$145 Cheap flight deals from Knoxville (TYS) to Key West (EYW)

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Airfares from $145 One Way, $249 Round Trip from Knoxville to Key West

Prices starting at $249 for return flights and $145 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Oct 21 - Wed, Oct 29
TYS
Knoxville
EYW
Key West
$249 Roundtrip, found 4 days ago
$249
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Oct 21 from Knoxville to Key West, returning Wed, Oct 29, priced at $249 found 4 days ago
Fri, Oct 24 - Wed, Oct 29
TYS
Knoxville
EYW
Key West
$249 Roundtrip, found 4 days ago
$249
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Oct 24 from Knoxville to Key West, returning Wed, Oct 29, priced at $249 found 4 days ago
Fri, Sep 5 - Mon, Sep 8
TYS
Knoxville
EYW
Key West
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Sep 5 from Knoxville to Key West, returning Mon, Sep 8, priced at $251 found 6 days ago
Wed, Oct 22 - Wed, Oct 29
TYS
Knoxville
EYW
Key West
$266 Roundtrip, found 4 days ago
$266
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Oct 22 from Knoxville to Key West, returning Wed, Oct 29, priced at $266 found 4 days ago
Sat, Sep 13 - Wed, Sep 17
TYS
Knoxville
EYW
Key West
$268 Roundtrip, found 5 days ago
$268
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Sep 13 from Knoxville to Key West, returning Wed, Sep 17, priced at $268 found 5 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

8.8/10 Excellent! (1,668 reviews)

Sep 11 - Sep 17

6 night stay

Knoxville (TYS) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
Great area for the cost. Very clean and inviting. Room had a water harbor view which was nice.

Reviewed on Jul 12, 2025

Orchid Key Inn - Adults Only
3.5-star property

Orchid Key Inn - Adults Only

9.8/10 Exceptional! (1,005 reviews)

Sep 11 - Sep 17

6 night stay

Knoxville (TYS) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
Great place. Very cool retro motel that’s been renovated. Room was a little small but very comfortable and clean. There’s a nice bar with great cocktails. Staff are friendly and attentive. The location was great. Central to everything and very walkable to most of the popular sites.

Reviewed on Jan 20, 2025

Hyatt Vacation Club at Beach House, Key West
3.5-star property

Hyatt Vacation Club at Beach House, Key West

9.2/10 Wonderful! (1,003 reviews)

Sep 11 - Sep 17

6 night stay

Knoxville (TYS) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
The hotel was very nice. The bathroom in the primary sweet was amazing. Suzy at the tiki hut on the property was great!

Reviewed on May 16, 2025

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More About Flying To Key West from Knoxville

Route Information for Flights from Knoxville to Key West

Origin Airport IATA Code
TYS
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Knoxville to Key West

Grab great fares on Knoxville to Key West flights with Orbitz, your #1 source for discount international and domestic air tickets. Our cutting-edge mobile tools and great online search functionality make booking your next budget trip a breeze.

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Find Your Knoxville to Key West Flights, Car, and Hotel in One Place

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Earn Miles for Flights From Knoxville to Key West

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Frequently asked questions

Am I able to catch a flight from Knoxville to Key West now?
If you're agonizing over quarantine requirements and travel restrictions when catching a flight from Knoxville to Key West, check out our Covid-19 Travel Advisor.
What is the shortest flight from Knoxville to Key West?
It can be as a short and sweet as 2 hours and 36 minutes. If you're of the opinion that your vacation hours should be spent 'vacationing' instead of flying, you'll enjoy the trip from TYS to Key West Intl. Airport.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.