$133 Cheap flight deals from Des Moines (DSM) to South Carolina Midlands (CAE)

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This Weekend's Flight Deals from Des Moines to South Carolina Midlands

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 11 - Sun, Sep 13
DSM
Des Moines Intl.
CLT
Charlotte-Douglas Intl.
$490 Roundtrip, found 3 days ago
$490
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Sep 11 from Des Moines Intl. to Charlotte-Douglas Intl., returning Sun, Sep 13, priced at $490 found 3 days ago

Airfares from $133 One Way, $352 Round Trip from Des Moines to South Carolina Midlands

Prices starting at $352 for return flights and $133 for one-way flights to South Carolina Midlands were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 24 - Mon, Sep 28
DSM
Des Moines
CLT
Charlotte
$352 Roundtrip, found 5 days ago
$352
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 24 from Des Moines to Charlotte, returning Mon, Sep 28, priced at $352 found 5 days ago
Fri, Sep 25 - Tue, Sep 29
DSM
Des Moines
CLT
Charlotte
$358 Roundtrip, found 5 days ago
$358
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Fri, Sep 25 from Des Moines to Charlotte, returning Tue, Sep 29, priced at $358 found 5 days ago
Mon, Sep 14 - Wed, Sep 16
DSM
Des Moines
CLT
Charlotte
$364 Roundtrip, found 5 days ago
$364
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Mon, Sep 14 from Des Moines to Charlotte, returning Wed, Sep 16, priced at $364 found 5 days ago
Sat, Dec 5 - Sat, Dec 12
DSM
Des Moines
CLT
Charlotte
$388 Roundtrip, found 5 days ago
$388
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Dec 5 from Des Moines to Charlotte, returning Sat, Dec 12, priced at $388 found 5 days ago
Thu, Sep 24 - Mon, Sep 28
DSM
Des Moines
CLT
Charlotte
$392 Roundtrip, found 5 days ago
$392
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 24 from Des Moines to Charlotte, returning Mon, Sep 28, priced at $392 found 5 days ago

South Carolina Midlands economy flight packages

Price found within the past 48 hours. Click for updated prices.
Westgate Myrtle Beach Oceanfront Resort
3.5-star property

Westgate Myrtle Beach Oceanfront Resort

8.6/10 Excellent! (1,361 reviews)

Oct 20 - Oct 24

4 night stay

Des Moines (DSM) to Myrtle Beach (MYR)

American Airlines • Non-stop • Coach

Myrtle Beach (MYR) to Des Moines (DSM)

Southwest Airlines • Non-stop • Coach
Price was $885, price is now $508 per person
$508
per person
found 11 hours ago

Grand Atlantic Ocean Resort
3.5-star property

Grand Atlantic Ocean Resort

8.8/10 Excellent! (1,253 reviews)

Oct 20 - Oct 24

4 night stay

Des Moines (DSM) to Myrtle Beach (MYR)

American Airlines • Non-stop • Coach

Myrtle Beach (MYR) to Des Moines (DSM)

Southwest Airlines • Non-stop • Coach
Price was $859, price is now $709 per person
$709
per person
found 11 hours ago
Everything was wonderful. Excellent will definitely stay again

Reviewed on Sep 6, 2026

Caribbean Resort & Villas
3.0-star property

Caribbean Resort & Villas

7.8/10 Good! (1,131 reviews)

Oct 20 - Oct 24

4 night stay

Des Moines (DSM) to Myrtle Beach (MYR)

American Airlines • Non-stop • Coach

Myrtle Beach (MYR) to Des Moines (DSM)

Southwest Airlines • Non-stop • Coach
Price was $700, price is now $583 per person
$583
per person
found 11 hours ago

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More About Flying To South Carolina Midlands from Des Moines

Route Information for Flights from Des Moines to South Carolina Midlands

Origin Airport IATA Code
DSM
Destination Airport IATA Code
CAE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Des Moines to South Carolina Midlands

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.