Book 5 Star Hotels in St. Charles
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured St. Charles 5 Stars Hotels
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.54 mi from city center
$183 nightly
The price is $214 total per night
$214 total
Dec 29 - Dec 30
Total with taxes and fees
Guests of Ameristar Casino Resort and Spa have access to a full-service spa, a casino, and a 24-hour gym. The 24-hour front desk has multilingual staff ready to assist with luggage storage and concierge services. Other amenities at this luxury hotel include 2 hot tubs, a conference center, and a seasonal outdoor pool.
Pool
Hot Tub
Best Western Plus The Charles Hotel
1425 South 5th Street St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.22 mi from city center
$88 nightly
The price is $102 total per night
$102 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
At Best Western Plus The Charles Hotel, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Breakfast included
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
Free Cancellation
Reserve now, pay when you stay
3.33 mi from city center
$89 nightly
The price is $103 total per night
$103 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Hampton Inn St. Charles St. Peters, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this golf hotel include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub
Country Inn & Suites by Radisson, St. Charles Historic District
1190 S Main St St. Charles MO
Free Cancellation
1.27 mi from city center
$112 nightly
The price is $129 total per night
$129 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
Guests staying at Country Inn & Suites by Radisson, St. Charles Historic District enjoy an indoor pool, a gym, and free WiFi in public areas. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with concierge services, luggage storage, and securing valuables. Additional amenities include a library, laundry facilities, and a fireplace in the lobby.
Pool
Breakfast included
Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.29 mi from city center
$122 nightly
The price is $140 total per night
$140 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Embassy Suites by Hilton St. Louis St. Charles enjoy an indoor pool, a gym, and WiFi in public areas. If you drive, put free parking to good use. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include meeting rooms, express check-in, and express check-out.
Pool
Breakfast included
Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.55 mi from city center
$115 nightly
The price is $133 total per night
$133 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Drury Plaza Hotel St. Louis St. Charles features an indoor pool, an outdoor pool, and a 24-hour gym. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with dry cleaning or laundry, and answer any questions about the accommodations. Additional amenities include free WiFi in public areas, a hot tub, and meeting rooms.
Pool
Hot Tub
Comfort Suites St Charles - St Louis
1400 S 5th St St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.34 mi from city center
$79 nightly
The price is $90 total per night
$90 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Comfort Suites St Charles - St Louis enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a computer station.
Pool
Breakfast included
Hampton Inn & Suites St. Charles Old Town Area
1410 SOUTH 5TH STREET St. Charles MO
Free Cancellation
Reserve now, pay when you stay
1.42 mi from city center
$108 nightly
The price is $131 total per night
$131 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
Guests of Hampton Inn & Suites St. Charles Old Town Area have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and luggage storage. Additional amenities include a 24-hour business center and laundry facilities.
Pool
Breakfast included
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Free Cancellation
Reserve now, pay when you stay
20.09 mi from city center
$99 nightly
The price is $117 total per night
$117 total
Dec 30 - Dec 31
Total with taxes and fees
Guests staying at Hyatt Regency St. Louis at The Arch enjoy a gym, a rooftop terrace, and free WiFi in public areas. Parking is available for USD 40 per night (USD 50 per day for valet parking), and there's also limo/town car service. The 24-hour front desk has multilingual staff ready to assist with luggage storage, concierge services, and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pet friendly
Free WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best 5 star hotels in St. Charles
Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in St. Charles. After all, treating yourself to the finer things is what vacations are about.
What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These St. Charles hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.
What amenities can I expect at a 5 star hotel?
St. Charles 5 star hotels and resorts typically offer luxury amenities such as:
- Gourmet restaurant
- Full-service fitness center with pool
- Luxury spa
- Welcome gifts upon arrival
- Top-of-the-line beds and linens
- Designer personal care products
- Premium cable, free Wi-Fi and device docking stations
How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in St. Charles with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place:
- Search hotels by price, ranging from $90 to $214
- Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
- Choose from 2,281 5 star hotels in St. Charles!
St. Charles hotels essential information
Accommodation | 2,281 hotels |
|---|---|
Lowest Price | $90 |
Highest Price | $214 |
Popular hotels | Ameristar Casino Resort and Spa, Best Western Plus The Charles Hotel, Hampton Inn St. Charles St. Peters, Country Inn & Suites by Radisson, St. Charles Historic District, Embassy Suites by Hilton St. Louis St. Charles, Drury Plaza Hotel St. Louis St. Charles, Comfort Suites St Charles - St Louis, Hampton Inn & Suites St. Charles Old Town Area, Hyatt Regency St. Louis at The Arch |
Recent Reviews
Hampton Inn St. Charles St. Peters
5/5 Excellent
"very friendly staff and good location
"
A verified traveler stayed at Hampton Inn St. Charles St. Peters
Posted 1 day ago
More to Explore
- Hotels in St. Charles Historic District
- Hotels near Ameristar Casino St. Charles
- Hotels near Family Arena
- Visit Kokomo Joe's Family Fun Center
- Hotels in Earth City
- Hotels near Hollywood Casino
- Hotels in Bridgeton
- Hotels near Lindenwood University
- Hotels near St Charles Convention Center
- Hotels near Hollywood Casino Amphitheatre