels	Baymont Inn and Suites by Wyndham Farmington, MO, Drury Plaza Hotel Cape Girardeau Conference Center, Motel 6 Poplar Bluff, MO, The Riverview, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Hampton Inn Sikeston, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Drury Inn & Suites Sikeston, MO, The Farmstead Hotel

Recent Reviews

5/5 Excellent

"It was a nice stay."

A verified traveler stayed at Motel 6 Poplar Bluff, MO

Posted 21 hours ago

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