Hotels near Main Street Hyannis

Search over 3,596 hotels from $80

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Apr 27 - Apr 28
Tonight
Check prices close to Main Street Hyannis for tonight, Apr 27 - Apr 28
Apr 28 - Apr 29
Tomorrow night
Check prices close to Main Street Hyannis for tomorrow night, Apr 28 - Apr 29

Featured Hotels near Main Street Hyannis

Hyannis Travel Inn

Hyannis Travel Inn

2.5 out of 5
18 North St Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.15 mi from Main Street Hyannis
$82 nightly
The price is $94 total per night
$94 total
May 5 - May 6
Total with taxes and fees
At Hyannis Travel Inn, guests enjoy an indoor pool, an outdoor pool, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can help with tours or tickets, and provide local restaurant recommendations. Additional amenities include a hot tub, coffee/tea in a common area, and express check-out.
Pool
Hot Tub
Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel

2.5 out of 5
540 Old Colony Rd Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.17 mi from Main Street Hyannis
$114 nightly
The price is $130 total per night
$130 total
May 28 - May 29
Total with taxes and fees
Guests staying at Heritage House Inn on Cape Cod, an Ascend Collection Hotel enjoy features like an indoor pool. You can take advantage of free parking if you drive. Helpful staff is there to provide front-desk service during limited hours, as well as offer insight about the area.
Pool
Breakfast included
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

2.5 out of 5
259 Main Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.18 mi from Main Street Hyannis
$104 nightly
The price is $120 total per night
$120 total
Apr 29 - Apr 30
Total with taxes and fees
Comfort Inn Hyannis - Cape Cod offers an indoor pool, free WiFi in public areas, and a hot tub. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to help with luggage storage, and answer any questions about the area. Additional amenities include a business center, a terrace, and wedding services.
Pool
Hot Tub
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.39 mi from Main Street Hyannis
$149 nightly
The price is $171 total per night
$171 total
May 5 - May 6
Total with taxes and fees
Guests of Hyannis Harbor Hotel have access to an indoor pool, a children's pool, and free WiFi in public areas. If you decide to drive, there's free parking. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

3 out of 5
1 South Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.4 mi from Main Street Hyannis
$152 nightly
The price is $174 total per night
$174 total
Apr 28 - Apr 29
Total with taxes and fees
Guests of Anchor In Distinctive Waterfront Lodging enjoy access to free WiFi in public areas, a seasonal outdoor pool, and coffee in a common area. Self parking is offered for USD 10.00 per night. Front-desk staff can assist with luggage storage, tours or tickets, and securing valuables. Additional amenities include a microwave in a common area, free use of bicycles, and a computer station.
Pool
Breakfast included
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.54 mi from Main Street Hyannis
$96 nightly
The price is $110 total per night
$110 total
May 3 - May 4
Total with taxes and fees
Hyannis Plaza Hotel offers an outdoor pool, a seasonal outdoor pool, and coffee in a common area. Free parking is included with your stay. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Other amenities at this luxury hotel include a microwave in a common area, a garden, and a vending machine.
Pool
Parking included
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28 West Yarmouth MA
Free Cancellation
Reserve now, pay when you stay
1.21 mi from Main Street Hyannis
$70 nightly
The price is $80 total per night
$80 total
Apr 28 - Apr 29
Total with taxes and fees
Guests staying at Cape Sands Inn enjoy an indoor pool, a sauna, and free WiFi in public areas. You can take advantage of free parking if you drive. Staff members can answer questions about accommodations, and also provide front-desk service during limited hours. Other amenities at this family-friendly motel include a hot tub, a business center, and a seasonal outdoor pool.
Pool
Hot Tub
Bayside Resort Hotel

Bayside Resort Hotel

3 out of 5
225 Route 28 West Yarmouth MA
Free Cancellation
Reserve now, pay when you stay
1.41 mi from Main Street Hyannis
$121 nightly
The price is $138 total per night
$138 total
Apr 28 - Apr 29
Total with taxes and fees
At Bayside Resort Hotel, guests enjoy an indoor pool, a gym, and a sauna. Free parking is available if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Other amenities at this beach hotel include free WiFi in public areas, a hot tub, and conference space.
Pool
Hot Tub
Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

4 out of 5
1225 Iyannough Rd Hyannis MA
Free Cancellation
Reserve now, pay when you stay
2.02 mi from Main Street Hyannis
$177 nightly
The price is $202 total per night
$202 total
May 3 - May 4
Total with taxes and fees
Guests of Margaritaville Resort Cape Cod have access to a full-service spa, a water park, and an outdoor pool. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with concierge services, access to locker space, and securing valuables. Other amenities at this spa resort include a lazy river, a children's pool, and a gym.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Main Street Hyannis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Main Street Hyannis hotels essential information

Accommodation
3,596 hotels
Lowest Price
$80
Highest Price
$202
Popular hotels
Hyannis Travel Inn, Margaritaville Resort Cape Cod, Bayside Resort Hotel, Comfort Inn Hyannis - Cape Cod, Anchor In Distinctive Waterfront Lodging, Hyannis Harbor Hotel, Hyannis Plaza Hotel, Cape Sands Inn, Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Recent Reviews

Bayside Resort Hotel

Bayside Resort Hotel

4/5 Good
"We enjoyed our stay at the resort. The indoor pool and hot tub were perfect. We enjoyed the fire by the bay. The walls are thin and we ended up using a white noise ap to block out the noise. A warning to anyone who struggles with stairs. There is not an elevator and even if you get a first floor room the breakfast buffet is gonna flight of stairs. If stairs aren’t an issue for your group then this is a great hotel."
A verified traveler stayed at Bayside Resort Hotel
Posted 13 hours ago
Bayside Resort Hotel

More to Explore