Cheap flights from FSD to EYW (Sioux Falls Regional to Key West Intl.)

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Cheap Flights from FSD to EYW starting at $374 One Way, $479 Round Trip

Prices starting at $479 for return flights and $374 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Dec 13 - Wed, Dec 23
FSD
Sioux Falls
EYW
Key West
$479 Roundtrip, found 6 days ago
$479
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Dec 13 from Sioux Falls to Key West, returning Wed, Dec 23, priced at $479 found 6 days ago
Sun, Dec 13 - Wed, Dec 23
FSD
Sioux Falls
EYW
Key West
$555 Roundtrip, found 6 days ago
$555
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Dec 13 from Sioux Falls to Key West, returning Wed, Dec 23, priced at $555 found 6 days ago
Sun, Dec 13 - Wed, Dec 23
FSD
Sioux Falls
EYW
Key West
$559 Roundtrip, found 6 days ago
$559
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Dec 13 from Sioux Falls to Key West, returning Wed, Dec 23, priced at $559 found 6 days ago
Sun, Dec 13 - Wed, Dec 23
FSD
Sioux Falls
EYW
Key West
$559 Roundtrip, found 6 days ago
$559
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Dec 13 from Sioux Falls to Key West, returning Wed, Dec 23, priced at $559 found 6 days ago
Sun, Dec 13 - Wed, Dec 23
FSD
Sioux Falls
EYW
Key West
$579 Roundtrip, found 6 days ago
$579
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Dec 13 from Sioux Falls to Key West, returning Wed, Dec 23, priced at $579 found 6 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$295 nightly
The price is $332 total per night from Aug 13 to Aug 14
$332 total
Aug 13 - Aug 14
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,199 reviews)
"Fantastic property!!! Very well maintained!!!"

Reviewed on Jul 17, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$161 nightly
The price is $181 total per night from Aug 11 to Aug 12
$181 total
Aug 11 - Aug 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,443 reviews)
"Clean room! Beautiful view!"

Reviewed on Jul 18, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$165 nightly
The price is $186 total per night from Aug 9 to Aug 10
$186 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,049 reviews)
"H"

Reviewed on Jul 18, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$202 nightly
The price is $227 total per night from Aug 18 to Aug 19
$227 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (2,352 reviews)
"Keep looking and do not waste your money. The first room we were put into had a mini fridge on the floor that had leaked all over and made a small puddle/stream. Elevator in that building broken. Then they switched our room and did give us an upgrade, but the elevators didn’t work in our building ..."

Reviewed on Jul 19, 2026

Beachside Resort & Residences
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$210 nightly
The price is $237 total per night from Aug 18 to Aug 19
$237 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,439 reviews)
"Nice to be near the beach. The pool was great until they allowed people from a cruise ship take over the pool and ruined our time there. It became overcrowded and noisy. We had to change rooms because the fan didn’t work and our room’s bathroom was tiny, only one person could fit in it at a time. ..."

Reviewed on Jul 19, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$171 nightly
The price is $192 total per night from Aug 18 to Aug 19
$192 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,552 reviews)
"It’s a great hotel for families"

Reviewed on Jul 19, 2026

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$165 nightly
The price is $186 total per night from Aug 9 to Aug 10
$186 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,049 reviews)
"H"

Reviewed on Jul 18, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$161 nightly
The price is $181 total per night from Aug 11 to Aug 12
$181 total
Aug 11 - Aug 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,443 reviews)
"Clean room! Beautiful view!"

Reviewed on Jul 18, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$173 nightly
The price is $195 total per night from Aug 17 to Aug 18
$195 total
Aug 17 - Aug 18
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$155 nightly
The price is $175 total per night from Aug 16 to Aug 17
$175 total
Aug 16 - Aug 17
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,359 reviews)
"The bathroom had no air or heat or exhaust fan."

Reviewed on Jul 19, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$120 nightly
The price is $135 total per night from Jul 22 to Jul 23
$135 total
Jul 22 - Jul 23
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
"Affordable"

Reviewed on Jul 10, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$123 nightly
The price is $136 total per night from Jul 30 to Jul 31
$136 total
Jul 30 - Jul 31
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$210 nightly
The price is $237 total per night from Aug 18 to Aug 19
$237 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,439 reviews)
"Nice to be near the beach. The pool was great until they allowed people from a cruise ship take over the pool and ruined our time there. It became overcrowded and noisy. We had to change rooms because the fan didn’t work and our room’s bathroom was tiny, only one person could fit in it at a time. ..."

Reviewed on Jul 19, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$171 nightly
The price is $192 total per night from Aug 18 to Aug 19
$192 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,552 reviews)

Families like: Outdoor pools, playground, miniature golf, game room

Travelers say...
"It’s a great hotel for families"

Reviewed on Jul 19, 2026

Blue Flamingo Resort Key West
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$189 nightly
The price is $213 total per night from Aug 2 to Aug 3
$213 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,851 reviews)
"very nice place to go on family vacation, totally recommend"

Reviewed on Jul 19, 2026

Oceans Edge Key West Resort, Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

FSD to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
FSD Address & GPS
Address:
2801 Jaycee Lane
Sioux Falls SD, 57104
United States
IATA Code:
FSD
Longitude:
-96.741849
Latitude:
43.58201
Time Zone:
America/Chicago
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Joe Foss Field to EYW?
There are no direct flights on this route. But American Airlines, Delta Air Lines and Qatar Airways will fly you from Joe Foss Field to Key West Intl. Airport (EYW) with just one stopover.
What is the shortest flight from Joe Foss Field to EYW?
From Sioux Falls, the thrilling sights and sounds of Key West are around 4 hours and 58 minutes away. Choose your favorite seat, or perhaps even upgrade to one with more legroom, and fly to your destination in comfort.
How many hours flight from Joe Foss Field to Key West Intl. Airport?
On a normal day, the trip from Joe Foss Field to Key West Intl. Airport (EYW) takes 5 hours and 3 minutes. If you're eager to be as comfortable as possible, consider upgrading your seat using miles or cash.
What airlines have the most flights from Joe Foss Field to Key West Intl. Airport?
If you're hoping to book with an airline that advertises direct flights from Sioux Falls Regional Airport (FSD) to Key West Intl. Airport, it's not going to happen. You'll need to book a flight with at least one stopover to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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