
$79 Cheap flight deals from Des Moines (DSM) to St. Louis (STL)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
Airfares from $79 One Way, $154 Round Trip from Des Moines to St. Louis
Prices starting at $154 for return flights and $79 for one-way flights to St. Louis were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
St. Louis economy flight packages


The Wildwood Hotel
Nov 24 - Dec 1
Des Moines (DSM) to St. Louis (STL)
Reviewed on Oct 16, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Nov 24 - Dec 1
Des Moines (DSM) to St. Louis (STL)
Reviewed on Sep 9, 2024
More About Flying To St. Louis from Des Moines
Route Information for Flights from Des Moines to St. Louis
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | STL |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Finding Flights from Des Moines to St Louis
Cheap Flights from Des Moines
Locating cheap flights from Des Moines is easy with the assistance of Orbitz.com. Des Moines International Airport (DSM) offers a wide range of affordable flights from top airline providers. This airport offers flights with United Airlines, Delta Airlines, Allegiant Airlines, US Airways and more. Des Moines International is located in Des Moines, IA at 5800 Fleur Drive and is approximately three miles from the downtown area of the city.
Airport Parking Information
DSM provides a variety of airport parking choices to its passengers. These choices include short-term, long-term and economy parking. Short-term rates start at $1per half-hour, with a $24-per-day maximum. Long-term rates start at $2 per hour, with a $12-per-day maximum. Economy rates at DSM start at $2 per hour, with a $5-per-day maximum.
DSM Transportation Information
Passenger transportation options include shuttle buses, car rentals, limousines, taxis and public transit. Bus transportation is offered by Greyhound, Jefferson Bus Lines and Trailways Bus System. Other options can be found through Alamo Car Rental, Budget Rent A Car, Capitol Cab Company and C & C Limousine Services, among others.
Restaurants at Des Moines International Airport
Travelers can choose from a variety of restaurants at DSM, many of which can be found at the Landside Food Court. This dining area is open from 4:30 am to 7:30 pm daily, and is home to a Pizza Hut Express and an American Grill restaurant, among others. Let Orbitz.com help you book cheap flights from Des Moines and learn about your airport options.
Lambert-St. Louis International Airport
Allow Orbitz.com to help you book flights to St. Louis. Lambert-St.Louis International Airport is located 10 miles northwest of St. Louis. Over 13 million passengers pass through the airport each year. It is the largest airport in the state of Missouri and services 255 daily departures to over 90 cities, domestically and internationally. Southwest Airlines is based out of Lambert, and Air Canada, Alaska Airlines, Cape Air, Delta and American Airlines all have major hubs at Lambert. You can use Orbitz.com to book bargain tickets on your next trip to the St. Louis area.
St. Louis International Airport Transportation
St. Louis International Airport offers a variety of transportation services for the busy traveler. Shuttle services, rental cars, and public transportation are available at the airport. Go Best Express Airport Shuttle is a popular shuttle service for group transportation. One-way fares start at $17. The MetroLink is St. Louis' rail system and operates 37 stations throughout the city. One-way fares cost $2.
St. Louis Weather
St. Louis has distinct seasons. Summers are hot, and temperatures can get as high as 90 degrees F. Spring is usually a rainy season for St. Louis, so it is best to pack an umbrella for your trip during March, April and May. Fall is usually mild, with temperatures averaging 57 degrees F. Winters can be freezing, with temperature falling to 20 degrees F. Bring a warm coat and boots during winter trips to St. Louis.
Popular Attractions in St. Louis
St. Louis offers a variety of attractions for visitors. Some popular attractions include the famous Gateway Arch, Six Flags of St. Louis, the Saint Louis Zoo and Forest Park. St. Louis is also home to several theaters, such as the Ferrara Theatre, Fox Theatre, and Grand Center. Some popular museums include the St. Louis Children's Museum and the Beall Mansion Museums. Book flights to St. Louis with the help of Orbitz.com to visit these popular attractions.
Frequently asked questions
- Flights to St. Louis
- Flights from Des Moines
- Des Moines Airports
- St. Louis Airports
- Airlines Operating
- Flights To
Flights to St. Louis
- Dallas to St. Louis
- New York to St. Louis
- Houston to St. Louis
- Chicago to St. Louis
- Las Vegas to St. Louis
- Los Angeles to St. Louis
- Phoenix to St. Louis
- Orlando to St. Louis
- Detroit to St. Louis
- Kansas City to St. Louis
- New Orleans to St. Louis
- San Francisco to St. Louis
- Montreal to St. Louis
- Atlantic City to St. Louis
- Killeen to St. Louis
- Anchorage to St. Louis
- Beijing to St. Louis
- Buenos Aires to St. Louis
- Berlin to St. Louis
- Madrid to St. Louis
Flights from Des Moines
- Des Moines to Houston
- Des Moines to Dallas
- Des Moines to Atlanta
- Des Moines to Phoenix
- Des Moines to Orlando
- Des Moines to Seattle
- Des Moines to Chicago
- Des Moines to Los Angeles
- Des Moines to New York
- Des Moines to Charlotte
- Des Moines to Detroit
- Des Moines to Washington
- Des Moines to London
- Des Moines to New Orleans
- Des Moines to Sacramento
- Des Moines to Toronto
- Des Moines to San Francisco
- Des Moines to Rome
- Des Moines to Paris
- Des Moines to Hartford
Des Moines Airports
St. Louis Airports
More Destinations
- Flights from Duluth to St. Charles
- Flights from Dublin to St. Charles
- Flights from Las Vegas to St. Charles
- Flights from Memphis to St. Charles
- Flights from Nairobi to St. Charles
- Flights from Fort Lauderdale to St. Charles
- Flights from Newark to St. Charles
- Flights from Oakland to St. Charles
- Flights from Tulsa to St. Charles
- Flights from Midland to St. Charles
- Flights from Spokane to St. Charles
- Flights from Dayton to St. Charles
- Flights from Fresno to St. Charles
- Flights from Albany to St. Charles
- Flights from Lafayette to St. Charles
- Flights from State College to St. Charles
- Flights from Boston to Kirkwood
- Flights from Chicago to Kirkwood
- Flights from Kansas City to Kirkwood
- Flights from Memphis to Kirkwood
- Flights from Miami to Kirkwood
- Flights from Minneapolis - St. Paul to Kirkwood
- Flights from New York to Kirkwood
- Flights from Portland to Kirkwood
- Flights from Vancouver to Kirkwood
- Flights from Washington to Kirkwood
- Flights from Traverse City to Kirkwood
- Flights from Hilton Head Island to Kirkwood
- Flights from Richmond to Kirkwood
- Flights from Colorado Springs to Kirkwood
- Flights from Austin to Brentwood
- Flights from Charlotte to Brentwood
- Flights from Dallas to Brentwood
- Flights from Detroit to Brentwood
- Flights from Miami to Brentwood
- Flights from Nairobi to Brentwood
- Flights from New York to Brentwood
- Flights from Salt Lake City to Brentwood
- Flights from Sacramento to Brentwood
- Flights from Myrtle Beach to Brentwood
- Flights from Burlington to Brentwood
- Flights from South Bend to Brentwood
- Flights from Fresno to Brentwood
- Flights from Tampa to Brentwood
- Flights from Elmira to Maryland Heights
- Flights from Bangkok to Maryland Heights
- Flights from Portland to Maryland Heights
- Flights from Raleigh to Maryland Heights
- Flights from Washington to Maryland Heights
- Flights from Venice to Maryland Heights
- Flights from Oklahoma City to Maryland Heights
- Flights from Baton Rouge to Maryland Heights
- Flights from Bogotá to Florissant
- Flights from Brussels to Florissant
- Flights from Cleveland to Florissant
- Flights from Las Vegas to Florissant
- Flights from Memphis to Florissant
- Flights from Miami to Florissant
- Flights from Portland to Florissant
- Flights from Toronto to Florissant
- Flights from Sacramento to Florissant
- Flights from Oakland to Florissant
- Flights from Madison to Florissant
- Flights from Montgomery to Florissant
- Flights from Casper to Florissant
- Flights from Elmira to Chesterfield
- Flights from San Francisco to Chesterfield
- Flights from St. Louis to Chesterfield
- Flights from Cologne to Chesterfield
- Flights from Londonderry to Chesterfield
- Flights from Milos to Chesterfield
- Flights from Monroe to Chesterfield
- Flights from Newquay to Chesterfield
- Flights from Bloomington to Chesterfield
- Flights from Manchester to Chesterfield
- Flights from Eugene to Chesterfield
- Flights from Colorado Springs to Chesterfield
- Flights from Princeton to Chesterfield
- Flights from Svedala to Chesterfield
- Flights from Reykjavik to Chesterfield
- Flights from Portsmouth to Chesterfield
- Flights from Fort Smith to Chesterfield
- Flights from Kitakyushu to Chesterfield
- Flights from Legazpi to Chesterfield
- Flights from Walla Walla to Chesterfield
- Flights from Castrillon to Chesterfield
- Flights from Columbia to Chesterfield
- Flights from Dhaka to Chesterfield
- Flights from Austin (AUS) to St. Louis (STL)
- Flights from Kadapa (CDP) to St. Louis (STL)
- Flights from Cleveland (CLE) to St. Louis (STL)
- Flights from Washington (DCA) to St. Louis (STL)
- Flights from Denver (DEN) to St. Louis (STL)
- Flights from New York (LGA) to St. Louis (STL)
- Flights from Memphis (MEM) to St. Louis (STL)
- Flights from Phoenix (PHX) to St. Louis (STL)
- Flights from Pittsburgh (PIT) to St. Louis (STL)
- Flights from Reading (RDG) to St. Louis (STL)
- Flights from Tampa (TPA) to St. Louis (STL)
- Flights from Sault Ste. Marie (YAM) to St. Louis (STL)
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
