$281 Cheap flight deals from Charleston (CHS) to Medellín (MDE)

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Airfares from $281 One Way, $843 Round Trip from Charleston to Medellín

Prices starting at $843 for return flights and $281 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 3 - Mon, Sep 7
CHS
Charleston
MDE
Medellín
$843 Roundtrip, found 1 day ago
$843
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 3 from Charleston to Medellín, returning Mon, Sep 7, priced at $843 found 1 day ago
Thu, Sep 3 - Mon, Sep 7
CHS
Charleston
MDE
Medellín
$857 Roundtrip, found 1 day ago
$857
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 3 from Charleston to Medellín, returning Mon, Sep 7, priced at $857 found 1 day ago
Thu, Sep 3 - Mon, Sep 7
CHS
Charleston
MDE
Medellín
$860 Roundtrip, found 1 day ago
$860
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 3 from Charleston to Medellín, returning Mon, Sep 7, priced at $860 found 1 day ago
Thu, Sep 3 - Mon, Sep 7
CHS
Charleston
MDE
Medellín
$865 Roundtrip, found 1 day ago
$865
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 3 from Charleston to Medellín, returning Mon, Sep 7, priced at $865 found 1 day ago
Thu, Sep 3 - Mon, Sep 7
CHS
Charleston
MDE
Medellín
$884 Roundtrip, found 1 day ago
$884
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 3 from Charleston to Medellín, returning Mon, Sep 7, priced at $884 found 1 day ago

Medellín economy flight packages

Price found within the past 48 hours. Click for updated prices.
Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (1,256 reviews)

Aug 17 - Aug 20

3 night stay

Charleston (CHS) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Price was $1,192, price is now $905 per person
$905
per person
found 12 hours ago
The hotel staff are friendly and provide excellent service. The hotel could improve with their pillow selection and the morning coffee, as it doesn’t match the overall quality of the property after all we are in colombia the coffee capital of the world…. I’ve dined at the rooftop restaurant many times it’s a very over priced restaurant, but it’s disappointing that they charge extra if you ask for a little more chips or a little more sauce without telling you. The female manager has a horrible attitude also seems inattentive to guests, often spending time on her phone or watching TV instead of engaging with customers, never again

Reviewed on Jul 2, 2026

The Charlee Hotel
5.0-star property

The Charlee Hotel

8.8/10 Excellent! (1,000 reviews)

Aug 17 - Aug 20

3 night stay

Charleston (CHS) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Price was $1,321, price is now $989 per person
$989
per person
found 12 hours ago
Increíble! Pasamos felices! Todo el Staff es muy amable y el hotel es Impresionante, el desayuno nos encantó y la habitación fue genial.

Reviewed on Jun 29, 2026

Hotel Du Parc
4.5-star property

Hotel Du Parc

9.6/10 Exceptional! (1,001 reviews)

Aug 17 - Aug 20

3 night stay

Charleston (CHS) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Price was $1,222, price is now $961 per person
$961
per person
found 12 hours ago
Overall I’d say 8/10. The staff were all very kind and professional. From the maintenance man to the front desk. It is a little outdated but it’s clean and comfortable. Housekeeping truly changes your linens every day if you’d like. My only safety concern was that the doors don’t have a padlock or anything else from the inside. Big party area, so can hear music even during the weekdays until 3-4AM, but we were fine and my 2 year old slept through it. The lot across from the hotel is abandoned or under construction, not a good look for the area but always felt safe. Breakfast was good, lots of fruit variety and egg/omelette station. Had dinner once and it took 30 min to get our food, we were the only guests eating, but it was tasty.

Reviewed on Jun 30, 2026

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More About Flying To Medellín from Charleston

Route Information for Flights from Charleston to Medellín

Origin Airport IATA Code
CHS
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Charleston to Medellín

If you are looking to get guaranteed low prices for Charleston to Medellín flights then Orbitz is the place to go. We use cutting edge mobile tools to find the best deals on air tickets and to keep you updated on delays and changes.

Get Package Savings by Booking Flights and Hotels at the Same Time

Using the Orbitz Matrix display, you can see how much you will save on flights from Charleston to Medellín if the discount fare is combined with a hotel. You can also look at hotel reviews, photos and maps of the area, so it will be convenient to make your budget travel plans.

Orbitz for Business Helps Corporations save Money

Orbitz can assist all businesses from the small to major corporations with discounts on flights from Charleston to Medellín. We fine- tune your needs for Charleston to Medellín flights and optimize your plans by assessing your business and coming up with ways for you to save on air tickets.

Using Online Check-In Makes Flying Simple

You can use the Orbitz website to check-in for your flights from Charleston to Medellín. You can also make changes to your schedule or even cancel a flight.

Frequently asked questions

What is the shortest flight from Charleston to Medellin?
With the journey from Charleston, SC (CHS-Charleston Intl.) to Medellin Airport taking a minimum of 4 hours and 50 minutes, you'll have plenty of time to enjoy the flying experience. Order a glass of red and get comfy in your seat with a riveting novel or movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.