
$34 Cheap flight deals from Des Moines (DSM) to Lafayette (DEN)
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This Weekend's Flight Deals from Des Moines to Lafayette
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $34 One Way, $67 Round Trip from Des Moines to Lafayette
Prices starting at $67 for return flights and $34 for one-way flights to Lafayette were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Lafayette economy flight packages

Patterson Inn
Feb 17 - Feb 23
Des Moines (DSM) to Denver (DEN)
Denver (DEN) to Des Moines (DSM)
Reviewed on Sep 28, 2025

Hyatt Regency Denver at Colorado Convention Center
Feb 17 - Feb 23
Des Moines (DSM) to Denver (DEN)
Denver (DEN) to Des Moines (DSM)
Reviewed on Jul 25, 2025

Hilton Denver City Center
Feb 17 - Feb 23
Des Moines (DSM) to Denver (DEN)
Denver (DEN) to Des Moines (DSM)
Reviewed on Dec 16, 2025
More About Flying To Lafayette from Des Moines
Route Information for Flights from Des Moines to Lafayette
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | DEN |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Lafayette
Orbitz guarantees you low prices on flights from Des Moines to Lafayette. In addition to low fares on Des Moines to Lafayette flights, Orbitz offers fantastic savings on hotels, cruises, vacation packages, and more.
Earn Miles While Saving
Besides helping you fly for the lowest fares, Orbitz lets you earn miles for your frequent flyer program for certain flights from Des Moines to Lafayette. If you are a member of the frequent flyer or loyalty program offered by the airline you booked through Orbitz or a partner airline’s, simply add your frequent flyer number to your Orbitz reservation to get credit for your Des Moines to Lafayette flights.
Travel Planning Made Easy
We help take some of the anxiety out of your Des Moines to Lafayette flights with free flight alerts. We will let you know of flight changes and delays to your flights from Des Moines to Lafayette by email, voicemail, or text messages to your mobile phone. Alerts can also be sent to up to six other contacts to keep family and business teams informed.
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Flights from Des Moines
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Des Moines Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
