Cheap flights from RSW to FLO (Southwest Florida Intl. to Florence Regional)
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Cheap Flights from RSW to FLO starting at $284 One Way, Round Trip
Prices starting at for return flights and $284 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Hotel Ideas near Florence Regional
Airport Hotels near Florence Regional
Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Feb 2 to Feb 3
$112 total
Feb 2 - Feb 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,000 reviews)
No dinner options
Reviewed on Jan 13, 2026
Hotel Florence, Tapestry Collection by Hilton
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Jan 25 to Jan 26
$146 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (613 reviews)
Didn't stay long enough to try any of the amenities that they offer.
Reviewed on Jan 11, 2026
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees
Florence SC
Stay at this vacation home in Florence. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Old Greenwood Athletic Park and Greenwood Baseball ...
9.6/10 Exceptional! (6 reviews)
The house was nice and had everything we needed. Everything was clean.
Reviewed on Sep 1, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels In Florence
Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
$70 nightly
The price is $79 total per night from Jan 16 to Jan 17
$79 total
Jan 16 - Jan 17
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,530 reviews)
Great price, beds were comfortable though pillows were a little weak. Clean and quiet. Slightly substandard continental breakfast that we just avoided but still a great value stay.
Reviewed on Jan 13, 2026
Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Jan 18 to Jan 19
$95 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,235 reviews)
Stay was nice had no issues. Very quiet. Great breakfast choices
Reviewed on Jan 13, 2026
Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
$96 nightly
The price is $108 total per night from Feb 15 to Feb 16
$108 total
Feb 15 - Feb 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,187 reviews)
Nice staff, clean, , convenient location
Reviewed on Jan 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Low Priced Florence Hotels
Red Roof Inn Florence - Civic Center
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Jan 19 to Jan 20
$63 total
Jan 19 - Jan 20
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,000 reviews)
Room was good. No microwave tho. Staff was very courteous and helpful
Reviewed on Jan 9, 2026
Budget Inn Timmonsville
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Jan 18 to Jan 19
$68 total
Jan 18 - Jan 19
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (324 reviews)
Clean room, great for price, stayed with spouse, 2 children and two pets. You can hear cars pulling in and out of this location. There was a homeless guy asking for money but you can encounter that anywhere. No bugs, no concerns. :)
Reviewed on Dec 29, 2025
Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
$59 nightly
The price is $66 total per night from Jan 22 to Jan 23
$66 total
Jan 22 - Jan 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,000 reviews)
Receptionist was very professional and polite. And took her time to answer every question.
Reviewed on Jan 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Florence
Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd Florence SC
$106 nightly
The price is $119 total per night from Feb 8 to Feb 9
$119 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,005 reviews)
The service at this location is always great, I stay at this location every time that I’m in town.
Reviewed on Jan 12, 2026
Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
$98 nightly
The price is $110 total per night from Jan 26 to Jan 27
$110 total
Jan 26 - Jan 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (37 reviews)
Estuvimos en Spark by Hilton Florence North I-95 de paso y fue una experiencia aceptable. La ubicación es muy conveniente justo saliendo de la I-95, el desayuno continental estaba incluido y la habitación era cómoda. Aceptan mascotas con cargo adicional, lo cual fue perfecto para nuestro perrito ...
Reviewed on Jan 4, 2026
Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
$59 nightly
The price is $66 total per night from Jan 22 to Jan 23
$66 total
Jan 22 - Jan 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,000 reviews)
Receptionist was very professional and polite. And took her time to answer every question.
Reviewed on Jan 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
RSW to FLO Route Info
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RSW Address & GPS
Address:
11000 Terminal Access Road
Fort Myers FL,
United States
IATA Code:
RSW
Longitude:
-81.755263
Latitude:
26.527887
Time Zone:
America/New_York
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York
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Frequently asked questions
Map To Nearby Hotels
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.