$97 Cheap flight deals from St. Louis (STL) to James Island (CHS)

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Airfares from $97 One Way, $194 Round Trip from St. Louis to James Island

Prices starting at $194 for return flights and $97 for one-way flights to James Island were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, May 6 - Fri, May 8
STL
St. Louis
CHS
Charleston
$194 Roundtrip, found 3 days ago
$194
Roundtrip
found 3 days ago
Select United flight, departing Wed, May 6 from St. Louis to Charleston, returning Fri, May 8, priced at $194 found 3 days ago
Tue, May 19 - Sun, May 24
STL
St. Louis
CHS
Charleston
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 19 from St. Louis to Charleston, returning Sun, May 24, priced at $197 found 2 days ago
Mon, Oct 19 - Fri, Oct 23
STL
St. Louis
CHS
Charleston
$197 Roundtrip, found 6 days ago
$197
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Oct 19 from St. Louis to Charleston, returning Fri, Oct 23, priced at $197 found 6 days ago
Wed, May 6 - Fri, May 8
STL
St. Louis
CHS
Charleston
$198 Roundtrip, found 3 days ago
$198
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, May 6 from St. Louis to Charleston, returning Fri, May 8, priced at $198 found 3 days ago
Wed, May 6 - Fri, May 8
STL
St. Louis
CHS
Charleston
$203 Roundtrip, found 3 days ago
$203
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, May 6 from St. Louis to Charleston, returning Fri, May 8, priced at $203 found 3 days ago

James Island economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo Mount Pleasant by IHG
3.5-star property

Hotel Indigo Mount Pleasant by IHG

9/10 Wonderful! (1,000 reviews)

Mar 18 - Mar 24

6 night stay

St. Louis (STL) to Charleston (CHS)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $908, price is now $686 per person
$686
per person
found 1 day ago
The staff was kind and accommodating. I enjoyed the amenities and the convenient location. The food at the bar/restaurant was well cooked and I also enjoyed how clean the hotel was. The pool area is beautiful. Will definitely come back. Susie at the front desk displayed exceptional customer service and hospitality.

Reviewed on Jan 10, 2026

The Ryder Hotel
3.5-star property

The Ryder Hotel

8.6/10 Excellent! (1,002 reviews)

Mar 18 - Mar 24

6 night stay

St. Louis (STL) to Charleston (CHS)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $2,266, price is now $1,517 per person
$1,517
per person
found 1 day ago
Love this hotel for the clean room, really great staff and the bar and pool area.

Reviewed on May 11, 2025

Andrew Pinckney Inn
4.0-star property

Andrew Pinckney Inn

9.6/10 Exceptional! (1,413 reviews)

Apr 2 - Apr 5

3 night stay

St. Louis (STL) to Charleston (CHS)

Delta • Non-stop • Coach

Charleston (CHS) to St. Louis (STL)

American Airlines • Non-stop • Coach
Price was $1,233, price is now $909 per person
$909
per person
found 1 day ago
The staff were pleasant and helpful. The location was fantastic for parking, walking and enjoying the City. The rooms were clean and nice. The happy hour wine and cheese were the icing on the cake!! You will love it.

Reviewed on Jan 30, 2026

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More About Flying To James Island from St. Louis

Route Information for Flights from St. Louis to James Island

Origin Airport IATA Code
STL
Destination Airport IATA Code
CHS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to James Island

If you are looking to get guaranteed low prices for St. Louis to James Island flights then Orbitz is the place to go. We use cutting edge mobile tools to find the best deals on air tickets and to keep you updated on delays and changes.

Get Package Savings by Booking Flights and Hotels at the Same Time

Using the Orbitz Matrix display, you can see how much you will save on flights from St. Louis to James Island if the discount fare is combined with a hotel. You can also look at hotel reviews, photos and maps of the area, so it will be convenient to make your budget travel plans.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.