Cheap flights from DSM to GSP (Des Moines Intl. to Greenville-Spartanburg Intl.)

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Cheap Flights from DSM to GSP starting at $179 One Way, $392 Round Trip

Prices starting at $392 for return flights and $179 for one-way flights to Greenville-Spartanburg Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jun 1 - Mon, Jun 8
DSM
Des Moines
GSP
Greenville
$392 Roundtrip, found 3 days ago
$392
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Mon, Jun 1 from Des Moines to Greenville, returning Mon, Jun 8, priced at $392 found 3 days ago
Mon, Jun 1 - Mon, Jun 8
DSM
Des Moines
GSP
Greenville
$397 Roundtrip, found 3 days ago
$397
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Jun 1 from Des Moines to Greenville, returning Mon, Jun 8, priced at $397 found 3 days ago
Mon, Jun 1 - Mon, Jun 8
DSM
Des Moines
GSP
Greenville
$418 Roundtrip, found 3 days ago
$418
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Mon, Jun 1 from Des Moines to Greenville, returning Mon, Jun 8, priced at $418 found 3 days ago
Fri, Nov 20 - Sun, Nov 29
DSM
Des Moines
GSP
Greenville
$597 Roundtrip, found 13 hours ago
$597
Roundtrip
found 13 hours ago
Select Delta flight, departing Fri, Nov 20 from Des Moines to Greenville, returning Sun, Nov 29, priced at $597 found 13 hours ago
Fri, Nov 20 - Sun, Nov 29
DSM
Des Moines
GSP
Greenville
$627 Roundtrip, found 13 hours ago
$627
Roundtrip
found 13 hours ago
Select Delta flight, departing Fri, Nov 20 from Des Moines to Greenville, returning Sun, Nov 29, priced at $627 found 13 hours ago

Hotel Ideas near Greenville-Spartanburg Intl.

Airport Hotels near Greenville-Spartanburg Intl.

Hampton Inn & Suites Greenville Airport, SC

Hampton Inn & Suites Greenville Airport, SC

2.5 out of 5
128 The Parkway Greenville SC
$101 nightly
The price is $111 total per night from Apr 12 to Apr 13
$111 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,002 reviews)
Two days it was not really that good

Reviewed on Apr 4, 2026

Hampton Inn & Suites Greenville Airport, SC
MainStay Suites Greenville Airport

MainStay Suites Greenville Airport

2.5 out of 5
2671 Dry Pocket Rd Greer SC
$71 nightly
The price is $78 total per night from Apr 12 to Apr 13
$78 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (667 reviews)
Clean and great stay! The perfect location

Reviewed on Mar 30, 2026

MainStay Suites Greenville Airport
Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$114 nightly
The price is $125 total per night from Apr 12 to Apr 13
$125 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (837 reviews)
Breakfast was good. Hotel is a little older and could use some cosmetic upgrades, but everything was clean and comfortable for our family. Would stay here again.

Reviewed on Apr 1, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Greenville

Courtyard Greenville-Spartanburg by Marriott

Courtyard Greenville-Spartanburg by Marriott

3 out of 5
115 The Pkwy Greer SC
$128 nightly
The price is $140 total per night from Apr 6 to Apr 7
$140 total
Apr 6 - Apr 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (650 reviews)
We were traveling from Michigan to South Carolina. I booked online prior to arrival. Upon checking in I was assigned a dirty room not once but twice. The third room was too small for my family and not what I paid for. Took four tries to get us a clean, correct room.

Reviewed on Mar 30, 2026

Courtyard Greenville-Spartanburg by Marriott
Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
1315 W Wade Hampton Blvd Greer SC
$96 nightly
The price is $104 total per night from Apr 12 to Apr 13
$104 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (774 reviews)
Friendly staff. Breakfast had cinnamon roll and regular waffles, as well as eggs, grits, sausage, sausage gravy and biscuits, cereal, yogurt, bagels and muffins

Reviewed on Mar 30, 2026

Comfort Inn & Suites Greer - Greenville
Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$114 nightly
The price is $125 total per night from Apr 12 to Apr 13
$125 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (837 reviews)
Breakfast was good. Hotel is a little older and could use some cosmetic upgrades, but everything was clean and comfortable for our family. Would stay here again.

Reviewed on Apr 1, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Greenville Hotels With Airport Transportation

Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$114 nightly
The price is $125 total per night from Apr 12 to Apr 13
$125 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (837 reviews)
Breakfast was good. Hotel is a little older and could use some cosmetic upgrades, but everything was clean and comfortable for our family. Would stay here again.

Reviewed on Apr 1, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Greenville

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
1315 W Wade Hampton Blvd Greer SC
$96 nightly
The price is $104 total per night from Apr 12 to Apr 13
$104 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (774 reviews)
Friendly staff. Breakfast had cinnamon roll and regular waffles, as well as eggs, grits, sausage, sausage gravy and biscuits, cereal, yogurt, bagels and muffins

Reviewed on Mar 30, 2026

Comfort Inn & Suites Greer - Greenville
Holiday Inn Express & Suites Greenville Airport by IHG

Holiday Inn Express & Suites Greenville Airport by IHG

3.5 out of 5
2681 Dry Pocket Road Greer SC
$114 nightly
The price is $125 total per night from Apr 12 to Apr 13
$125 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (837 reviews)
Breakfast was good. Hotel is a little older and could use some cosmetic upgrades, but everything was clean and comfortable for our family. Would stay here again.

Reviewed on Apr 1, 2026

Holiday Inn Express & Suites Greenville Airport by IHG
Quality Inn Greer - Greenville

Quality Inn Greer - Greenville

2.5 out of 5
611 W Wade Hampton Blvd Greer SC
$77 nightly
The price is $84 total per night from May 3 to May 4
$84 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (342 reviews)
Sheets stunk. Dirty. Good water pressure. Noisy. Apple juice was good.

Reviewed on Apr 4, 2026

Quality Inn Greer - Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to GSP Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
GSP Address & GPS
Address:
2000 GPS Drive, Suite 1
Greenville SC, 29651-9202
United States
IATA Code:
GSP
Longitude:
-82.217053
Latitude:
34.890569
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from DSM to GSP?
Unfortunately, nonstop flights aren't an option when traveling from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP). However, there are plenty of carriers that service this route with only one easy stopover, including American Airlines, Delta Air Lines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport to Greenville-Spartanburg Intl. Airport (GSP)?
Make the most of the opportunity to kick back and unwind on the flight from Des Moines to Greenville. The shortest flight time from DSM to Roger Milliken Field is 4 hours and 11 minutes, which gives you loads of time to enjoy a wine or get engrossed in a book.
How many hours flight from Des Moines Intl. Airport to GSP?
Typically, it takes 4 hours and 18 minutes to jet from DSM to GSP. Get through the journey by watching a few movies and browsing a magazine or two. Alternatively, why not catch up on some rest?
What airlines have the most flights from DSM to Greenville-Spartanburg Intl. Airport (GSP)?
Do some people-watching, grab a quick meal, go for a short wander .... Airport stopovers don't have to be a drag! If you're heading from Des Moines to Greenville, there are no direct flights. Get ready for at least one stopover somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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