$266 Cheap flight deals from Charleston (CHS) to Panama City (PTY)

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Airfares from $266 One Way, $576 Round Trip from Charleston to Panama City

Prices starting at $576 for return flights and $266 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Aug 24 - Wed, Aug 26
CHS
Charleston
PTY
Panama City
$576 Roundtrip, found 1 day ago
$576
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Mon, Aug 24 from Charleston to Panama City, returning Wed, Aug 26, priced at $576 found 1 day ago
Thu, Sep 24 - Tue, Sep 29
CHS
Charleston
PTY
Panama City
$578 Roundtrip, found 4 days ago
$578
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Thu, Sep 24 from Charleston to Panama City, returning Tue, Sep 29, priced at $578 found 4 days ago
Mon, Aug 24 - Wed, Aug 26
CHS
Charleston
PTY
Panama City
$585 Roundtrip, found 1 day ago
$585
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Mon, Aug 24 from Charleston to Panama City, returning Wed, Aug 26, priced at $585 found 1 day ago
Thu, Sep 24 - Tue, Sep 29
CHS
Charleston
PTY
Panama City
$588 Roundtrip, found 4 days ago
$588
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Thu, Sep 24 from Charleston to Panama City, returning Tue, Sep 29, priced at $588 found 4 days ago
Tue, Sep 1 - Wed, Sep 30
CHS
Charleston
PTY
Panama City
$589 Roundtrip, found 3 days ago
$589
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Sep 1 from Charleston to Panama City, returning Wed, Sep 30, priced at $589 found 3 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (5,778 reviews)

Sep 24 - Sep 27

3 night stay

Charleston (CHS) to Panama City (PTY)

American Airlines • Non-stop • Coach

Panama City (PTY) to Charleston (CHS)

Avianca • Non-stop • Coach
Price was $973, price is now $797 per person
$797
per person
found 1 day ago
The last night was a party until 3 am . We could not sleep. The main area small like wet clothes all the time . The breakfast was great . Few servings personnel in the swimming area need re training how to treat visitors. I won’t come back

Reviewed on Aug 6, 2026

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9.2/10 Wonderful! (1,000 reviews)

Sep 24 - Sep 27

3 night stay

Charleston (CHS) to Panama City (PTY)

American Airlines • Non-stop • Coach

Panama City (PTY) to Charleston (CHS)

Avianca • Non-stop • Coach
Price was $1,283, price is now $851 per person
$851
per person
found 1 day ago
The hotel is as the name indicated, in the center of old town. The location is fantastic. Very convenient. However, as some of the reviews had mentioned, they have live music in the lobby all day until 11pm. I was aware of this and requested that they give us a quiet room. However, we were given a room with windows facing the atrium and were subjected to the music all day. It was not too loud but was quite annoying if you want quietness. Add to this, it was on the 4th floor and next to one of the restaurant/bar and there were noises coming from it until late. The room was 426 so to other travelers, avoid this room. The bathroom shower was poorly designed and the floor was flooded after every shower. We had to use tons to towels to mop up the water. Not sure why we were given such a lousy room even though the hotel didn’t seem fully booked. The only reason I didn’t request for another room because my husband has unpacked all his stuffs and didn’t want to move. Are Expedia customers treated worse or something? The positives: the room was reasonably spacious. Beddings were comfortable. Roof top pool was nice although it is rather of small and it could use some fixing up. The staff was courteous and breakfast was decent. Had it not for the noisy room, it would have been a nice stay. For this reason, I don’t think we’ll stay here again in the future since noisy room is a deal breaker for me.

Reviewed on Aug 6, 2026

Hyatt Regency Panama City
5.0-star property

Hyatt Regency Panama City

9.6/10 Exceptional! (386 reviews)

Sep 24 - Sep 27

3 night stay

Charleston (CHS) to Panama City (PTY)

American Airlines • Non-stop • Coach

Panama City (PTY) to Charleston (CHS)

Avianca • Non-stop • Coach
Price was $1,008, price is now $849 per person
$849
per person
found 1 day ago
Great atmosphere. Staff was very helpful when asking for directions and information, some more than others. Everything was clean. I really liked this hotel and my stay.

Reviewed on Aug 4, 2026

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More About Flying To Panama City from Charleston

Route Information for Flights from Charleston to Panama City

Origin Airport IATA Code
CHS
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Charleston to Panama City

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Frequently asked questions

What is the shortest flight from Charleston to Panama City?
The quickest flight from Charleston, SC (CHS-Charleston Intl.) to Tocumen Intl. Airport (PTY) is 4 hours and 35 minutes. Slip a few things into your carry-on to help pass the time, like an interesting read or a crossword puzzle.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.