Cheap flights from DSM to GSP (Des Moines Intl. to Greenville-Spartanburg Intl.)

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Cheap Flights from DSM to GSP starting at $163 One Way, $325 Round Trip

Prices starting at $325 for return flights and $163 for one-way flights to Greenville-Spartanburg Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 7 - Sat, Oct 10
DSM
Des Moines
GSP
Greenville
$325 Roundtrip, found 22 hours ago
$325
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Oct 7 from Des Moines to Greenville, returning Sat, Oct 10, priced at $325 found 22 hours ago
Wed, Oct 7 - Sat, Oct 10
DSM
Des Moines
GSP
Greenville
$329 Roundtrip, found 22 hours ago
$329
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Oct 7 from Des Moines to Greenville, returning Sat, Oct 10, priced at $329 found 22 hours ago
Wed, Oct 7 - Sat, Oct 10
DSM
Des Moines
GSP
Greenville
$335 Roundtrip, found 22 hours ago
$335
Roundtrip
found 22 hours ago
Select Southwest Airlines flight, departing Wed, Oct 7 from Des Moines to Greenville, returning Sat, Oct 10, priced at $335 found 22 hours ago
Wed, Oct 7 - Sat, Oct 10
DSM
Des Moines
GSP
Greenville
$335 Roundtrip, found 22 hours ago
$335
Roundtrip
found 22 hours ago
Select Southwest Airlines flight, departing Wed, Oct 7 from Des Moines to Greenville, returning Sat, Oct 10, priced at $335 found 22 hours ago
Wed, Oct 7 - Sat, Oct 10
DSM
Des Moines
GSP
Greenville
$336 Roundtrip, found 22 hours ago
$336
Roundtrip
found 22 hours ago
Select United flight, departing Wed, Oct 7 from Des Moines to Greenville, returning Sat, Oct 10, priced at $336 found 22 hours ago

Hotel Ideas near Greenville-Spartanburg Intl.

Airport Hotels near Greenville-Spartanburg Intl.

Greenville Marriott

Greenville Marriott

4 out of 5
One Parkway E Greenville SC
$122 nightly
The price is $135 total per night from Sep 14 to Sep 15
$135 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.6/10 Excellent! (696 reviews)
"I would have rated everything 5 if it weren’t for renovations being in progress."

Reviewed on Aug 28, 2026

Greenville Marriott
MainStay Suites Greenville Airport

MainStay Suites Greenville Airport

2.5 out of 5
2671 Dry Pocket Rd Greer SC
$71 nightly
The price is $78 total per night from Sep 9 to Sep 10
$78 total
Sep 9 - Sep 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (793 reviews)
"I do not recommend staying here. I had booked two nights and paid online as I always do. Upon arriving the clerk said my card declined for the incidentals charge even though it went through booking the room online with the same card, so I ended up sleeping in a Walmart parking lot. My wife searched ..."

Reviewed on Aug 31, 2026

MainStay Suites Greenville Airport
Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$105 nightly
The price is $116 total per night from Sep 14 to Sep 15
$116 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (884 reviews)
"The lack of near-by dining options was disappointing. The hotel itself was clean and comfortable. Arranging shuttle transport to the airport was very easy."

Reviewed on Aug 31, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Greenville

Courtyard Greenville-Spartanburg by Marriott

Courtyard Greenville-Spartanburg by Marriott

3 out of 5
115 The Pkwy Greer SC
$100 nightly
The price is $110 total per night from Sep 13 to Sep 14
$110 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Courtyard Greenville-Spartanburg by Marriott
Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
1315 W Wade Hampton Blvd Greer SC
$105 nightly
The price is $115 total per night from Sep 27 to Sep 28
$115 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (844 reviews)
"Located in a good area"

Reviewed on Aug 29, 2026

Comfort Inn & Suites Greer - Greenville
MainStay Suites Greenville Airport

MainStay Suites Greenville Airport

2.5 out of 5
2671 Dry Pocket Rd Greer SC
$71 nightly
The price is $78 total per night from Sep 9 to Sep 10
$78 total
Sep 9 - Sep 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (793 reviews)
"I do not recommend staying here. I had booked two nights and paid online as I always do. Upon arriving the clerk said my card declined for the incidentals charge even though it went through booking the room online with the same card, so I ended up sleeping in a Walmart parking lot. My wife searched ..."

Reviewed on Aug 31, 2026

MainStay Suites Greenville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Greenville Hotels With Airport Transportation

Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$105 nightly
The price is $116 total per night from Sep 14 to Sep 15
$116 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (884 reviews)
"The lack of near-by dining options was disappointing. The hotel itself was clean and comfortable. Arranging shuttle transport to the airport was very easy."

Reviewed on Aug 31, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Greenville

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
1315 W Wade Hampton Blvd Greer SC
$105 nightly
The price is $115 total per night from Sep 27 to Sep 28
$115 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (844 reviews)
"Located in a good area"

Reviewed on Aug 29, 2026

Comfort Inn & Suites Greer - Greenville
Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$105 nightly
The price is $116 total per night from Sep 14 to Sep 15
$116 total
Sep 14 - Sep 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (884 reviews)
"The lack of near-by dining options was disappointing. The hotel itself was clean and comfortable. Arranging shuttle transport to the airport was very easy."

Reviewed on Aug 31, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Quality Inn Greer - Greenville

Quality Inn Greer - Greenville

2.5 out of 5
611 W Wade Hampton Blvd Greer SC
$77 nightly
The price is $83 total per night from Sep 11 to Sep 12
$83 total
Sep 11 - Sep 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Quality Inn Greer - Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to GSP Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
GSP Address & GPS
Address:
2000 GPS Drive, Suite 1
Greenville SC, 29651-9202
United States
IATA Code:
GSP
Longitude:
-82.217053
Latitude:
34.890569
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from DSM to GSP?
Unfortunately, nonstop flights aren't an option when traveling from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP). However, there are plenty of carriers that service this route with only one easy stopover, including American Airlines, Delta Air Lines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport to Greenville-Spartanburg Intl. Airport (GSP)?
Make the most of the opportunity to kick back and unwind on the flight from Des Moines to Greenville. The shortest flight time from DSM to Roger Milliken Field is 4 hours and 11 minutes, which gives you loads of time to enjoy a wine or get engrossed in a book.
How many hours flight from Des Moines Intl. Airport to GSP?
Typically, it takes 4 hours and 18 minutes to jet from DSM to GSP. Get through the journey by watching a few movies and browsing a magazine or two. Alternatively, why not catch up on some rest?
What airlines have the most flights from DSM to Greenville-Spartanburg Intl. Airport (GSP)?
Do some people-watching, grab a quick meal, go for a short wander .... Airport stopovers don't have to be a drag! If you're heading from Des Moines to Greenville, there are no direct flights. Get ready for at least one stopover somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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