
$111 Cheap flight deals from Des Moines (DSM) to South Carolina Midlands (CAE)
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This Weekend's Flight Deals from Des Moines to South Carolina Midlands
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $111 One Way, $269 Round Trip from Des Moines to South Carolina Midlands
Prices starting at $269 for return flights and $111 for one-way flights to South Carolina Midlands were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
South Carolina Midlands economy flight packages

Grand Atlantic Ocean Resort
Mar 14 - Mar 17
Des Moines (DSM) to Myrtle Beach (MYR)
Myrtle Beach (MYR) to Des Moines (DSM)
Reviewed on Sep 2, 2025

The Ellie Beach Resort Myrtle Beach, Tapestry By Hilton
Mar 14 - Mar 17
Des Moines (DSM) to Myrtle Beach (MYR)
Myrtle Beach (MYR) to Des Moines (DSM)
Reviewed on Sep 19, 2025

Club Wyndham at the Cottages
Mar 14 - Mar 17
Des Moines (DSM) to Myrtle Beach (MYR)
Myrtle Beach (MYR) to Des Moines (DSM)
More About Flying To South Carolina Midlands from Des Moines
Route Information for Flights from Des Moines to South Carolina Midlands
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | CAE |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to South Carolina Midlands
When you’re searching for Des Moines to South Carolina Midlands flights for your family vacation, check out the guaranteed low prices at Orbitz. If you are looking for the best prices on hotels too, you’ll be sure to find great deals to suit your budget. You’ll also benefit from the following features:
Suitable Schedules
Orbitz simplifies the process of finding and booking budget flights from Des Moines to South Carolina Midlands. Since we monitor hundreds of flight fares, you can compare several flights from a range of different airlines to find the best fares and most suitable departure and arrival times. Mix and match your departure and return flight for even more discounts and travel flexibility.
Mobile Apps
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Flight Alerts
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Miles and Points
If you travel regularly, you can still earn miles and points when you book qualifying Des Moines to South Carolina Midlands flights. Enter your frequent flyer number with your reservation to see the miles rack up.
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Des Moines Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

