Find South Carolina Midlands Boutique Hotels
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Tomorrow night
Check prices in South Carolina Midlands for tomorrow night, Aug 3 - Aug 4Featured South Carolina Midlands Boutique Hotels

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$124 nightly
The price is $139 total per night
$139 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Parking included

The Inn at the Crossroads
128 West Main Street, Lake City, SC
Free Cancellation
Reserve now, pay when you stay
$134 nightly
The price is $150 total per night
$150 total
Aug 21 - Aug 22
Total includes taxes and fees
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.
Breakfast included
Parking included

The Mantissa Hotel
130 East Carolina Ave, Hartsville, SC
Free Cancellation
Reserve now, pay when you stay
$188 nightly
The price is $211 total per night
$211 total
Aug 3 - Aug 4
Total includes taxes and fees
Guests staying at The Mantissa Hotel enjoy a gym, a rooftop terrace, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center and a banquet hall.
Breakfast included
Parking included

Inn on the Square, Ascend Hotel Collection
104 Court Avenue East, Greenwood, SC
Free Cancellation
Reserve now, pay when you stay
$98 nightly
The price is $108 total per night
$108 total
Aug 10 - Aug 11
Total includes taxes and fees
Inn on the Square, Ascend Hotel Collection features free WiFi in public areas, meeting rooms, and a conference center. A stay here includes free parking. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and concierge services. Additional amenities include coffee/tea in a common area, a terrace, and wedding services.
Parking included
Free WiFi

Graduate by Hilton Columbia SC
1619 Pendleton Street, Columbia, SC
Free Cancellation
Reserve now, pay when you stay
$123 nightly
The price is $137 total per night
$137 total
Sep 1 - Sep 2
Total includes taxes and fees
Graduate by Hilton Columbia SC features a 24-hour gym, free WiFi in public areas, and conference space. Self parking is offered for USD 10 per night. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include coffee/tea in a common area, a library, and express check-in.
Pet friendly
Free WiFi

Hyatt Place Columbia/Downtown/The Vista
819 Gervais Street, Columbia, SC
Free Cancellation
Reserve now, pay when you stay
$119 nightly
The price is $133 total per night
$133 total
Sep 1 - Sep 2
Total includes taxes and fees
Guests of Hyatt Place Columbia/Downtown/The Vista have access to an indoor pool, a gym, and free WiFi in public areas. Valet parking is offered for USD 18.00 per day. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, securing valuables, and tours or tickets. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included

Sheraton Columbia Downtown Hotel
1400 Main St, Columbia, SC
Free Cancellation
Reserve now, pay when you stay
$107 nightly
The price is $120 total per night
$120 total
Aug 22 - Aug 23
Total includes taxes and fees
At Sheraton Columbia Downtown Hotel, guests have access to a 24-hour gym, free WiFi in public areas, and a business center. Valet parking is offered for USD 31.32 per night. The 24-hour front desk has staff standing by to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a computer station, express check-out, and a garden.
Free WiFi
Air conditioning

Lookaway Inn
103 W Forest Ave, North Augusta, SC
$149 nightly
The price is $167 total per night
$167 total
Aug 8 - Aug 9
Total includes taxes and fees
Guests of Lookaway Inn enjoy access to free WiFi in public areas, conference space, and coffee in a common area. Free parking is included with your stay. Additional amenities include free newspapers, a terrace, and a garden.
Breakfast included
Parking included

Quality Inn Kingstree
1610 N Longstreet St, Kingstree, SC
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $100 total per night
$100 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests of Quality Inn Kingstree enjoy access to free WiFi in public areas, meeting rooms, and a business center. There's free parking if you drive. Staff members can answer questions about accommodations, and also provide front-desk service during limited hours. Additional amenities include express check-in, express check-out, and a vending machine.
Pet friendly
Parking included
Don't see what you're looking for?
See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Carolina Midlands hotels essential information
Accommodation | 2,938 hotels |
---|---|
Lowest Price | $100 |
Highest Price | $211 |
Popular hotels | Hotel Florence, Tapestry Collection by Hilton, The Inn at the Crossroads, The Mantissa Hotel, Inn on the Square, Ascend Hotel Collection, Graduate by Hilton Columbia SC, Hyatt Place Columbia/Downtown/The Vista, Sheraton Columbia Downtown Hotel, Lookaway Inn, Quality Inn Kingstree |
Recent Boutique Hotels Reviews

Tru By Hilton Columbia Downtown
5/5 Excellent
"Upon arrival we were greeting with a very warm welcome at the front desk. Hotel was extremely clean, quiet and the bed and pillows were comfortable. There are a few food options in walking distance and also a Publix right across the street. They also had a managers appreciation little dinner for all guest, it was really nice. I would definitely stay here again."
A verified traveler stayed at Tru By Hilton Columbia Downtown
Posted 9 hours ago
Other Boutique Hotels
Areas Of South Carolina Midlands
Hotels Near
Hotel Themes
Flights To
Top Trending
Hotels
- All Inclusive Resorts & Hotels in Coastal South Carolina
- Oceanfront Hotels in Coastal South Carolina
- Hotels in Carolina Forest
- Waterpark Hotels & Resorts in Coastal South Carolina
- Hotels with Free Airport Shuttle in Greenville - Spartanburg
- Hotels in Greenville Downtown
- Hotels in Charleston Historic District
- Hotels near Myrtle Beach Convention Center
- Gay Friendly Hotels in Coastal South Carolina
- Spa Resorts & Hotels in Upstate South Carolina
- Hotels near Broadway at the Beach
- Kid Friendly Hotels in Upstate South Carolina
- Hotels in Cherry Grove Beach
- Hotels near Coastal Carolina University
- Hotels in Downtown Myrtle Beach
- Hotels with Free Parking in Charleston Historic District
- Hotels with Kitchenettes in Coastal South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Hotels in West Ashley
- Hotels in Downtown Charleston
- Hotels near Rock Hill Sports & Event Center
- Hotels near Charleston Tanger Outlets
- Hotels near Pier at Garden City
- Pet Friendly Hotels in Cherry Grove Beach