
$120 Cheap flight deals from Des Moines (DSM) to Panama City Beach (DSI)
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Airfares from $120 One Way, $294 Round Trip from Des Moines to Panama City Beach
Prices starting at $294 for return flights and $120 for one-way flights to Panama City Beach were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Panama City Beach economy flight packages

The Henderson Beach Resort & Spa
Jul 29 - Aug 1
Des Moines (DSM) to Fort Walton Beach (VPS)
Fort Walton Beach (VPS) to Des Moines (DSM)
Reviewed on May 28, 2026

Near Inlet Beach Access&lake Powell, Pool, Patio Lounge G'day 30A by Avantstay
Jul 29 - Aug 1
Des Moines (DSM) to Panama City (ECP)
Panama City (ECP) to Des Moines (DSM)

Emerald Breeze by Avantstay Shared Pool + Tennis Court + Balcony Dining + Near Beach and Harbor Boardwalk
Jul 29 - Aug 1
Des Moines (DSM) to Fort Walton Beach (VPS)
Fort Walton Beach (VPS) to Des Moines (DSM)
More About Flying To Panama City Beach from Des Moines
Route Information for Flights from Des Moines to Panama City Beach
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | DSI |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Panama City Beach
If you feel you cannot afford the costs involved to your dream trip to a local or international destination happen, think again! Orbitz gives you incredible deals on flights from Des Moines to Panama City Beach. Now you can book guaranteed low fares for Des Moines to Panama City Beach flights and plan your trip with confidence.
Great deals on flights from Des Moines to Panama City Beach
Cheap airfares on Des Moines to Panama City Beach flights allow you to stick to your budget and still have a great trip. We give you guaranteed low prices and make it easy to research and book discount flights using our website. Additionally, you can add your frequent flyer numbers to your Orbitz account profile, and this information will automatically be included on all your future reservations for qualified flights from Des Moines to Panama City Beach.
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Des Moines to Panama City Beach flights at discounted rates
Finding flights at the right prices can be difficult if you are not sure where to look. Don’t ruin your trip by spending more on your flights than your budget allows. Orbitz gives you guaranteed low fares on Des Moines to Panama City Beach flights and amazing discount offers on car rentals, hotels, and even fun activities in your destination. Your dream trip is more affordable than ever with Orbitz.
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Flights from Des Moines
- Des Moines to Dallas
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.


