$321 Cheap flight deals from Sioux Falls (FSD) to Ocean Isle Beach (MYR)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Airfares from $321 One Way, $527 Round Trip from Sioux Falls to Ocean Isle Beach

Prices starting at $527 for return flights and $321 for one-way flights to Ocean Isle Beach were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Sep 7 - Thu, Sep 10
FSD
Sioux Falls
MYR
Myrtle Beach
$527 Roundtrip, found 5 hours ago
$527
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Mon, Sep 7 from Sioux Falls to Myrtle Beach, returning Thu, Sep 10, priced at $527 found 5 hours ago
Mon, Sep 7 - Thu, Sep 10
FSD
Sioux Falls
MYR
Myrtle Beach
$559 Roundtrip, found 5 hours ago
$559
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Mon, Sep 7 from Sioux Falls to Myrtle Beach, returning Thu, Sep 10, priced at $559 found 5 hours ago
Mon, Sep 7 - Thu, Sep 10
FSD
Sioux Falls
MYR
Myrtle Beach
$569 Roundtrip, found 5 hours ago
$569
Roundtrip
found 5 hours ago
Select Delta flight, departing Mon, Sep 7 from Sioux Falls to Myrtle Beach, returning Thu, Sep 10, priced at $569 found 5 hours ago
Fri, Sep 18 - Sat, Sep 26
FSD
Sioux Falls
MYR
Myrtle Beach
$576 Roundtrip, found 11 hours ago
$576
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Sep 18 from Sioux Falls to Myrtle Beach, returning Sat, Sep 26, priced at $576 found 11 hours ago
Mon, Sep 7 - Thu, Sep 10
FSD
Sioux Falls
MYR
Myrtle Beach
$582 Roundtrip, found 5 hours ago
$582
Roundtrip
found 5 hours ago
Select United flight, departing Mon, Sep 7 from Sioux Falls to Myrtle Beach, returning Thu, Sep 10, priced at $582 found 5 hours ago

Ocean Isle Beach economy flight packages

Price found within the past 48 hours. Click for updated prices.
Westgate Myrtle Beach Oceanfront Resort
3.5-star property

Westgate Myrtle Beach Oceanfront Resort

8.6/10 Excellent! (1,258 reviews)

Sep 18 - Sep 26

8 night stay

Sioux Falls (FSD) to Myrtle Beach (MYR)

American Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $1,772, price is now $957 per person
$957
per person
found 11 hours ago
The staff was very friendly and We brought our 2 little kids under 5 years old, and we had all the amenities that we need, the only thing that people should know that there is no breakfast. That is free and they only serve breakfast on Saturday and Sunday and that is for a fee. The poor it was very nice. The lazy river was nice. And the kids mini water park was nice. The hotel is a 2 minute drive, 12 minute walk hotel room was clean. The water pressure was okay could have been better. But overall, I would rate this a eight out of a ten

Reviewed on Jul 28, 2026

Marina Inn At Grande Dunes
4.5-star property

Marina Inn At Grande Dunes

9.4/10 Exceptional! (1,778 reviews)

Sep 18 - Sep 26

8 night stay

Sioux Falls (FSD) to Myrtle Beach (MYR)

American Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $2,537, price is now $1,937 per person
$1,937
per person
found 11 hours ago

North Beach Resort & Villas
4.0-star property

North Beach Resort & Villas

8.8/10 Excellent! (1,019 reviews)

Sep 18 - Sep 26

8 night stay

Sioux Falls (FSD) to Myrtle Beach (MYR)

American Airlines • Roundtrip • Coach
Price was $2,252, price is now $1,785 per person
$1,785
per person
found 11 hours ago
I really enjoyed this property. Now my room did have a lot of toilet issues. But the resort was very accommodating in this situation. I would definitely stay here again.

Reviewed on Jul 29, 2026

Don't see what you're looking for?
See all available trips from Sioux Falls to Ocean Isle Beach
View all trips

More About Flying To Ocean Isle Beach from Sioux Falls

Route Information for Flights from Sioux Falls to Ocean Isle Beach

Origin Airport IATA Code
FSD
Destination Airport IATA Code
MYR
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Sioux Falls to Ocean Isle Beach

Orbitz gives you great deals on your flights from Sioux Falls to Ocean Isle Beach. If you also need a discount car rental or a cheap hotel room after you arrived at your destination, Orbitz has you covered.

We Offer Great Travel Deals and Discounts

When you book flights from Sioux Falls to Ocean Isle Beach with Orbitz for, you can be assured that you are getting the lowest price possible. Orbitz works constantly with our airline partners to ensure guaranteed low prices on Sioux Falls to Ocean Isle Beach flights for your trip—whether you are traveling for business or for fun with your family.

Enjoy Savings on Last-Minute Flights

If you are looking for a discount price on last-minute flights from Sioux Falls to Ocean Isle Beach, chances are that Orbitz can offer you a deal that will save you lots of money. Whether you just want to get away for the weekend or go on a vacation lasting weeks, Orbitz can help you find the best deals on Sioux Falls to Ocean Isle Beach flights that fit your budget and your itinerary for the perfect trip.

Full-Service Mobile Apps

Need more mobility when it comes to travel planning? Orbitz has easy-to-use mobile apps for iPhone, iPad, and Android, to help the traveler on the go. Not only can use the apps to find huge savings on Sioux Falls to Ocean Isle Beach flights wherever you are, but you can also check out and book discount hotel rooms too. The apps will also keep you up-to-date when it’s time to fly. Get easy access to your itinerary for flights from Sioux Falls to Ocean Isle Beach and review gate and baggage claim details too.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.