$151 Cheap flight deals from Greenville - Spartanburg (GSP) to O'Fallon (STL)

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Airfares from $151 One Way, $335 Round Trip from Greenville - Spartanburg to O'Fallon

Prices starting at $335 for return flights and $151 for one-way flights to O'Fallon were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jun 5 - Mon, Jun 8
AVL
Asheville
STL
St. Louis
$335 Roundtrip, found 16 hours ago
$335
Roundtrip
found 16 hours ago
Select Delta flight, departing Fri, Jun 5 from Asheville to St. Louis, returning Mon, Jun 8, priced at $335 found 16 hours ago
Fri, Jun 5 - Mon, Jun 8
AVL
Asheville
STL
St. Louis
$339 Roundtrip, found 16 hours ago
$339
Roundtrip
found 16 hours ago
Select United flight, departing Fri, Jun 5 from Asheville to St. Louis, returning Mon, Jun 8, priced at $339 found 16 hours ago
Mon, Jun 22 - Tue, Jun 23
GSP
Greenville
STL
St. Louis
$352 Roundtrip, found 20 hours ago
$352
Roundtrip
found 20 hours ago
Select Southwest Airlines flight, departing Mon, Jun 22 from Greenville to St. Louis, returning Tue, Jun 23, priced at $352 found 20 hours ago
Fri, Jun 5 - Mon, Jun 8
AVL
Asheville
STL
St. Louis
$356 Roundtrip, found 16 hours ago
$356
Roundtrip
found 16 hours ago
Select Delta flight, departing Fri, Jun 5 from Asheville to St. Louis, returning Mon, Jun 8, priced at $356 found 16 hours ago
Mon, Jun 22 - Tue, Jun 23
GSP
Greenville
STL
St. Louis
$357 Roundtrip, found 20 hours ago
$357
Roundtrip
found 20 hours ago
Select Southwest Airlines flight, departing Mon, Jun 22 from Greenville to St. Louis, returning Tue, Jun 23, priced at $357 found 20 hours ago

O'Fallon economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
3.5-star property

The Wildwood Hotel

9.2/10 Wonderful! (1,627 reviews)

Jun 1 - Jun 3

2 night stay

Greenville (GSP) to St. Louis (STL)

Southwest Airlines • Non-stop roundtrip • Coach
Price was $568, price is now $403 per person
$403
per person
found 1 day ago
This hotel was fantastic! Check in was easy with friendly staff, the room was beautiful and well appointed. Breakfast was advertised as a Continental, however they had hot options as well, which was great. Every staff member we saw in the hotel said hi and was friendly. I would definitely stay here again!

Reviewed on Oct 16, 2025

Spacious 3-Bedroom with King Bed
4.0-star property

Spacious 3-Bedroom with King Bed

8.8/10 Excellent! (11 reviews)

Jun 4 - Jun 6

2 night stay

Greenville (GSP) to St. Louis (STL)

American Airlines • Non-stop • Coach

St. Louis (STL) to Greenville (GSP)

Southwest Airlines • Non-stop • Coach
Price was $865, price is now $702 per person
$702
per person
found 1 day ago
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
4.0-star property

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

8.8/10 Excellent! (1,049 reviews)

May 31 - Jun 2

2 night stay

Greenville (GSP) to St. Louis (STL)

Southwest Airlines • Non-stop roundtrip • Coach
Price was $516, price is now $433 per person
$433
per person
found 1 day ago
Perfect location for stay after event at Powell Theater. Roof top bar was nice although a little pricey. Room was unique, clean, and comfortable. Parking is additional.

Reviewed on Jan 18, 2026

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More About Flying To O'Fallon from Greenville - Spartanburg

Route Information for Flights from Greenville - Spartanburg to O'Fallon

Origin Airport IATA Code
GSP
Destination Airport IATA Code
STL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Greenville - Spartanburg to O'Fallon

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.