Business Hotels in Florence, SC
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Florence Business Hotels

Baymont Inn & Suites Florence by Wyndham
1826 W Lucas Street, Florence, SC
Guests of Baymont Inn & Suites Florence by Wyndham enjoy a gym, free WiFi in public areas, and meeting rooms. If you drive, take advantage of free parking. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$103 nightly
The price is $116 total per night
$116 total
Aug 11 - Aug 12
Total includes taxes and fees
Guests staying at TownePlace Suites by Marriott Florence enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.

Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $123 total per night
$123 total
Sep 7 - Sep 8
Total includes taxes and fees
At Home2 Suites by Hilton Florence, SC, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. Front-desk staff can answer questions 24/7, and assist with tours or tickets, securing valuables, and dry cleaning/laundry. Additional amenities include a business center, an arcade/game room, and laundry facilities.

Best Western Inn
1808 W Lucas Street, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $111 total per night
$111 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests of Best Western Inn enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is included with your stay. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include express check-out and a vending machine.

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$61 nightly
The price is $69 total per night
$69 total
Sep 3 - Sep 4
Total includes taxes and fees
Days Inn by Wyndham Florence Near Civic Center features free WiFi in public areas, meeting rooms, and a business center. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a seasonal outdoor pool, laundry facilities, and a vending machine.

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$85 nightly
The price is $95 total per night
$95 total
Sep 6 - Sep 7
Total includes taxes and fees
Guests of Quality Inn & Suites Florence Civic Center enjoy a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.

Fairfield Inn by Marriott Hartsville
200 S 4th St, Hartsville, SC
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $105 total per night
$105 total
Aug 17 - Aug 18
Total includes taxes and fees
At Fairfield Inn by Marriott Hartsville, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include a business center, coffee/tea in a common area, and express check-in.

Sleep Inn Florence North
1833 Florence Park Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$72 nightly
The price is $81 total per night
$81 total
Aug 24 - Aug 25
Total includes taxes and fees
Sleep Inn Florence North features a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$138 nightly
The price is $155 total per night
$155 total
Aug 21 - Aug 22
Total includes taxes and fees
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$104 nightly
The price is $116 total per night
$116 total
Sep 2 - Sep 3
Total includes taxes and fees
Guests of Spark by Hilton Florence North I-95, SC have access to an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, a meeting room, and a computer station.

The Inn at the Crossroads
128 West Main Street, Lake City, SC
Free Cancellation
Reserve now, pay when you stay
$149 nightly
The price is $167 total per night
$167 total
Aug 10 - Aug 11
Total includes taxes and fees
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr, Florence, SC
Free Cancellation
$122 nightly
The price is $137 total per night
$137 total
Aug 14 - Aug 15
Total includes taxes and fees
Guests of Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff standing by 24 hours a day to assist with dry cleaning/laundry and securing valuables. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.

Best Western Executive Inn
1534 Highway 38 W, Latta, SC
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $116 total per night
$116 total
Aug 17 - Aug 18
Total includes taxes and fees
Guests of Best Western Executive Inn have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a business center and a vending machine.

Clarion Inn & Suites
1819 West Lucas Street, Building A, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$54 nightly
The price is $60 total per night
$60 total
Aug 22 - Aug 23
Total includes taxes and fees
At Clarion Inn & Suites, guests have access to a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The 24-hour front desk has multilingual staff ready to help with dry cleaning or laundry, and answer any questions about the area. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.

Super 8 by Wyndham Florence
1832 1/2 Lucas Street, I95 Exit 164, Florence, SC
Free Cancellation
Reserve now, pay when you stay
$55 nightly
The price is $62 total per night
$62 total
Aug 17 - Aug 18
Total includes taxes and fees
Super 8 by Wyndham Florence features free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. This motel also has a computer station.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florence hotels essential information
Accommodation | 340 hotels |
---|---|
Lowest Price | $60 |
Highest Price | $167 |
Popular hotels | Baymont Inn & Suites Florence by Wyndham, TownePlace Suites by Marriott Florence, Home2 Suites by Hilton Florence, SC, Best Western Inn, Days Inn by Wyndham Florence Near Civic Center, Quality Inn & Suites Florence Civic Center, Fairfield Inn by Marriott Hartsville, Sleep Inn Florence North, Hotel Florence, Tapestry Collection by Hilton, Spark by Hilton Florence North I-95, SC, The Inn at the Crossroads, Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG, Best Western Executive Inn, Clarion Inn & Suites, Super 8 by Wyndham Florence |
Recent Business Hotels Reviews

Comfort Inn & Suites
5/5 Excellent
"I’ve stated this property two or three times on my travels to Florida and back. My room was quiet, comfortable, and bad comfortable Breakfast was good. "
A verified traveler stayed at Comfort Inn & Suites
Posted 1 day ago
Other Business Hotels
Areas Of Florence
Hotels Near
Hotel Themes
Top Trending
Hotels
- Beach Resorts & Hotels in Charleston
- Hotels in Hilton Head Island
- Oceanfront Hotels in Myrtle Beach
- Hotels with Hot Tubs in Charleston
- Hotels in Mount Pleasant
- Cheap Hotels in Columbia
- Beach Resorts & Hotels in Myrtle Beach
- All Inclusive Resorts & Hotels in Myrtle Beach
- Cheap Hotels in Charleston
- Hotels with Hot Tubs in Greenville
- Hotels in Myrtle Beach
- Hotels in Folly Beach
- All Inclusive Resorts & Hotels in Charleston
- Hotels with Hot Tubs in Myrtle Beach
- Cheap Hotels in Myrtle Beach
- All Inclusive Resorts & Hotels in Hilton Head Island
- Oceanfront Hotels in North Myrtle Beach
- Hotels in Charleston
- Beach Resorts & Hotels in Hilton Head Island
- Hotels with Hot Tubs in Columbia
- Hotels in Columbia
Flights